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Diabetes pp 62-75 | Cite as

Impairment of Immune Systems in Diabetes

  • Christopher Ting
  • Vivek Bansal
  • Ibrahim Batal
  • Marwan Mounayar
  • Lola Chabtini
  • Ghania El Akiki
  • Jamil Azzi
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that involves the progressive destruction of the insulin-producing β cells in the islets of langerhans. It is a complex process that results from the loss of tolerance to insulin and other β-cell-specific antigens. Various genetic and environmental factors have been studied so far, but precise causation has yet to be established. Numerous studies in rodents and human subjects have been performed in order to elucidate the role of B and T cells, which determine the risk of development and progression of diabetes. These studies have demonstrated that while T1DM is fundamentally a T-cell-mediated autoimmune response, the development of this disease results from complex interactions between the adaptive and innate immune systems, with numerous cell types thought to contribute to pathogenesis. Like any complex disease, the variation in severity and incidence of T1DM can be attributed to a combination of genetic and environmental factors.

Keywords

Major Histocompatibility Complex Natural Killer Cell Beta Cell Human Leukocyte Antigen Major Histocompatibility Complex Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2013

Authors and Affiliations

  • Christopher Ting
    • 1
  • Vivek Bansal
    • 2
  • Ibrahim Batal
    • 1
  • Marwan Mounayar
    • 1
  • Lola Chabtini
    • 1
  • Ghania El Akiki
    • 2
  • Jamil Azzi
    • 1
  1. 1.Transplantation Research Center, Renal Division, BrighamWomen’s Hospital and Children’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Harvard Medical SchoolBeth Israel Deaconess HospitalBostonUSA

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