Stress-Related Disease: A Review

  • George S. EverlyJr.
  • Jeffrey M. Lating


There has been skepticism that emotions aroused in a social context can so seriously affect the body as to lead to long-term disease or death. But the work, such as that of Wolf, shows that machinery of the human body is very much at the disposal of the higher centers of the brain…. Given the right circumstances, these higher controls can drive it mercilessly, often without awareness on the part of the individual of how close he is to the fine edge. (Henry & Stephens, 1977, p. 11)


Human Immunodeficiency Virus Natural Killer Cell Major Depressive Disorder Irritable Bowel Syndrome Acquire Immune Deficiency Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abbas, A. K., & Lichtman, A. H. (2011). Basic Immunology updated edition: Functions and disorders of the immune system. Philadelphia, PA: Elsevier Saunders.Google Scholar
  2. Almy, T. P., Kern, F., & Tulin, M. (1949). Alterations in colonic function in man under stress. Gastroenterology, 12, 425–436.PubMedGoogle Scholar
  3. Amkraut, A., & Solomon, G. (1974). From symbolic stimulus to the pathophysiologic response: Immune mechanisms. International Journal of Psychiatry in Medicine, 5, 541–563.PubMedCrossRefGoogle Scholar
  4. Anisman, H. (2009). Cascading effects of stressors and inflammatory immune system activation: Implications for major depressive disorder. Journal of Psychiatry & Neuroscience, 34(1), 4–20.Google Scholar
  5. Antoni, M. H., Schneiderman, N., Fletcher, M. A., Goldstein, D. A., Ironson, G., & Laperriere, A. (1990). Psychoneuroimmunology and HIV-1. Journal of Consulting and Clinical Psychology, 58(1), 38–49.PubMedCrossRefGoogle Scholar
  6. Backus, F., & Dudley, D. (1977). Observations of psychosocial factors and their relationship to organic disease. In Z. J. Lipowski, D. Lipsitt, & P. Whybrow (Eds.), Psychosomatic medicine (pp. 187–205). New York, NY: Oxford University Press.Google Scholar
  7. Bartrop, R. W., Luckhurst, E., Lazarus, L., Kiloh, L. G., & Penny, R. (1977). Depressed lymphocyte function after bereavement. Lancet, 1, 834–836.PubMedCrossRefGoogle Scholar
  8. Berk, L. (1989a). Eustress of mirthful laughter modifies natural killer cell activity. Clinical Research, 37, 115.Google Scholar
  9. Berk, L. (1989b). Neuroendocrine and stress hormone changes during mirthful laughter. American Journal of Medical Science, 298, 390–396.CrossRefGoogle Scholar
  10. Bohus, B., & Koolhaas, J. M. (1991). Psychoimmunology of social factors in rodents and other subprimate vertebrates. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (2nd ed., pp. 807–830). New York, NY: Academic Press.Google Scholar
  11. Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., & Maes, M. (2002). Increased depressive ratings in patients with hepatitis C receiving interferon-[alpha]-based immunotherapy are related to interferon-[alpha]-induced changes in the serotonergic system. Journal of Clinical Psychopharmacology, 22(1), 86–90.PubMedCrossRefGoogle Scholar
  12. Borysenko, M. (1987). The immune system. Annals of Behavioral Medicine, 9, 3–10.CrossRefGoogle Scholar
  13. Brown, G. W. (1972). Life events and psychiatric illness. Journal of Psychosomatic Research, 16, 311–320.PubMedCrossRefGoogle Scholar
  14. Campernolle, T., Kees, H., & Leen, J. (1979). Diagnosis and treatment of the hyperventilation syndrome. Psychosomalics, 20, 612–625.Google Scholar
  15. Capuron, L., Gumnick, J. F., Musselman, D. L., Lawson, D. H., Reedmsnyder, A., Nemeroff, C. B., & Miller, A. H. (2002). Neurobehavioral effects of interferon-α in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology, 26(5), 643–652.PubMedCrossRefGoogle Scholar
  16. Capuron, L., Ravaud, A., & Dantzer, R. (2000). Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon-alfa-2b therapy. Journal of Clinical Oncology, 18(10), 2143–2151.PubMedGoogle Scholar
