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Biochemical Basis and Therapeutic Implications of Angiogenesis pp 123–138Cite as

Vascular Stem Cells in Regulation of Angiogenesis

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

Abstract

Angiogenesis is the process by which new vessels are generated from the preexisting blood vessels, which is the major contributor of postnatal neovascularization process. Disruption or dysregulation of angiogenesis is involved in various pathological conditions, such as ischemia and tumor progression. Stimulation of angiogenesis was proposed to be able to restore the blood flow and contribute to the tissue recovery in ischemia, while inhibition of angiogenesis can impede tumor progression. The importance of angiogenesis has generated tremendous interest in studying the mechanisms and to find out major contributors of the process. The current stem cell research has significantly improved our understanding of angiogenesis and its possible therapeutic application. Hypoxia is the most important driving force of angiogenesis, while other factors, such as chemokines and cytokines, haptotaxis, and mechanotaxis, are also important in regulating neovascularization process. In this chapter, we will focus on the progenitor cells that contribute to the angiogenesis and the underlining mechanisms involved in this process.

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Acknowledgements

This work was supported in part by National Institutes of Health grants, K01 AR054114 (NIAMS), SBIR R44 HL092706-01 (NHLBI), R21 CA143787 (NCI), Pelotonia idea award and the Ohio State University start-up fund for stem cell research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Cardiovascular Stem Cell Research Laboratory, The Dorothy M. Davis Heart and Lung Research Institute, Wexner Medical Center at The Ohio State University, 460 West 12th Avenue, BRT 394, Columbus, OH, 43210, USA

    Jingwei Lu, Vincent J. Pompili & Hiranmoy Das

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  1. Jingwei Lu
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  2. Vincent J. Pompili
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  3. Hiranmoy Das
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Correspondence to Hiranmoy Das .

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Editors and Affiliations

  1. Div. of Cardiovascular Medicine, UAMS, Little Rock, AR, USA, 4301 W Markham, Little Rock, 72205, Arkansas, USA

    Jawahar L. Mehta

  2. Institute of Cardiovascular Sciences, St. Boniface Hosp. Research, Univ. of Ma, 351 Tache Avenue, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Lu, J., Pompili, V.J., Das, H. (2013). Vascular Stem Cells in Regulation of Angiogenesis. In: Mehta, J., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5857-9_8

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