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Autologous Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphomas

  • Natthapol Songdej
  • Eric S. Winer
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Non-Hodgkin Lymphoma is a heterogeneous group of lymphoid ­malignancies that involves mature B-cells, mature T-cells, and their progenitors. Although novel chemotherapy and immunotherapy regimens have improved rates of complete response and overall survival, autologous stem cell transplant (ASCT) is used in both the front-line and relapsed setting to further improve these markers and ­potentially cure. Even in indolent lymphomas, ASCT shows a definite ­improvement in ­progression-free survival, although no improvement in overall ­survival. The most promising results for front-line ASCT are in mantle cell lymphoma (MCL), where there is evidence of long-term progression-free and overall survival with evidence of a cured fraction. In the relapsed setting, ASCT is the standard of care in diffuse large B-cell lymphoma, though results of ASCT in the relapsed setting for MCL and Burkitt lymphoma are disappointing. The role and timing of ASCT in peripheral T-cell lymphomas are yet to be defined, but front-line ASCT in ­enteropathy-associated T-cell lymphoma and advanced-stage cutaneous T-cell lymphoma shows promise for improving long-term outcomes. Additional studies on front-line and relapsed ASCT with novel chemotherapy and immunotherapy regimens may demonstrate further improved responses and survival, especially for high-risk patients.

Keywords

Follicular Lymphoma Mantle Cell Lymphoma Autologous Stem Cell Transplant Conditioning Regimen Burkitt Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of MedicineRhode Island Hospital, The Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Division of Hematology and OncologyRhode Island Hospital, The Warren Alpert Medical School of Brown UniversityProvidenceUSA
  3. 3.Comprehensive Cancer Center, University MedicineProvidenceUSA

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