  17. Cohen, S., & Herbert, T. B. (1996). Health psychology: Psychological factors and physical disease from the perspective of human psychoneuroimmunology. Annual Review of Psychology, 47, 113–142.PubMedCrossRefGoogle Scholar
  18. Crook, T. H., & Miller, N. E. (1985). The challenge of Alzheimer’s disease. American Psychologist, 40(11), 1245–1250.PubMedCrossRefGoogle Scholar
  19. Cunnick, J. E., Lysle, D. T., Armfield, A., & Rabin, B. S. (1988). Shock induced modulation of lymphocyte responsiveness and natural killer cell activity: Differential mechanisms of ­induction. Brain, Behavior, and Immunity, 2, 102–112.PubMedCrossRefGoogle Scholar
  20. Dillon, K., & Baker, K. (1985). Positive emotional states and enhancement of the immune system. International Journal of Psychiatric Medicine, 5, 13–18.CrossRefGoogle Scholar
  21. Dirkzwager, A. J. E., van der Velden, P. G., Grievink, L., & Yzermans, J. (2007). Disaster-related posttraumatic stress disorder and physical health. Psychosomatic Medicine, 69, 435–440.PubMedCrossRefGoogle Scholar
  22. Dorpat, T. L., & Holmes, T. H. (1955). Mechanisms of skeletal muscle pain and fatigue. Archives of Neurology and Psychiatry, 74, 628–640.PubMedCrossRefGoogle Scholar
  23. Dotevall, G. (1985). Stress and the common gastrointestinal disorders. New York, NY: Praeger.Google Scholar
  24. Dunn, A. J. (1989). Psychoneuroimmunology for the psychoneuroendocrinologist: A review of animal studies of nervous-immune system interactions. Psychoneuroendocrinology, 14, 251–274.PubMedCrossRefGoogle Scholar
  25. Eisler, R., & Polak, P. (1971). Social stress and psychiatric disorder. Journal of Nervous and Mental Disease, 153, 227–233.PubMedCrossRefGoogle Scholar
  26. Eliot, R. (1979). Stress and the major cardiovascular diseases. Mt. Kisco, NY: Futura.Google Scholar
  27. Eller, L. S. (1996). Effects of two cognitive-behavioral interventions on immunity and symptoms in persons with HIV. Annals of Behavioral Medicine, 17, 339–348.Google Scholar
  28. Engels, W. (1985). Dermatological disorders. In W. Dorftnan & L. Cristofar (Eds.), Psychosomatic illness review (pp. 146–161). New York, NY: Macmillan.Google Scholar
  29. Epstein, S., & Coleman, M. (1970). Drive theories of schizophrenia. Psychosomatic Medicine, 32, 114–141.Google Scholar
  30. Erdman, L. (1993). Laughter therapy for patients with cancer. Journal of Psychosocial Oncology, 11(4), 55–67.CrossRefGoogle Scholar
  31. Esterling, B. A., Kiecolt-Glaser, J. K., Bodnar, J. C., & Glaser, R. (1994). Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults. Health Psychology, 13(4), 291–298.PubMedCrossRefGoogle Scholar
  32. Esterling, B. A., Kiecolt-Glaser, J. K., & Glaser, R. (1996). Psychosocial modulation of cytokine-induced natural killer cell activity in older adults. Psychosomatic Medicine, 58, 264–272.PubMedGoogle Scholar
  33. Everly, G. S., Jr. (1985b, November). Biological foundations of psychiatric sequelae in trauma and stress-related “disorders of arousal.” Paper presented to the 8th National Trauma Symposium, Baltimore, MD.Google Scholar
  34. Everly, G. S., Jr., & Lating, J. M. (2004). Personality guided therapy of posttraumatic stress disorder. Washington, DC: American Psychological Association.CrossRefGoogle Scholar
  35. Fleshner, M., Laudenslager, M. L., Simons, L., & Maier, S. F. (1989). Reduced serum antibodies associated with social defeat in rats. Physiology and Behavior, 42, 485–489.Google Scholar
  36. Folks, D. G., & Kinney, F. C. (1995). Dermatologic conditions. In A. Stoudemire (Ed.), Psychological factors affecting medical conditions (pp. 123–140). Washington, DC: American Psychiatric Press.Google Scholar
  37. Ganong, W. F. (1997). Review of medical physiology (18th ed.). Stamford, CT: Appleton & Lange.Google Scholar
  38. Gaynes, B. N., Pence, B. W., Eron, J. J., Jr., & Miller, W. C. (2008). Prevalence and comorbidity of psychiatric diagnoses based on reference standard in and HIV+ patient population. Psychosomatic Medicine, 70(4), 505–511.PubMedCrossRefGoogle Scholar
