The Environmental and Human Effects of Ptaquiloside-Induced Enzootic Bovine Hematuria: A Tumorous Disease of Cattle

  • Rinku SharmaEmail author
  • Tej K. Bhat
  • Om P. Sharma
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 224)


Enzootic bovine hematuria (EBH) is a disease of cattle that is characterized by the intermittent presence of blood in urine caused by malignant lesions in the urinary bladder. The disease causes anemia, progressive emaciation, and death (Jones and Hunt 1983; Hopkins 1986). This neoplastic disease is primarily caused by chronic ingestion of ferns, and affliction with the papillomavirus is often associated with it (Campo et al. 1992; Campo 1997; Santos et al. 1998). A decade ago, a comprehensive review of this disease was published by Dawra and Sharma (2001). In this review, we provide an update on the various aspects of EBH and include an assessment of the effect of consuming these disease-inducing ferns on both animal and human health, and the associated environmental implications.


Urinary Bladder Bladder Tumor Fern Species Urinary Bladder Cancer Ferritin Heavy Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Disease Investigation LaboratoryIndian Veterinary Research Institute, Regional StationPalampurIndia
  2. 2.Indian Veterinary Research Institute, Regional StationPalampurIndia

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