Prospects for the Induction of Transplant Tolerance Using Dendritic Cells

  • Matthew Buckland
  • Lesley Smyth
  • Robert Lechler
  • Giovanna Lombardi
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Dendritic cells (DCs) play a key role in both central and peripheral tolerance induction and maintenance. Strategies to modify dendritic cells ex vivo to induce tolerance to an allograft have been extensively studied. Approaches include genetic modification of DCs, siRNA silencing of co-stimulatory pathways and drug modification. The ex vivo approaches are associated with the generation of DCs that can induce hypo-responsiveness in responder T cells and/or the expansion or de novo generation of regulatory T cells. However, in stringent models of transplantation they fail to reliably induce long-term allograft survival. We explore the mechanisms underlying this lack of efficacy and other potential strategies of DC modification including targeting of alloantigens to defined DC subsets such that we have reliable protocols to induce peripheral tolerance.

Keywords

Dendritic Cell Major Histocompatibility Complex Major Histocompatibility Complex Class Treg Cell Major Histocompatibility Complex Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Matthew Buckland
    • 1
  • Lesley Smyth
    • 2
  • Robert Lechler
    • 2
  • Giovanna Lombardi
    • 2
  1. 1.Centre for Immunology and Infectious DiseaseBlizard Institute, Barts and the London School of Medicine and Dentistry, Royal London HospitalLondonUK
  2. 2.Medical Research Council (MRC) Centre for TransplantationKing’s College London, King’s Health Partners, Guy’s HospitalLondonUK

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