  39. Gellhorn, E. (1967). Principles of autonomic-somatic integrations. Minneapolis, MN: University of Minnesota Press.Google Scholar
  40. Gellhorn, E. (1969). Further studies on the physiology and pathophysiology of the tuning of the central nervous system. Psychosomatics, 10, 94–104.PubMedGoogle Scholar
  41. Girdano, D. A., & Everly, G. S., Jr. (1986). Controlling stress and tension (2nd ed.). Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
  42. Glaser, R., & Kiecolt-Glaser, J. K. (2005). Stress-induced immune dysfunction: Implications for health. Nature Reviews Immunology, 5, 243–251.PubMedCrossRefGoogle Scholar
  43. Glaser, R., Kiecolt-Glaser, J. K., Bonneau, R. H., Malarkey, W., Kennedy, S., & Hughes, J. (1992). Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosomatic Medicine, 54, 22–29.PubMedGoogle Scholar
  44. Goldsby, R. A., Kindt, T. J., & Osborne, B. A. (2000). Kuby immunology. New York, NY: W. H. Freeman.Google Scholar
  45. Grace, W., Seton, P., Wolf, S., & Wolff, H. G. (1949). Studies of the human colon: 1. American Journal of Medical Science, 217, 241–251.CrossRefGoogle Scholar
  46. Graham, J. E., Glaser, R., Loving, T. J., Malarkey, W. B., Stowell, J. R., & Kiecolt-Glaser, J. K. (2009). Cognitive word use during marital conflict and increases in proinflammatory cytokines. Health Psychology, 28(5), 621–630.PubMedCrossRefGoogle Scholar
  47. Greden, J. F. (1974). Anxiety or caffeinism: A diagnostic dilemma. American Journal of Psychiatry, 131, 1089–1092.PubMedGoogle Scholar
  48. Gullette, E. C., Blumenthal, J. A., Babyak, M., Jiang, W., Waugh, R. A., Frid, D. J., & Krantz, D. S. (1997). Effects of mental stress on myocardial ischemia during daily life. Journal of the American Medical Association, 277(19), 1521–1526.PubMedCrossRefGoogle Scholar
  49. Guyton, A. C. (1982). Textbook of medical physiology. Philadelphia, PA: Saunders.Google Scholar
  50. Guyton, A. C., & Hall, J. E. (2006). Guyton and hall textbook of medical physiology with student consult online access (11th ed.). Philadelphia, PA: Elsevier Saunders.Google Scholar
  51. Hall, N. R. S., Anderson, J. A., & O’Grady, M. P. (1994). Stress and immunity in humans: Modifying variables. In R. Glaser & J. K. Kiecolt-Glaser (Eds.), Handbook of human stress and immunity (pp. 183–215). San Diego: Academic Press.Google Scholar
  52. Hall, N. R. S., & O’Grady, M. P. (1991). Psychosocial interventions and immune function. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (2nd ed., pp. 1067–1080). New York, NY: Academic Press.Google Scholar
  53. Hatch, M. C., Wallenstein, S., Beyea, J., Nieves, J. W., & Susser, M. (1991). Cancer raters after the Three Mile Island nuclear accident and proximity of residence to the plant. American Journal of Public Health, 81(6), 719–724.PubMedCrossRefGoogle Scholar
  54. Hatzenbuehler, M. L., O’Cleirigh, C., Grasso, C., Mayer, K., Safren, S., & Bradford, J. (2011). Effect of same-sex marriage laws on health use and expenditures in sexual minority men: A quasi-natural experiment. American Journal of Public Health, 102(2), 285–291.PubMedCrossRefGoogle Scholar
  55. Heisel, J. S. (1972). Life changes as etiologic factors in juvenile rheumatoid arthritis. Journal of Psychosomatic Research, 17, 411–420.CrossRefGoogle Scholar
  56. Henry, J. P., & Stephens, P. (1977). Stress, health, and the social environment. New York, NY: Springer-Verlag.CrossRefGoogle Scholar
  57. Herbert, T. B., & Cohen, S. (1993). Stress and immunity in humans: A meta-analytic review. Psychosomatic Medicine, 55, 364–379.PubMedGoogle Scholar
  58. Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M., & Markowitz, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature, 373, 123–126.PubMedCrossRefGoogle Scholar
  59. Holland, J. C., & Tross, S. (1987). Psychosocial considerations in the therapy of epidemic Kaposi’s sarcoma. Seminars in Oncology, 14, 48–53.PubMedGoogle Scholar
