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Epidemiology of Breast Cancer in Women

  • Steven S. Coughlin
  • Yasmin Cypel
Chapter

Abstract

Epidemiologic studies have contributed importantly to current knowledge of environmental and genetic risk factors for breast cancer. Worldwide, breast cancer is an important cause of human suffering and premature mortality among women. In the United States, breast cancer accounts for more cancer deaths in women than any site other than lung cancer. A variety of risk factors for breast cancer have been well-established by epidemiologic studies including race, ethnicity, family history of cancer, and genetic traits, as well as modifiable exposures such as increased alcohol consumption, physical inactivity, exogenous hormones, and certain female reproductive factors. Younger age at menarche, parity, and older age at first full-term pregnancy may influence breast cancer risk through long-term effects on sex hormone levels or by other biological mechanisms. Recent studies have suggested that triple negative breast cancers may have a distinct etiology. Genetic variants and mutations in genes that code for proteins having a role in DNA repair pathways and the homologous recombination of DNA double stranded breaks (BRCA1, BRCA2, XRCC2, XRCC3, ATM, CHEK2, PALB2, RAD51), have been implicated in some cases of breast cancer.

Keywords

Incidence International trends Risk factors Anthropometric factors Mammographic breast density Ionizing radiation exposure Environmental exposures Genetic factors Gene mutations Genetic polymorphisms Family history Race 

