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Diabetes pp 62–75Cite as

Impairment of Immune Systems in Diabetes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 771))

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that involves the progressive destruction of the insulin-producing β cells in the islets of langerhans. It is a complex process that results from the loss of tolerance to insulin and other β-cell-specific antigens. Various genetic and environmental factors have been studied so far, but precise causation has yet to be established. Numerous studies in rodents and human subjects have been performed in order to elucidate the role of B and T cells, which determine the risk of development and progression of diabetes. These studies have demonstrated that while T1DM is fundamentally a T-cell-mediated autoimmune response, the development of this disease results from complex interactions between the adaptive and innate immune systems, with numerous cell types thought to contribute to pathogenesis. Like any complex disease, the variation in severity and incidence of T1DM can be attributed to a combination of genetic and environmental factors.

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Authors and Affiliations

  1. Transplantation Research Center, Renal Division, Brigham, Women’s Hospital and Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Christopher Ting, Ibrahim Batal, Marwan Mounayar, Lola Chabtini & Jamil Azzi

  2. Harvard Medical School, Beth Israel Deaconess Hospital, Boston, Massachusetts, USA

    Vivek Bansal & Ghania El Akiki

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  1. Christopher Ting
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  2. Vivek Bansal
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  3. Ibrahim Batal
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  4. Marwan Mounayar
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  5. Lola Chabtini
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  6. Ghania El Akiki
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  7. Jamil Azzi
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Correspondence to Jamil Azzi .

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Editors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Nottingham, UK

    Shamim I. Ahmad BSc, MSc, PhD

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Ting, C. et al. (2013). Impairment of Immune Systems in Diabetes. In: Ahmad, S.I. (eds) Diabetes. Advances in Experimental Medicine and Biology, vol 771. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5441-0_8

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