  60. Holmes, T. H., Trenting, T., & Wolff, H. (1951). Lift situations, emotions, and nasal disease. Psychosomatic Medicine, 13, 71–82.PubMedGoogle Scholar
  61. Holmes, T. H., & Wolff, H. G. (1952). Lift situations, emotions and backache. Psychosomatic Medicine, 14, 18–33.PubMedGoogle Scholar
  62. Horberg, M. A., Silverberg, M. J., Hurley, L. B., Townder, W. J., Klein, D. B., Bersoff-Matcha, S., & Dovach, D. A. (2008). Journal of Acquired Immune Deficiency Syndrome, 47,384–390.Google Scholar
  63. Houldin, A. D., Lev, E., Prystowsky, M. B., Redei, E., & Lowery, B. J. (1991). Psychoneuroimmunology: A review of literature. Holistic Nursing Practice, 5(4), 10–21.PubMedGoogle Scholar
  64. Humphrey, J., & Everly, G. S., Jr. (1980). Factor dimensions of stress responsiveness in male and female students. Health Education, 11, 38–39.Google Scholar
  65. Imboden, B. (1994). T lymphocytes and natural killer cells. In D. Stites, A. I. Terr, & T. G. Parslow (Eds.), Basic and clinical immunology (8th ed., pp. 94–104). Norwalk, CT: Appleton & Lange.Google Scholar
  66. Ironson, G., Wynings, C., Schneiderman, N., Baum, A., Rodriguez, M., & Greenwood, D., Fletcher, M. A. (1997). Posttraumatic stress symptoms, intrusive thoughts, loss, and immune function after Hurricane Andrew. Psychosomatic Medicine, 59, 128–141.PubMedGoogle Scholar
  67. Irwin, M., Daniels, M., Smith, T. L., Bloom, E., & Weiner, H. (1987). Life events, depressive symptoms, and immune function. American Journal of Psychiatry, 144, 437–441.PubMedGoogle Scholar
  68. Irwin, M., Lacher, U., & Caldwell, C. (1992). Depression and reduced natural killer cytotoxicity: A longitudinal study of depressed patients and control subjects. Psychological Medicine, 22, 1045–1050.PubMedCrossRefGoogle Scholar
  69. Jacobson, E. (1938). Progressive relaxation. Chicago: University of Chicago Press.Google Scholar
  70. Jacobson, E. (1970). Modern treatment of tense patients. Springfield, IL: Charles C. Thomas.Google Scholar
  71. Jacobson, E. (1978). You must relax. New York, NY: McGraw-Hill.Google Scholar
  72. Jones, M. P., Bartrop, R. W., Forcier, L., & Penny, R. (2010). The long-term impact of bereavement upon spouse health: A 10-year follow-up. Acta Neuropsychiatrica, 22, 212–217.CrossRefGoogle Scholar
  73. Kang, D. H., Coe, C. L., & McCarthy, D. O. (1996). Academic examinations significantly impact immune responses, but not lung function, in healthy and well-managed asthmatic adolescents. Brain, Behavior, and Immunity, 10, 164–181.PubMedCrossRefGoogle Scholar
  74. Kark, J. D., Goldman, S., & Epstein, L. (1995). Iraqi missle attachs on Israel. The association of mortality with a life-threatening stressor. Journal of the American Medical Association, 273(15), 1208–1210.PubMedCrossRefGoogle Scholar
  75. Kemeny, M. E. (1994). Psychoneuroimmunology of HIV infection. Psychiatric Clinics of North America, 17(1), 55–68.PubMedGoogle Scholar
  76. Kemeny, M. E., Weiner, H., Duran, R., Taylor, S. E., Visscher, B., & Fahey, J. L. (1995). Immune system changes after the death of a partner in HIV-positive gay men. Psychosomatic Medicine, 57, 547–554.PubMedGoogle Scholar
  77. Kendall, M. D. (1998). Dying to live: How our bodies fight disease. Cambridge, UK: Cambridge University Press.CrossRefGoogle Scholar
  78. Kiecolt-Glaser, J. K., Dura, J. R., Speicher, C. E., Trask, O. J., & Glaser, R. (1991). Spousal caregivers of dementia victims: Longitudinal changes in immunity and health. Psychosomatic Medicine, S3, 345–362.Google Scholar
  79. Kiecolt-Glaser, J. K., Fisher, L., Ogrocki, P., Stout, J. C., Speicher, C. E., & Glaser, R. (1987). Marital quality, marital disruption, and immune function. Psychosomatic Medicine, 49, 13–34.PubMedGoogle Scholar
  80. Kiecolt-Glaser, J. K., Garner, W., Speicher, C., Penn, G. M., Holliday, J., & Glaser, R. (1984). Psychosocial modifiers of immunocompetence in medical students. Psychosomatic Medicine, 46, 7–13.PubMedGoogle Scholar
