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Immunoseclusion and Chronic Infection by Borrelia burgdorferi

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Book cover The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence

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Abstract

The subjects of immunoseclusion and chronic infection as pertaining to the Lyme disease pathogen, Borrelia burgdorferi, present challenges not only in developing suitable models for study, but also in the accurate interpretation of experimental findings in the context of human disease. The term immunoseclusion has been described as the property of a pathogen to evade host immunity by hiding itself in sites not typically afforded vasculature, also known as immunologically privileged organs or tissues. The ability of the Lyme disease bacterium to disseminate to and invade host cells and tissues may be a contributing factor for circumventing host defenses. However, any relationship between putative immunoseclusion properties of the Lyme disease agent and chronic infection has not been firmly established.

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  1. Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, 80521, USA

    Robert D. Gilmore Jr. Ph.D.

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  1. Robert D. Gilmore Jr. Ph.D.
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  1. Tulane University Health Sciences Center, Covington, 70433, Louisiana, USA

    Monica E. Embers

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Gilmore, R.D. (2012). Immunoseclusion and Chronic Infection by Borrelia burgdorferi . In: Embers, M. (eds) The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-5404-5_2

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