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Nanotoxicology in Green Nanoscience

Chapter

Abstract

Nanotechnology holds great promise for future economical and technological advances, yet health and safety concerns regarding nanomaterials persist. As an emerging technology, nanotechnology is in the unique position to proactively address health and safety concerns throughout the product life cycle. Green chemistry aims to create benign compounds in a way that prevents pollution and reduces waste throughout every stage of production. Through green nanoscience, the principles of green chemistry can be applied toward making high performance, yet inherently safe nanomaterials. Successful application of green chemistry principles to assess nanomaterial health and safety requires efficient, predictive, high-throughput nanotoxicity testing. With these approaches, designers and manufacturers of nanomaterials can assess nanotoxicity early in production to redesign or replace hazardous nanomaterials.

Keywords

Instrumental Neutron Activation Analysis Green Chemistry Zebrafish Embryo Aryl Hydrocarbon Receptor Zinc Finger Nuclease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Glossary

Embryonic development

The molecular signaling, cell divisions, cell rearrangements, and cell differentiation that lead to tissues, organs, and structures of an organism.

High throughput

A method of stream-lining, often through automation, testing procedures to rapidly conduct thousands of experiments.

Nanotechnology

As defined by the National Nanotechnology Initiative, “nanotechnology is the understanding and control of matter at the nanoscale, at dimensions between approximately 1 and 100nm, where unique phenomena enable novel applications.”

Structure activity relationships (SARS)

A method of relating how structural and physiochemical properties of a compound influence biological activity.

Tiered approach

An approach that optimizes identification of potentially hazardous compounds through testing and systematic interpretation of results [1].

Toxicology testing

Testing to examine and understand the adverse effects of physical, biological, or chemical compounds on organisms and the environment with the objective of mitigation or prevention [2].

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Environmental and Molecular Toxicology Environmental Health Sciences CenterOregon State UniversityCorvallisUSA

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