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Lens Differentiation from Embryonic Stem (ES) and Induced Pluripotent Stem (iPS) Cells

  • Ales Cvekl
  • Ying Yang
  • Yang Jing
  • Qing Xie
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

The formation of lens progenitor cells and differentiated lens tissue in cell culture conditions presents a number of experimental challenges, even though lens lineage formation and lens fiber cell differentiation are among the best characterized model systems at both genetic and molecular levels. Lens differentiation from ES cells in vitro appears to be a feasible goal. This chapter describes the significance of using ES and iPS cells for better understanding of embryonic lens development and formation of congenital cataracts. A discussion of how iPS cells can help studies of age-related cataract is also included. The chapter summarizes the current data on lentoid body formation from human and primate ES cells, and the molecular basis of directed differentiation of human ES cells into lens progenitor cells and lentoid bodies. Finally, current gaps in lens research and future directions to address these problems are discussed.

Keywords

Embryonic Stem Cell Human Embryonic Stem Cell Lens Epithelial Cell Congenital Cataract Retinal Pigment Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank Dr. Louise Wolf for critical suggestions. We are grateful to Dr. Eric Bouhassira and ES cell core facilities at the Ruth L. and Davis S. Gottesman Institute for Stem Cell Research and Regenerative Medicine of the Albert Einstein College of Medicine for their continuous support. Grant support to AC: R01 EY102200, EY014237 and R21 EY020621. The Department of Ophthalmology and Visual Sciences is supported by an unrestricted grant from Research to Prevent Blindness, Inc.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual SciencesAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of GeneticsAlbert Einstein College of MedicineBronxUSA
  3. 3.Division of Cardiology, Department of MedicineAlbert Einstein College of MedicineBronxUSA

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