References

  1. 1.
    Coughlin SS, Ekwueme DU (2009) Breast cancer as a global health concern. Cancer Epidemiol 33:315–318PubMedCrossRefGoogle Scholar
  2. 2.
    American Cancer Society (2011) Global cancer facts and figures, 2nd edn. American Cancer Society, AtlantaGoogle Scholar
  3. 3.
    American Cancer Society (2011b) Breast cancer facts and figures 2011–2012. American Cancer Society, AtlantaGoogle Scholar
  4. 4.
    Miao H, Verkooijen HM, Chia KS, Bouchardy C, Pukkala E, Laronningen S, Mellemkjaer L, Czene K, Hartman M (2011) Incidence and outcome of male breast cancer: an international population-based study. J Clin Oncol 29:4381–4386PubMedCrossRefGoogle Scholar
  5. 5.
    Joslyn SA, Foote ML, Nasseri K, Coughlin SS, Howe HL (2005) Racial and ethnic disparities in breast cancer rates by age: NAACCR breast cancer project. Breast Cancer Res Treat 92:97–105PubMedCrossRefGoogle Scholar
  6. 6.
    Wingo PA, King J, Swan J, Coughlin SS, Kaur JS, Erb-Alvarez JA, Jackson-Thompson J, Arambula Solomon TG (2008) Breast cancer incidence among American Indian and Alaska Native women: US, 1999–2004. Cancer 113(5):1191–1202PubMedCrossRefGoogle Scholar
  7. 7.
    DeSantis C, Howlader N, Cronin KA, Jemal A (2011) Breast cancer incidence rates in US women are no longer declining. Cancer Epidemiol Biomarkers Prev 20:733–799PubMedCrossRefGoogle Scholar
  8. 8.
    Anderson WF, Katki HA, Rosenberg PS (2011) Incidence of breast cancer in the United States: current and future trends. J Natl Cancer Inst 21:1397–1402CrossRefGoogle Scholar
  9. 9.
    Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJL, Naghavi M (2011) Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 378:1461–1484PubMedCrossRefGoogle Scholar
  10. 10.
    James RE, Lukanova A, Dossus L et al (2011) Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. Cancer Prev Res 4:1626–1635CrossRefGoogle Scholar
  11. 11.
    Endogenous Hormones and Breast Cancer Collaborative Group (2011) Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer 105:709–722CrossRefGoogle Scholar
  12. 12.
    Coughlin SS, Richardson LS, Orelien J, Thompson T, Richards TB, Sabatino SA, Wu W, Conney D (2009) Contextual analysis of breast cancer stage at diagnosis among women in the United States, 2004. Open Health Services Policy J 2:45–46Google Scholar
  13. 13.
    Dunn BK, Agurs-Collins T, Browne D, Lubet R, Johnson KA (2010) Health disparities in breast cancer: biology meets socioeconomic status. Breast Cancer Res Treat 121:281–292PubMedCrossRefGoogle Scholar
  14. 14.
    Russo J, Moral R, Balogh GA, Mailo D, Russo IH (2005) The protective role of pregnancy in breast cancer. Breast Cancer Res 7:131–142PubMedCrossRefGoogle Scholar
  15. 15.
    Jatoi I, Anderson WF (2010) Qualitative age interactions in breast cancer studies: a mini-review. Future Oncol 6:1781–1788PubMedCrossRefGoogle Scholar
  16. 16.
    Opdahl S, Alsaker MD, Jansky I, Romundstad PR, Vatten LJ (2011) Joint effects of nulliparity and other breast cancer risk factors. Br J Cancer 105:731–736PubMedCrossRefGoogle Scholar
  17. 17.
    Palmer JR, Boggs DA, Wise LA, Ambrosone CB, Adams-Campbell LL, Rosenberg L (2011) Parity and lactation in relation to estrogen receptor negative breast cancer in African American women. Cancer Epidemiol Biomarkers Prev 20:1883–1891PubMedCrossRefGoogle Scholar
  18. 18.
    Marchbanks PA, Curtis KM, Mandel MG, Wilson HG, Jeng G, Folger SG, McDonald JA, Daling JR, Bernstein L, Malone KE, Wingo PA, Simon MS, Norman SA, Strom BL, Ursin G, Weiss LK, Burkman RT, Spirtas R (2012) Oral contraceptive formulation and risk of breast cancer. Contraception 85:342–350Google Scholar
  19. 19.
    Calle EE, Feigelson HS, Hildebrand JS, Teras LR, Thun MJ, Rodriguez C (2009) Postmenopausal hormone use and breast cancer associations differ by hormone regimen and histologic subtype. Cancer 115:936–945PubMedCrossRefGoogle Scholar
  20. 20.
    Reeves GK, Beral V, Green J, Gathani T, Bull D, Million Women Study Collaborators (2006) Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis. Lancet Oncol 7:910–918Google Scholar
  21. 21.
    Chlebowski RT, Hendrix SL, Langer RD et al (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s health initiative randomized trial. JAMA 289:3243–3253PubMedCrossRefGoogle Scholar
  22. 22.
    Pelucchi C, Levi F, La Vecchia C (2010) The rise and fall in menopausal hormone therapy and breast cancer incidence. Breast 19:198–201PubMedCrossRefGoogle Scholar
  23. 23.
    Breen N, Cronin KA, Tiro JA, Meissner HI, McNeel TS, Sabatino SA, Tangka FK, Taplin SH (2011) Was the drop in mammography rates in 2005 associated with the drop in hormone therapy use? Cancer 117:5450–5460PubMedCrossRefGoogle Scholar
  24. 24.
    Chen WY, Rosner B, Hankinson SE, Colditz GA, Willett WC (2011) Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 306:1884–1890PubMedCrossRefGoogle Scholar
  25. 25.