  81. Kiecolt-Glaser, J. K., Kennedy, S., Malkoff, S., Fisher, L., Speicher, C. E., & Glaser, R. (1988). Marital discord and immunity in males. Psychosomatic Medicine, 50, 213–229.PubMedGoogle Scholar
  82. Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L, & Glaser, R. (2005) Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62, 1377–1384.PubMedCrossRefGoogle Scholar
  83. Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proccedings of the National Academy of Sciences of the United States, 100(15), 9090–9095.CrossRefGoogle Scholar
  84. Knapp, P. (1982). Pulmonary disorders and psychosocial stress. In W. Farm, I. Karacan, A. Pakorny, & R. Williams (Eds.), Phenomenology and treatment of psychophysiological disorders (pp. 15–34). New York: Spectrum.CrossRefGoogle Scholar
  85. Koolhaas, J. M., & Bohus, B. (1989). Social control in relation to neuroendocrine and immunological responses. In A. Steptoe & A. Appels (Eds.), Stress, personal control and health (pp. 295–304). Chichester, UK: Wiley.Google Scholar
  86. Koolhaas, J. M. & Bohus, B. (1995). Animal models of stress and immunity. In B. E, Leonard & K. Miller (Eds.), Stress, the immune system and psychiatry (pp. 69–83). Chichester, UK: Wiley.Google Scholar
  87. Lachman, S. (1972). Psychosomatic disorders: A behavioristic interpretation. New York: Wiley.Google Scholar
  88. LaPerriere, A. R., Antoni, M. H., Schneiderman, N., Ironson, G., Klimas, N., Caralis, P., & Fletcher, M. A. (1990). Exercise intervention attenuates emotional distress and natural killer cell decrements following notification of positive serologic status for HIV-1. Biofeedback and Self-Regulation, 15, 229–242.PubMedCrossRefGoogle Scholar
  89. LaPerriere, A. R., Fletcher, M. A., Antoni, M. H., Klimas, N. G., Ironson, G., & Schneiderman, N. (1991). Aerobic exercise training in an AIDS risk group. International Journal of Sports Medicine, 12(Suppl. 1), S53–S57.PubMedCrossRefGoogle Scholar
  90. Latimer, P. (1985). Irritable bowel syndrome. In W. Dorfman & L. Cristofar (Eds.), Psychosomatic illness review (pp. 61–75). New York: Macmillan.Google Scholar
  91. Laudenslager, M. L., Fleshner, M., Hofstadter, P., Held, P. E., Simons, L., & Maier, S. F. (1988). Suppression of specific antibody production by inescapable shock: Stability under varying conditions. Brain, Behavior, and Immunity, 2, 92–101.PubMedCrossRefGoogle Scholar
  92. Leor, J., Poole, W. K., & Kloner, R. A. (1996). Sudden cardiac death triggered by an earthquake. New England Journal of Medicine, 334(7), 413–419.PubMedCrossRefGoogle Scholar
  93. Linn, M. W., Linn, B. S., & Jensen, J. (1984). Stressful events, dysphoric mood, and iuume responsiveness. Psychological Reports, 54, 219–222.PubMedCrossRefGoogle Scholar
  94. Lum, L. C. (1975). Hyperventilation: The tip of the iceberg. Journal of Psychosomatic Research, 19, 375–383.PubMedCrossRefGoogle Scholar
  95. Maes, M., & Bonaccorso, S. (2004). Lower activities of serum peptidases predict higher depressive and anxiety levels following interferon-alpha-based immunotherapy in patients with hepatitis c. Acta Psychiatrca Scandinavica, 109(2), 126–131.CrossRefGoogle Scholar
  96. Mahl, C. F., & Brody, E. (1954). Chronic anxiety symptomatology, experimental stress and HCL secretion. Archives of Neurological Psychiatry, 71, 314–325.CrossRefGoogle Scholar
  97. Maier, S. F., Watkins, L. R., & Fleshner, M. (1994). Psychoneuroimmunology: The interface between behavior, brain, and immunity. American Psychologist, 49(12), 1004–1017.PubMedCrossRefGoogle Scholar
  98. Manuck, S. B., Marsland, A. L., Kaplan, J. R., & Williams, J. K. (1995). The pathogenicity of behavior and its neuroendocrine mediation: An example from coronary artery disease. Psychosomatic Medicine, 57(3), 275–283.PubMedGoogle Scholar
  99. McCain, N. L., Gray, D. P., Elswick, R. K., Jr., Robins, J. W., Tuck, I., Walter, J. M., Ketchum, J. M. (2008). A randomized clinical trial of alternative tress management interventions in persons with HIV infection. Journal of Consulting and Clinical Psychology, 76(3), 431–441Google Scholar
