Abstract
Fulminant Type 1 diabetes is a novel subtype of Type 1 diabetes. In this disease, extremely rapid and almost complete β-cell destruction occurs, resulting in nearly no residual insulin secretion even just after the onset. The number of patients presumably amounts to 5,000∼7,000 in Japan. The involvement of both, genetic background and viral infection, has been suggested in the pathogenesis of this disease. Diagnostic criteria were established by a committee of the japan Diabetes Society in 2004. Intensive insulin therapy is a standard therapy. We should pay special attention to early development of microvascular complications in fulminant type 1 diabetes.
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References
Imagawa A, Hanafusa T, Miyagawa J et al. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 2000; 342:301–307.
Hanafusa T, Imagawa A. Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners. Nat Clin Pract Endocrinol Metab 2007; 3:36–45.
Imagawa A, Hanafusa T, Uchigata Y et al. Fulminant type 1 diabetes: a nationwide survey in japan. Diabetes Care 2003; 26:2345–2352.
Imagawa A, Hanafusa T, Uchigata Y et al. Different contribution of class II HLA in fulminant and typical autoimmune type 1 diabetes mellitus. Diabetologia 2005; 48:294–300.
Kawasaki E, Imagawa A, Makino H et al. Differences in the contribution of CTLA4 gene to susceptibility to fulminant and type 1A diabetes in japanese patients. Diabetes Care 2008; 31:1608–1610.
Kawabata Y, Ikegami H, Awata T et al. Differential association ofhla with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset. Diabetologia 2009; 52:2513–2521.
Hanafusa T, Imagawa A, Iwahashi H et al. Report of the Japan Diabetes Society’s committee on research on fulminant type 1 diabetes mellitus: analysis of antiviral antibodies at disease onset. J Japan Diab Soc 2008; 51:531–536.
Shibasaki S, Imagawa A, Tauriainen S et al. Expression of Toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes. Endocrine J 2010; 57:211–219.
Aida K, Nishida Y, tanaka S et al. RIG-and MDA5-initiated innate immunity linked with adaptive immunity accelerates β-cell death in fulminant type 1 diabetes. Diabetes 2011; 60:884–889.
Kotani R, Nagata M, Imagawa A et al. T-lymphocyte response against pancreatic beta cell antigens in fulminant type 1 diabetes Diabetologia 2004; 47:1285–1291.
Tanaka S, Nishida Y, Aida K et al. Enterovirus infection, CXC chemokine ligand 10 (CXCl10) and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes. Diabetes 2009; 58:2285–2291.
Endo T, Takizawa S, Tanaka S et al. Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes. Diabetes 2009; 58:732–737.
Takizawa S, Endo T, Wanjia X et al. HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes. Biochem Biophys Res Commun2009; 386:192–196.
Shibasaki S, Imagawa A, Terasaki J et al. Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes. J Diab Invest 2010; 1:283–285.
Murase Y, Imagawa A, Hanafusa T, et al. Fulminant type 1 diabetes as a high risk group for diabetic microangiopathy-a nationwide 5-year-study in Japan. Diabetologia 2007; 50:531–537.
Sano H, Terasaki J, Mishiba Y et al. Exenatide, glucagon-like peptide-1 receptor agonist suppresses pancreatic β-cell destruction induced by encephalomyocarditis virus. Biochem Biophys Res Commun 2011; 404:756–761.
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© 2013 Landes Bioscience and Springer Science+Business Media
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Shibasaki, S., Imagawa, A., Hanafusa, T. (2013). Fulminant Type 1 Diabetes Mellitus. In: Ahmad, S.I. (eds) Diabetes. Advances in Experimental Medicine and Biology, vol 771. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5441-0_3
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DOI: https://doi.org/10.1007/978-1-4614-5441-0_3
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