    Hamajima N, Hirose K, Tajima K et al Collaborative Group on Hormonal Factors in Breast Cancer (2002) Alcohol, tobacco and breast cancer: collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 87:1234–1245Google Scholar
  26. 26.
    Tjonneland A, Christensen J, Olsen A et al (2007) Alcohol intake and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). Cancer Causes Control 18:361–373PubMedCrossRefGoogle Scholar
  27. 27.
    Dong JY, Qin LQ (2011) Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125:315–323PubMedCrossRefGoogle Scholar
  28. 28.
    Pan SY, Zhou J, Gibbons L, Morrison H, Wen SW (2011) Antioxidants and breast cancer risk—a population-based case-control study in Canada. BMC Cancer 11:372PubMedCrossRefGoogle Scholar
  29. 29.
    Donaldson MS (2004) Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr J 3:19PubMedCrossRefGoogle Scholar
  30. 30.
    Sieri S, Pala V, Brighenti F, Pellegrini N, Muti P, Micheli A, Evangelista A, Grioni S, Contiero P, Berrino F, Krogh V (2007) Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study. Am J Clin Nutr 86:1160–1166PubMedGoogle Scholar
  31. 31.
    Lajous M, Boutron-Ruault MC, Fabre A, Clavel-Chapelon F, Romieu I (2008) Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am J Clin Nutr 87:1384–1391PubMedGoogle Scholar
  32. 32.
    Shikany JM, Redden DT, Neuhouser ML, Chlebowski RT, Rohan TE, Simon MS, Liu S, Lane DS, Tinker L (2011) Dietary glycemic load, glycemic index, and carbohydrates and risk of breast cancer in the women’s health initiative. Nutr Cancer 63:899–907PubMedCrossRefGoogle Scholar
  33. 33.
    Jonas CR, McCullough ML, Teras LR, Walker-Thurmond KA, Thun MJ, Calle EE (2003) Dietary glycemic index, glycemic load, and risk of incident breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 12:573–577PubMedGoogle Scholar
  34. 34.
    Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM (2008) Dietary glycaemic index, glycaemic load and breast cancer risk: a systematic review and meta-analysis. Br J Cancer 99:1170–1175PubMedCrossRefGoogle Scholar
  35. 35.
    Friedenreich CM, Neilson HK, Lynch BM (2010) State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer 46:2593–2604PubMedCrossRefGoogle Scholar
  36. 36.
    McTiernan A, Kooperberg C, White E, Wilcox S, Coates R, Adams-Campbell LL, Woods N, Ockene J (2003) Recreational physical activity and the risk of breast cancer in postmenopausal women. The women’s health initiative cohort study. JAMA 290:1331–1336PubMedCrossRefGoogle Scholar
  37. 37.
    Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371:569–578PubMedCrossRefGoogle Scholar
  38. 38.
    Green J, Cairns BJ, Casabonne D, Wright FL, Reeves G, Beral V (2011) Height and cancer incidence in the million women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk. Lancet Oncol 12:785–794PubMedCrossRefGoogle Scholar
  39. 39.
    McTiernan A, Ulrich C, Slate S, Potter J (1998) Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9:487–509PubMedCrossRefGoogle Scholar
  40. 40.
    Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med 348:1625–1638PubMedCrossRefGoogle Scholar
  41. 41.
    Feigelson HS, Jonas CR, Teras LR, Thun MJ (2004) Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev 13:220–224PubMedCrossRefGoogle Scholar
  42. 42.
    Baer HJ, Tworoger SS, Hankinson SE, Willet WC (2010) Body fatness at young ages and risk of breast cancer throughout life. Am J Epidemiol 171:1183–1194PubMedCrossRefGoogle Scholar
  43. 43.
    Bruning PF, Bonfrer JM, van Noord PA, Hart AA, de Jong-Bakker M, Nooijen WJ (1992) Insulin resistance and breast cancer risk. Int J Cancer 52:511–516PubMedCrossRefGoogle Scholar
  44. 44.
    Talamini R, Franceschi S, Favero A, Negri E, Parazzini F, LaVecchia C (1997) Selected medical conditions and risk of breast cancer. Br J Cancer 75:1699–1703PubMedCrossRefGoogle Scholar
  45. 45.
    Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351:1393–1396PubMedCrossRefGoogle Scholar
  46. 46.
    Endogenous Hormones and Breast Cancer Collaborative Group (2010) Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol 11:530–542CrossRefGoogle Scholar
  47. 47.
    Rinaldi S, Toniolo P, Muti P et al (2005) IGF-I, IGFBP-3 and breast cancer in young women: a pooled reanalysis of three prospective studies. Eur J Cancer Prev 14:493–496PubMedCrossRefGoogle Scholar
  48. 48.
    Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB (2011) Body size across the life course, mammographic density, and risk of breast cancer. Am J Epidemiol 174:909–918PubMedCrossRefGoogle Scholar
  49. 49.
    Boyd NF, Martin LJ, Yaffe MJ, Minkin S (2011) Mammographic density and breast cancer risk: current understanding and future prospects. Breast Cancer Res 13:223PubMedCrossRefGoogle Scholar
  50. 50.
    Boyd NF, Melnichouk O, Martin LJ, Hislop G, Chiarelli AM, Yaffe MJ, Minkin S (2011) Mammographic density, response to hormones, and breast cancer risk. J Clin Oncol 29:2985–2992PubMedCrossRefGoogle Scholar
  51. 51.
