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Stem Cell Biology and Regenerative Medicine in Ophthalmology pp 1–29Cite as

The Eye as a Target Organ for Stem Cell Therapy

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Retinal degenerations are a heterogeneous group of disorders that are characterized by progressive cellular dysfunction, cellular disarray, and eventually cell death. Early in the course of disease therapeutic intervention consists of pharmaceutical treatment to prevent cell death or gene therapy to correct the underlying mutation. Due to the nature of pathologies involving these disorders, particularly in late stage of disease, cell replacement therapy or electric stimulation of remaining cells by artificial retinal prosthesis is the only viable option. Stem cell therapies for retinal degenerative diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP) are a promising therapeutic option and will require replacement of lost photoreceptor cells and retinal pigment epithelium (RPE). Current clinical trials are underway to evaluate the potential of stem cell therapy in humans. The use of induced pluripotent stem (iPS) cells hold great promise as a potential reservoir of cells for the treatment of retinal disorders as well as a clinical tool to help understand disease pathology. Advances in stem cell technology will translate these therapies into viable clinical options for the treatment of retinal degenerative diseases and other disorders.

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Authors and Affiliations

  1. Department of Ophthalmology, Albert Florens Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA

    Mark A. Fields, Jie Gong & Lucian V. Del Priore

  2. Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    John Hwang

  3. Harkness Eye Institute, Columbia University, New York, NY, USA

    Hui Cai

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  1. Mark A. Fields
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  2. John Hwang
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  3. Jie Gong
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  4. Hui Cai
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  5. Lucian V. Del Priore
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Correspondence to Lucian V. Del Priore .

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  1. Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University, 160 Fort Washington Avenue, Room 513, New York, 10032, New York, USA

    Stephen H. Tsang

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Fields, M.A., Hwang, J., Gong, J., Cai, H., Del Priore, L.V. (2013). The Eye as a Target Organ for Stem Cell Therapy. In: Tsang, S. (eds) Stem Cell Biology and Regenerative Medicine in Ophthalmology. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5493-9_1

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