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Characterization of MSCs: From Early Studies to the Present

Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Studies on mesenchymal stem cells/mesenchymal stromal cells (MSCs) have increased dramatically in the last 10 years, and many clinical trials are underway to take advantage of their properties. Early studies on MSC-like cells were performed in laboratories studying either bone repair or hematopoiesis, but the overlap in these studies was not broadly appreciated. The relationship between MSCs, osteoblastic progenitor cells, and the bone marrow stromal cells that provide support for hematopoietic stem cells has emerged. A variety of assays, in vitro and in vivo, allowed for a broader understanding of the MSCs and their characteristics. The MSCs from different animal species have properties similar to those from man, and this has allowed for many animal studies that provided preclinical support for human clinical trials with MSCs. While there are many established characteristics, new understanding of the MSC and the interaction of MSCs with other cell types, including HSCs and those of the immune system, will continue to reveal new and useful understanding of MSC properties.

Keywords

Mesenchymal Stem Cell Osteogenic Differentiation Mesenchymal Stromal Cell Chondrogenic Differentiation Adipogenic Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Surgery/CardiacUniversity of Maryland School of MedicineBaltimoreUSA

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