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Gastroesophageal Reflux and the Lung pp 153–174Cite as

Gastroesophageal Reflux in Cystic Fibrosis and Non-CF Bronchiectasis

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Part of the book series: Respiratory Medicine ((RM,volume 2))

Abstract

Gastroesophageal reflux (GER) or the retrograde flow of gastric contents into the esophagus is a physiologic phenomenon that occurs most often after meals and is restricted to the distal esophagus [1, 2]. These occasional GER episodes are of brief duration, cleared rapidly, and generally well tolerated [3]. GER can be accompanied by typical symptoms, like heartburn and regurgitation, but also by atypical symptoms such as noncardiac chest pain, cough, wheezing, and ear, nose, and throat symptoms [1, 2]. Pathological GER or GERD (GER disease) has been described as the increased frequency or duration of exposure of the esophagus to regurgitated gastric contents [4]. Reflux has been clearly associated with the presence of esophagitis and Barrett’s esophagus, and it has also been implied in the pathophysiology of different respiratory disorders [5, 6]. This chapter deals with the literature data on the prevalence, mechanisms, and role of GER in cystic fibrosis as well as in non-CF bronchiectasis.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital Gasthuisberg, Herestraat 49, 701, Leuven, 3000, Belgium

    Ans Pauwels Ph.D.

  2. Upper Gastrointestinal Physiology Unit, Barts and The London School of Medicine and Dentistry, 26 Ashfield Street, London, E1 2AJ, UK

    Daniel Sifrim M.D., Ph.D.

  3. Department of Respiratory Medicine, University Hospital Leuven, 49 Herestraat, 3000, Leuven, Belgium

    Lieven Dupont M.D., Ph.D.

Authors
  1. Ans Pauwels Ph.D.
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  2. Daniel Sifrim M.D., Ph.D.
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  3. Lieven Dupont M.D., Ph.D.
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Correspondence to Lieven Dupont M.D., Ph.D. .

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Editors and Affiliations

  1. , Department of Medicine, University of Wisconsin School of Medici, 600 Highland Avenue, Madison, 53792-9988, Wisconsin, USA

    Keith C. Meyer

  2. , Division of Pulmonary and Critical Care, University of Washington School of Medic, Campus Box 356175, Seatt;e, 98195, Washington, USA

    Ganesh Raghu

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Pauwels, A., Sifrim, D., Dupont, L. (2012). Gastroesophageal Reflux in Cystic Fibrosis and Non-CF Bronchiectasis. In: Meyer, K., Raghu, G. (eds) Gastroesophageal Reflux and the Lung. Respiratory Medicine, vol 2. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5502-8_9

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