  100. McCain, N. L., & Zeller, J. M. (1996). Psychoneuroimmunological studies in HIV disease. Annual Review of Nursing Research, 14, 23–55.PubMedGoogle Scholar
  101. McClelland, D. C., & Cheriff, A. D. (1997). The immunoenhancing effects of humor on secretory IgA and resistance to respiratory infections. Psychology and Health, 12(3), 329–344.CrossRefGoogle Scholar
  102. McDaniel, J. S. (1992). Psychoimmunology: Implications for future research. Southern Medical Journal, 85(4), 388–396.PubMedCrossRefGoogle Scholar
  103. Medansky, R. S. (1971). Emotion and the skin. Psychosomatics, 12, 326–329.PubMedGoogle Scholar
  104. Millon, T., & Everly, G. S., Jr. (1985). Personality and its disorders. New York: Wiley.Google Scholar
  105. Mitchell, C. M., & Drossman, D. (1987). The irritable bowel syndrome. Annals of Behavioral Medicine, 9, 13–18.CrossRefGoogle Scholar
  106. Mittelman, B., & Wolff, H. G. (1942). Emotions and gastroduodenal function. Psychosomatic Medicine, 4, 5–19.Google Scholar
  107. Mittleman, M. A., Maclure, M., Sherwood, J. B., Mulry, R. P., Tofler, G. H., Jacobs, S. C., & Muller, J. E. (1995). Triggering of acute myocardial infarction onset by episodes of anger. Determinants of myocardial infarction onset study investigators. Circulation, 92(7), 1720–1725.Google Scholar
  108. Moore, J. I. (1992). Pharmacology. New York: Springer-Verlag.CrossRefGoogle Scholar
  109. Moran, M. G. (1995). Pulmonary and rheumatologic diseases. In A. Stoudemire (Ed.), Psychological factors affecting medical conditions (pp. 141–158). Washington, DC: American Psychiatric Press.Google Scholar
  110. Moynihan, J. A., Brenner, G. J., Cocke, R., Karp, J. D., Breneman, S. M., Dopp, J. M., Ader, R., Cohen, N., Grota, L. J., & Felten, S. Y. (1994). Stress-induced modulation of immune function in mice. In R. Glaser & J. K. Kiecolt-Glaser (Eds.), Handbook of human stress and immunity (pp. 1–22). New York: Academic Press.Google Scholar
  111. Muller, N., & Ackenheil, M. (1995). The immune system and schizophrenia. In B. Leonard & K. Miller (Eds.), Stress, the immune system and psychiatry (pp. 137–164). Chichester, UK: Wiley.Google Scholar
  112. Musaph, H. (1977). Itching and other dermatoses. In E. Wittower & H. Wames (Eds.), Psychosomatic medicine (pp. 307–316). New York: Harper & Row.Google Scholar
  113. Neidig, J. L., Smith, B. A., & Brashers, D. E. (2003). Aerorbic exercise training for depressive symptoms management in adults living with HIV infection. Journal of the Association of Nurses in AIDS care, 14(2), 30–40.PubMedCrossRefGoogle Scholar
  114. Niaura, R., & Goldstein, M. G. (1995). Cardiovascular disease, Part II: Coronary artery disease and sudden death and hypertension. In A. Stoudemire (Ed.), Psychological factors affecting medical conditions (pp. 39–56). Washington, DC: American Psychiatric Press.Google Scholar
  115. Parslow, T. G. (1994). Lymphocytes and lymphoid tissues. In D. Stites, A. I. Terr, & T. G. Parslow (Eds.), Basic and clinical immunology (8th ed., pp. 22–39). Norwalk, CT: Appleton & Lange.Google Scholar
  116. Paykel, E., Myers, J., Dienelt, M., Klerman, G., Lindenthal, J., & Pepper, J. (1969). Life events and depression: A controlled study. Archives of General Psychiatry, 21, 753–760.PubMedCrossRefGoogle Scholar
  117. Pennebaker, J. W., & Beall, S. K. (1986). Confronting a traumatic event: Toward an understanding of inhibition and disease. Journal of Abnormal Psychology, 95, 274–281.PubMedCrossRefGoogle Scholar
  118. Pennebaker, J. W., Kiecolt-Glaser, J. K., & Glaser, R. (1988). Disclosure of traumas and immune function: Health implications for psychotherapy. Journal of Consulting and Clinical Psychology, 56(2), 239–245.PubMedCrossRefGoogle Scholar
