Abstract
In rodents olfactory stimuli are essential for socio-sexual behaviour. Volatile stimuli mainly activate the main olfactory system, whereas non-volatile ones, some of them considered as pheromones, activate the accessory olfactory system. Traditionally, it has been considered that the efferent projections of the main and the accessory olfactory bulbs innervate different telencephalic areas. Recent studies performed in rats and mice have challenged this view. In this work we explore in mice, through the use of anterograde tracer injections in the olfactory bulbs, the brain centres where olfactory and vomeronasal information might converge.
Our results show that the olfactory and vomeronasal projections overlap mainly in the cortex-amygdaloid transition area, the anterior cortical amygdala and the medial amygdala (anterior and posterodorsal divisions), as well as, to a minor extent, in the anterior amygdaloid area and a restricted zone of the anterior piriform cortex. This indicates the existence of amygdaloid areas where the association between the olfactory and vomeronasal stimuli coming from the main and accessory olfactory bulb can take place. The chemosensory associative areas described in the amygdala might play a role in emotional learning involving the association of odours and pheromones.
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References
Brennan PA, Kendrick KM (2006) Mammalian social odours: attraction and individual recognition. Philos Trans R Soc Lond B Biol Sci 361:2061–2078
Dibenedictis BT, Ingraham KL, Baum MJ, Cherry JA (2012) Disruption of urinary odor preference and lordosis behavior in female mice given lesions of the medial amygdala. Physiol Behav 105:554–559
Gutiérrez-Castellanos N, Martínez-Marcos A, Martínez-García F, Lanuza E (2010) Chemosensory functions of the amygdala. Vitam Horm 83:165–193
Halpern M (1987) The organization and function of the vomeronasal system. Annu Rev Neurosci 10:325–362
Kang N, Baum KJ, Cherry JA (2009) A direct main olfactory bulb projection to the “vomeronasal” amygdala in female mice selectively responds to volatile pheromones from males. Eur J Neurosci 29:624–634
Kang N, Baum KJ, Cherry JA (2011a) Different profiles of main and accessory olfactory bulb mitral/tufted cell projections revealed in mice using an anterograde tracer and a whole-mount, flattened cortex preparation. Chem Senses 36:251–260
Kang N, McCarthy EA, Cherry JA, Baum KJ (2011b) A sex comparison of the anatomy and function of the main olfactory bulb–medial amygdala projection in mice. Neuroscience 172:196–204
Keller M, Baum MJ, Brock O, Brennan PA, Bakker J (2009) The main and accessory olfactory systems interact in the control of mate recognition and sexual behavior. Behav Brain Res 200:268–276
Krieger J, Schmitt A, Löbel D, Gudermann T, Schultz G, Breer H, Boekhoff I (1999) Selective activation of G protein subtypes in the vomeronasal organ upon stimulation with urine-derived compounds. J Biol Chem 274:4655–4662
Maras PM, Petrulis A (2006) Chemosensory and steroid-responsive regions of the medial amygdala regulate distinct aspects of opposite-sex odor preference in male Syrian hamsters. Eur J Neurosci 24:3541–3552
Martínez-García F, Martinez-Ricós J, Agustín-Pavón C, Martínez-Hernández J, Novejarque A, Lanuza E (2009) Refining the dual olfactory hypothesis: pheromone reward and odour experience. Behav Brain Res 200:277–286
Martínez-García F, Novejarque A, Gutiérrez-Castellanos N, Lanuza E (2012) Piriform cortex and amygdala. In: Watson C, Paxinos G, Puelles L (eds) The mouse nervous system. Academic, Amsterdam, pp 140–220
Martínez-Ricós J, Agustín-Pavón C, Lanuza E, Martínez-García F (2008) Role of vomeronasal system in intersexual attraction in female mice. Neuroscience 153:383–395
Mohedano-Moriano A, Pro-Sistiaga P, Ubeda-Bañon I, Crespo C, Insausti R, Martinez-Marcos A (2007) Segregated pathways to the vomeronasal amygdala: differential projections from the anterior and posterior divisions of the accessory olfactory bulb. Eur J Neurosci 25:2065–2080
Moncho-Bogani J, Lanuza E, Hernández A, Novejarque A, Martínez-García F (2002) Attractive properties of sexual pheromones in mice: innate or learned? Physiol Behav 77:167–176
Moncho-Bogani J, Martínez-García F, Novejarque A, Lanuza E (2005) Attraction to sexual pheromones and associated odorants in female mice involves activation of the reward system and basolateral amygdala. Eur J Neurosci 21:2186–2198
Papes F, Logan DW, Stowers L (2010) The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs. Cell 141:692–703
Pro-Sistiaga P, Mohedano-Moriano A, Ubeda-Bañon I, Arroyo-Jimenez M, Marcos P, Artacho-Pérula E, Crespo C, Insausti R, Martinez-Marcos A (2007) Convergence of olfactory and vomeronasal projections in the rat basal telencephalon. J Comp Neurol 504:346–362
Roberts SA, Simpson DM, Armstrong SD, Davidson AJ, Robertson DH, McLean L, Beynon RJ, Hurst JL (2010) Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male’s odour. BMC Biol 8:75
Scalia F, Winans SS (1975) The differential projections of the olfactory bulb and accessory olfactory bulb in mammals. J Comp Neurol 161:31–56
Shipley MT, Adamek GD (1984) The connections of the mouse olfactory bulb: a study using orthograde and restrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase. Brain Res Bull 12:669–688
Skeen LC, Hall WC (1977) Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis). J Comp Neurol 172:1–36
Von Campenhausen H, Mori K (2000) Convergence of segregated pheromonal pathways from the accessory olfactory bulb to the cortex in the mouse. Eur J Neurosci 12:33–46
Acknowledgments
Funded by the Spanish Ministry of Science-FEDER (BFU2010-16656) and the Junta de Comunidades de Castilla-La Mancha (PEIC11-0045-4490). B.C.-M. is a predoctoral fellow of the “Becas Chile” program of the Government of Chile, and the present work is part of her doctoral thesis.
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Cádiz-Moretti, B., Martínez-García, F., Lanuza, E. (2013). Neural Substrate to Associate Odorants and Pheromones: Convergence of Projections from the Main and Accessory Olfactory Bulbs in Mice. In: East, M., Dehnhard, M. (eds) Chemical Signals in Vertebrates 12. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5927-9_1
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