Abstract
The mesectodermal origin of DPSC makes them a strong source of raw material for various human tissue regenerations in the future. Yamanaka’s group generated iPSCs from DPSC of two putative HLA-homozygous donors who match ∼20 % of the Japanese population at major HLA loci (Okita et al. 2011). The recognition of DPSC–iPSCs infers their availability to begin exploring their therapeutic potential at the preclinical level. However, using them in the area of tooth regeneration and making bio-teeth with all dental, and oro-musculatory and supportive tissue functions seems to be much more complicated. Currently, DPSC-based therapies are offering functional, vascularized, and innervated non-mineralized pulp tissue constructions (Huang et al. 2010; Kim et al. 2010a, b; Iohara et al. 2011; Yang et al. 2012). Furthermore, the stimulation of stem cell niches for odontoblast regeneration warrants further studies. With the help of current emergent concepts of complexity, we can explore the various functions of tooth tissues from a complex adaptive systems perspective.
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Keywords
- Complex Adaptive Systems Perspective
- Human Tissue Regeneration
- Tooth Regeneration
- Iohara
- Stem Cell Niche
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The mesectodermal origin of DPSC makes them a strong source of raw material for various human tissue regenerations in the future. Yamanaka’s group generated iPSCs from DPSC of two putative HLA-homozygous donors who match ∼20 % of the Japanese population at major HLA loci (Okita et al. 2011). The recognition of DPSC–iPSCs infers their availability to begin exploring their therapeutic potential at the preclinical level. However, using them in the area of tooth regeneration and making bio-teeth with all dental, and oro-musculatory and supportive tissue functions seems to be much more complicated. Currently, DPSC-based therapies are offering functional, vascularized, and innervated non-mineralized pulp tissue constructions (Huang et al. 2010; Kim et al. 2010a, b; Iohara et al. 2011; Yang et al. 2012). Furthermore, the stimulation of stem cell niches for odontoblast regeneration warrants further studies. With the help of current emergent concepts of complexity, we can explore the various functions of tooth tissues from a complex adaptive systems perspective.
References
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Kim K et al (2010b) Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res 89(8):842–847
Okita K et al (2011) A more efficient method to generate integration-free human iPS cells. Nat Methods 8(5):409–412
Yang B et al (2012) Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix - based scaffold. Biomaterials 33(8):2449–2461
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Yildirim, S. (2013). Conclusions. In: Dental Pulp Stem Cells. SpringerBriefs in Stem Cells. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5687-2_10
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DOI: https://doi.org/10.1007/978-1-4614-5687-2_10
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