  119. Pennebaker, J. W., Mayne, T. J., & Francis, M. E. (1997). Linguistic predictors of adaptive bereavement. Journal of Personality and Social Psychology, 72(4), 863–871.PubMedCrossRefGoogle Scholar
  120. Pennebaker, J. W., Mehl, M. R., & Niederhoffer, K. G. (2003). Psychological aspects of natural language use: Our words, our selves. Annual Review of Psychology, 54, 547–577.PubMedCrossRefGoogle Scholar
  121. Petrie, K. J., Booth, R. J., & Pennebaker, J. W. (1998). The immunological effects of thought suppression. Journal of Personality and Social Psychology, 75(5), 1264–1272.PubMedCrossRefGoogle Scholar
  122. Petrie, K. J., Fontanilla, I., Thomas, M. G., Booth, R. J., & Pennebaker, J. W. (2004). Effect of written emotional expression on immune function in patients with human immunodeficiency virus infection: A randomized trial. Psychosomatic Medicine, 66(2), 272–275.PubMedCrossRefGoogle Scholar
  123. Potvin, S., Stip, E., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, E. (2008). Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review. Biological Psychiatry, 63, 801–808.PubMedCrossRefGoogle Scholar
  124. Rabkin, J. G. (1982). Stress and psychiatric disorders. In L. Goldberger & S. Brenitz (Eds.), Handbook of stress (pp. 566–584). New York: Free Press.Google Scholar
  125. Raskin, N. (1985). Migraine. In W. Dorfinan & L. Cristofar (Eds.), Psychosomatic illness review (pp. 11–22). New York: Macmillan.Google Scholar
  126. Ravindran, A. V., Griffiths, J., Merali, Z., & Anisman, H. (1995). Lymphocyte subsets associated with major depression and dysthymia: Modification by antidepressant treatment. Psychosomatic Medicine, 57, 555–563.PubMedGoogle Scholar
  127. Rosch, P. J. (1995). Future directions in psychoneuroimmunology: Psychoelectroneuroimmunology? In B. Leonard & K. Miller (Eds.), Stress, the immune system and psychiatry (pp. 206–231). Chichester, UK: Wiley.Google Scholar
  128. Rosenbaum, M. (1985). Ulcerative colitis. In W. Dorfman & L. Cristofar (Eds.), Psychosomatic illness review (pp. 61–75). New York: Macmillan.Google Scholar
  129. Sareen, J., Cox, B. J., Stein, M. B., Afifi, T. O., Fleet, C., & Asmundson, G. J. G. (2007). Physical and mental comorbidity, disability, and suicidal behavior associated with Posttraumatic Stress Disorder in a large community sample. Psychosomatic Medicine, 69, 242–248.PubMedCrossRefGoogle Scholar
  130. Scalori, A., Pozzi, M., Bellia, V., Apale, P., Santamaria, G., Bordoni, T., , Roffi, L. (2005). Interferon-induced depression: prevalence and management. Digestive and Liver Disease, 37(2), 102–107.Google Scholar
  131. Schleifer, S. J., Keller, S. E., Camerino, M., Thornton, J. C., & Stein, M. (1983). Suppression of lymphocyte stimulation following bereavement. Journal of the American Medical Association, 250, 374–377.PubMedCrossRefGoogle Scholar
  132. Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130(4), 601–630.PubMedCrossRefGoogle Scholar
  133. Selye, H. (1936). A syndrome produced by diverse noxious agents. Nature, 138, 32–33.CrossRefGoogle Scholar
  134. Selye, H. (1951). The General Adaptation Syndrome and the gastrointestinal diseases of adaptation. American Journal of Proctology, 2, 167–184.PubMedGoogle Scholar
  135. Selye, H. (1956). The stress of life. New York: McGraw-Hill.Google Scholar
  136. Selye, H. (1976). Stress in health and disease. Boston: Butterworth.Google Scholar
  137. Serban, G. (1975). Stress in schizophrenics and normals. British Journal of Psychiatry, 126, 397–407.PubMedCrossRefGoogle Scholar
  138. Simonton, C., Matthews-Simonton, S., & Sparks, T. (1980). Psychological intervention in the treatment of cancer. Psychosomatics, 21, 226–233.PubMedGoogle Scholar
  139. Sklar, L. S., & Anisman, H. (1979). Stress and coping factors influence tumor growth. Science, 205, 513–515.PubMedCrossRefGoogle Scholar
  140. Solomon, G. F., Segerstrom, S. C., Grohr, P., Kemeny, M., & Fahey, J. (1997). Shaking up immunity: Psychological and immunologic changes after a natural disaster. Psychosomatic Medicine, 59, 114–127.PubMedGoogle Scholar
