Abstract
The MHC is a large and stable region mapped to the short arm of the chromosome 6, encoding genes that have a lot of functions in immune and nonimmune response. MHC includes regions for the well-known and the most polymorphic until now discovered gene system, the human leukocyte antigen (HLA) genes. The extreme polymorphism of the HLA system derives from the existence of multiple alleles at several loci. It is estimated that more than 100 million different phenotypes can result from all combinations of alleles in the HLA system [1–5]. HLA genes are autosomal with codominant expression, inherited regularly as a haplotype. Since progeny receives one chromosome (haplotype) from each parent, four combinations of haplotypes are possible in newborn.
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– Rene Descartes
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References
Snell GD, Dausset J, Nathenson S (1976) Histocompatibility. Academic, New York, pp 181–237
Bidwell JL, Navarrete C (eds) (2000) Histocompatibility testing. Imperial College Press, London
Howell MW, Navarrete C (1996) The HLA system: an Update and relevance to patient-donor matching strategies in clinical transplantation. Vox Sang 71:6–12
Tiercy JM (2002) Molecular basis of HLA polymorphism: implications in clinical transplantation. Transpl Immunol 9:173–180
Gruen JR, Weissman SM (1997) Evolving views of the major histocompatibility complex. Blood 90(11):4252–4265
Andric Z, Simonovic R (2003) The HLA system. In: Balint B (ed) Transfusion medicine. CTCI, Belgrade, pp 145–167
Roopenian DC, Simpson E (eds) (2000) Minor histocompatibility antigens: from the laboratory to the clinic. Landis Bioscience, Georgetown
Hviid TV, Hylenius S, Hoegh AM, Kruse C, Christiansen OB (2002) HLA-G polymorphisms in couples with recurrent sponaneous abortions. Tissue Antigens 60:122–132
Charron D (2005) Immunogenomics of hematopoietic stem cell transplantation. Pathol Biol (Paris) 53(3):171–173
Charron D, Suberbielle-Boissel C, Al-Daccak R (2009) Immunogenicity and allogenicity: a challenge of stem cell therapy. J Cardiovasc Transl Res 2(1):130–138
Yen BL, Chang CJ, Liu KJ, Chen YC, Hu HI, Bai CH, Yen ML (2009) Brief report-human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes. Stem Cells 27(2):451–456
Cecka JM (1997) The role of HLA in renal transplantation. Human Imunol 56:6–16
Moore SB (2001) Is HLA matching benefical in liver transplantation? Liver Transplant 7:774–776
Petersdorf EW (2004) HLA matching in allogeneic stem cell transplantation. Curr Opin Hematol 11(6):386–391
Müller CR (2002) Computer applications in the search for unrelated stem cell donors. Transpl Immunol 10:227–240
Koh LP (2004) Unrelated umbilical cord blood transplant in children and adults. Ann Acad Med Singapore 33(5):559–569
Elsner HA, Blasczyk R (2004) Immunogenetics of HLA null alleles: implications for blood stem cell transplant. Tissue Antigens 64(6):687–695
Balint B, Stamatovic D, Andric Z (2003) Stem and progenitor cell transplant. In: Balint B (ed) Transfusion medicine. CTCI, Belgrade, pp 525–547
Balint B, Pavlovic M, Jevtic M, Hrvacevic R, Ostojic G, Ignjatovic L, Mijuskovic Z, Blagojevic R, Trkuljic M (2007) Simple “closed-circuit” group-specific immunoadsorption system for ABO-incompatible kidney transplants. Transf Apher Sci 36:225–233
Balint B, Pavlovic M, Todorovic M, Jevtic M, Ristanovic E, Lj I (2010) The use of simplified ex vivo immunoadsorption and “multi-manner” apheresis in ABO/H-mismatched kidney transplant setting—phase II clinical study. Transf Apher Sci 43(2):141–148
Mazid MA, Kaplan M (1992) An improved affinity support and immunoadsorbent with a synthetic blood group oligosaccharide and polymer coating for hemoperfusion. J Appl Biomater 3(1):9–15
Shishido S, Asanuma H, Tajima E, Hoshinaga K, Ogawa O, Hasegawa A, et al (2002) ABO-incompatible living-donor kidney transplantation in children. Transplantation; 74(2):284–285
Lasky LC, Warkentin PI, Kersey JH, Ramsay NK, McGlave PB, McCullough J (1983) Hemotherapy in patients undergoing blood group incompatible bone marrow transplantation. Transfusion 23(4):277–285
Balint B, Radovic M, Taseski J, Calija B (1986) Investigation of the hydrosoluble type group-specific ABH and Lewis substances. Acta Antropol Yugoslav 23(1):5–12
Terasaki P (1989) Benefical effect of transfusion on kidney transplants. Vox Sang 57:158–160
Burlingam WJ, Solinger HW (1986) Action of donor-specific transfusions - analysis of three possible mechanisms. Transplant Proc 18:685–689
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Pavlovic, M., Balint, B. (2013). The HLA and ABO Systems in the View of Stem Cell Transplant (HLA Typization: Choice of Donors). In: Stem Cells and Tissue Engineering. SpringerBriefs in Electrical and Computer Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5505-9_10
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DOI: https://doi.org/10.1007/978-1-4614-5505-9_10
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