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β-Cell Regeneration in Human Pancreas

The Lessons of Pancreatic Pathology

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Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 771))

Abstract

Diabetes mellitus has been traditionally classified as Type 1 and Type 2 on the basis of several criteria that generally reflect either insulin deficiency or functional defects in insulin secretion. In this chapter, we propose a new classification diabetes based on age of onset, body mass index and biomarkers such as islet autoantibodies and DR HLA alleles. In the second part of this chapter, we briefly discuss some novel hypotheses on the possibility of β-cell regeneration in diabetes in relation to the islet pathology of the disease.

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Author information

Authors and Affiliations

  1. The Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Denver, Colorado, USA

    Matthew Maulis

  2. Department of Pediatrics, University of Colorado Denver, Denver, Colorado, USA

    Roberto Gianani

  3. Department of Pathology, University of Colorado Denver, Denver, Colorado, USA

    Roberto Gianani

Authors
  1. Matthew Maulis
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  2. Roberto Gianani
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Corresponding author

Correspondence to Roberto Gianani .

Editor information

Editors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Nottingham, UK

    Shamim I. Ahmad BSc, MSc, PhD

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© 2013 Landes Bioscience and Springer Science+Business Media

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Maulis, M., Gianani, R. (2013). β-Cell Regeneration in Human Pancreas. In: Ahmad, S.I. (eds) Diabetes. Advances in Experimental Medicine and Biology, vol 771. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5441-0_23

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