  141. Stephenson, P. (1977). Physiologic and psychotropic effects of caffeine on man. Journal of the American Dietetic Association, 71, 240–247.PubMedGoogle Scholar
  142. Steplewski, Z., & Vogel, W. H. (1986). Total leukocytes, T cell subpopulation, and natural killer (NK) cell activity in rats exposed to resistant stress. Life Science, 38, 2419–2427.CrossRefGoogle Scholar
  143. Steptoe, A. (1981). Psychological factors in cardiovascular disorders. New York: Academic Press.Google Scholar
  144. Taub, E., & Stroebel, C. (1978). Biofeedback in the treatment of vasonconstrictive syndromes. Biofeedback and Self-Regulation, 3, 363–374.PubMedCrossRefGoogle Scholar
  145. Thibodeau, G. A., & Patton, K. T. (1993). Anatomy and physiology (2nd ed.). St. Louis: Mosby.Google Scholar
  146. Tomita, T. (1975). Action of catecholamines on skeletal muscles. In S. Geigor (Ed.), Handbook of physiology (Vol. 6, pp. 537–552). Washington, DC: American Physiological Society.Google Scholar
  147. U.S. Department of Health and Human Services. (2009). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Retreived from:
  148. Vessey, S. H. (1964). Effects of grouping on levels of circulating antibodies in mice. Proceedings of Social and Experimental Biological Medicine, 115, 252–255.Google Scholar
  149. von Känel, R., Hepp, U., Buddeberg, C., Keel, M., Mica, L., Aschbacher, K., & Schnyder, U. (2006). Altered blood coagulation in patients with posttraumatic stress disorder. Psychosomatic Medicine, 68, 598–604.CrossRefGoogle Scholar
  150. Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Deutsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn, B. H., Saag, M. S., & Shaw, G. M. (1995). Viral dynamics in human immunodeficiency virus type 1 infection. Nature, 373, 117–122.PubMedCrossRefGoogle Scholar
  151. Weiner, H. (1977). Psychobiology and human disease. New York: Elsevier.Google Scholar
  152. Weiner, H., Thaler, M., Reiser, M., & Mirsky, L. (1957). Etiology of duodenal ulcer. Psychosomatic Medicine, 19, 1–10.PubMedGoogle Scholar
  153. Weinstock, L., & Cluse, R. (1987). A focused overview of gastrointestinal physiology. Annals of Behavioral Medicine, 9, 3–6.CrossRefGoogle Scholar
  154. Weiss, J. M. (1968). Effects of coping responses on stress. Journal of Comparative Physiological Psychology, 65, 251–260.CrossRefGoogle Scholar
  155. Weiss, R. S. (1975). Marital separation. New York: Basic Books.Google Scholar
  156. Whitehead, W. E. (1992). Biofeedback treatment of gastrointestinal disorders. Biofeedback and Self Regulation, 77(1), 59–76.CrossRefGoogle Scholar
  157. Wolf, S., & Glass, G. B. (1950). Correlation of conscious and unconscious conflicts with changes in gastric function and structure. In H. G. Wolff & S. Wolf (Eds.), Life stress and bodily disease (pp. 17–35). Baltimore: Williams & Wilkins.Google Scholar
  158. Wolff, H. G. (1963). Headache and other head pain. New York: Oxford University Press.Google Scholar
  159. Wooten, P. (1996). Humor: An antidote for stress. Holistic Nursing Practice, 10(2), 49–56.PubMedGoogle Scholar
  160. Wright, P., Takei, N., Rifkin, L., & Murray, R. M. (1995). Maternal influenza, obstetric complications, and schizophrenia. American Journal of Psychiatry, 152(12), 1714–1720.PubMedGoogle Scholar
  161. Young, L., Richter, J., Bradley, L., & Anderson, K. (1987). Disorders of the upper gastrointestinal system. Annals of Behavioral Medicine, 9, 7–12.CrossRefGoogle Scholar
  162. Zeller, J. M., McCain, N. L., McCann, J. J., Swanson, B., & Colletti, M. A. (1996). Methodological issues in psychoneuroimmunology research. Nursing Research, 45(5), 314–318.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • George S. EverlyJr.
    • 1
  • Jeffrey M. Lating
    • 2
  1. 1.School of MedicineThe Johns Hopkins UniversitySeverna ParkUSA
  2. 2.Loyola University MaylandBaltimoreUSA

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