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Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues

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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 777))

Abstract

A pentaspan membrane glycoprotein prominin-1 (frequently called CD133 in human) is widely used as a surface marker to identify and isolate normal stem/progenitor cells from various organs, although it is also expressed in some types of differentiated cells. Since CD133 was identified as a universal marker to isolate cancer stem cells (CSCs) in tumors derived from multiple tissues, much attention has been directed toward the relationship between its gene regulation and identity of CSCs (i.e., cancer stemness). Prominin-1 (PROM1) gene possesses five alternative promoters yielding multiple first exons within the 5′-untranslated region (UTR) and also splicing variants affecting the open reading frame (ORF) sequence, implicating the complicated gene regulation in a context-dependent manner. This chapter aims to organize the accumulated findings on prominin-1 with a focus on its altered expression and regulation in normal and cancerous cells and to discuss potential regulatory networks underlying cancer stemness.

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Authors and Affiliations

  1. Department of Stem cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, 113-8510, Tokyo, Japan

    Kouichi Tabu Ph.D., Norihisa Bizen & Tetsuya Taga

  2. Department of Pathology, Laboratory of Cancer Research, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, 060-8638, Sapporo, Japan

    Shinya Tanaka

Authors
  1. Kouichi Tabu Ph.D.
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  2. Norihisa Bizen
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  3. Tetsuya Taga
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  4. Shinya Tanaka
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Correspondence to Kouichi Tabu Ph.D. .

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  1. , Biotechnological Centre (BIOTEC), Dresden University of Technology, Fetscherstr. 74, Dresden, 01307, Sachsen, Germany

    Denis Corbeil

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Tabu, K., Bizen, N., Taga, T., Tanaka, S. (2013). Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues. In: Corbeil, D. (eds) Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Advances in Experimental Medicine and Biology, vol 777. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5894-4_5

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