    Maskarinec G, Pagano I, Lurie G, Kolonel LN (2006) A longitudinal investigation of mammographic density: the multiethnic cohort. Cancer Epidemiol Biomark Prev 15:732–739CrossRefGoogle Scholar
  52. 52.
    Land CE (1995) Studies of cancer and radiation dose among atomic bomb survivors: the example of breast cancer. JAMA 274:402–407PubMedCrossRefGoogle Scholar
  53. 53.
    Hancock SL, Tucker MA, Hoppe RT (1993) Breast cancer after treatment of Hodgkin’s disease. J Natl Cancer Inst 85:25–31PubMedCrossRefGoogle Scholar
  54. 54.
    Institute of Medicine (2012) Breast cancer and the environment: a life course approach. The National Academies Press, WashingtonGoogle Scholar
  55. 55.
    Boffetta P, Mundt KA, Adami H-O, Cole P, Mandel JS (2011) TCDD and cancer: a critical review of epidemiologic studies. Critical Rev Toxicol 41:622–636CrossRefGoogle Scholar
  56. 56.
    Schernhammer ES, Laden F, Speizer FE, Willet WC, Hunter DJ, Kawachi I, Colditz GA (2001) Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study. J Natl Cancer Inst 93:1563–1568PubMedCrossRefGoogle Scholar
  57. 57.
    Blask DE, Hill SM, Dauchy RT, Xiang S, Yuan L, Duplessis T, Mao L, Dauchy E, Sauer LA (2011) Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. J Pineal Res 51:259–269PubMedCrossRefGoogle Scholar
  58. 58.
    Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM (2011) DNA methylation in white blood cells. Association with risk factors in epidemiologic studies. Epigenetics 6:828–837PubMedCrossRefGoogle Scholar
  59. 59.
    Phipps AI, Buist DS, Malone KE, Barlow WE, Porter PL, Kerlikowske K, Li CI (2011) Reproductive history and risk of three breast cancer subtypes defined by three biomarkers. Cancer Causes Control 22:399–405PubMedCrossRefGoogle Scholar
  60. 60.
    de Ruijter TC, Veeck J, de Hoon JPJ, van Engeland M, Tjan-Heijnen VC (2011) Characteristics of triple-negative breast cancer. J Cancer Res Clin Oncol 137:183–192PubMedCrossRefGoogle Scholar
  61. 61.
    Yang XR, Chang-Claude J, Goode EL et al (2011) Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the breast cancer association consortium studies. J Natl Cancer Inst 103:250–263PubMedCrossRefGoogle Scholar
  62. 62.
    Davis AA, Kaklamani VG (2012) Metabolic syndrome and triple-negative breast cancer: a new paradigm. Int J Breast CancerGoogle Scholar
  63. 63.
    Mavaddat N, Antoniou AC, Easton DF, Garcia-Closas M (2010) Genetic susceptibility to breast cancer. Mol Oncol 4:174–191PubMedCrossRefGoogle Scholar
  64. 64.
    Coughlin SS, Khoury MJ, Steinberg KK (1999) BRCA1 and BRCA2 gene mutations and risk of breast cancer. Public health perspectives. Am J Prev Med 16:91–98PubMedCrossRefGoogle Scholar
  65. 65.
    Newman B, Millikan RC, King M-C (1997) Genetic epidemiology of breast and ovarian cancers. Epidemiol Rev 19:69–79PubMedCrossRefGoogle Scholar
  66. 66.
    Anderson TI (1996) Genetic heterogeneity in breast cancer susceptibility. Acta Oncol 35:407–410CrossRefGoogle Scholar
  67. 67.
    Zhang B, Beeghly-Fadiel A, Long J, Zheng W (2011) Genetic variants associated with breast-cancer risk: Comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol 12:477–488PubMedCrossRefGoogle Scholar
  68. 68.
    Lin WY, Camp NJ, Cannon-Albright LA et al (2011) A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet 48:477–484PubMedCrossRefGoogle Scholar
  69. 69.
    Silva SN, Tomar M, Paulo C, Gomes BC, Azevedo AP, Teixeira V, Pina JE, Rueff J, Gaspar JF (2010) Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. Cancer Epidemiol 34:85–92PubMedCrossRefGoogle Scholar
  70. 70.
    Fulda S (2009) Caspase-8 in cancer biology and therapy. Cancer Lett 281:128–133PubMedCrossRefGoogle Scholar
  71. 71.
    Turnbull C, Rahman N (2008) Genetic predisposition to breast cancer: past, present, and future. Annu Rev Genomics Hum Genet 9:321–345PubMedCrossRefGoogle Scholar
  72. 72.
    Antoniou A, Pharoah PD, Narod S et al (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72:1117–1130PubMedCrossRefGoogle Scholar
  73. 73.
    Begg CB, Haile RW, Borg A et al (2008) Variation of breast cancer risk among BRCA1/2 carriers. JAMA 299:194–201PubMedCrossRefGoogle Scholar
  74. 74.
    Ricks-Santi LJ, Sucheston LE, Yang Y, Freudenheim JL, Isaacs CJ, Schwartz MD, Dumitrescu RG, Marian C, Nie J, Vito D, Edge SB, Shields PG (2011) Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk. BMC Cancer 11:278PubMedCrossRefGoogle Scholar
  75. 75.
    Rebbeck TR, Mitra N, Domchek SM et al (2011) Modification of BRCA1-associated breast and ovarian cancer risk by BRCA1-interacting genes. Cancer Res 71:5792–5805PubMedCrossRefGoogle Scholar
  76. 76.
    Wang X, Pankratz VS, Fredericksen Z et al (2010) Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 19:2886–2897PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Epidemiology Program, Office of Public HealthDepartment of Veterans AffairsWashington, DCUSA
  2. 2.Department of EpidemiologyRollins School of Public Health, Emory UniversityAtlantaUSA

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