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TRIM/RBCC Proteins pp 119–129Cite as

MuRFs Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State of Muscle and Its Metabolism

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 770))

Abstract

MuRFs, brief for muscle specific RING finger proteins, correspond to a subfamily of the TRIM/RBCC protein family. Here, we review recent progress on the structural biology of MuRF1, the MuRF family member being most clearly associated with muscle diseases. The emerging understanding of the structural biology of MuRFs and their interaction with their numerous myocellular proteins, at least in part representing ubiquitination targets for MuRFs, is likely to provide future rationales to modulate their activity, thus affecting their roles in muscle disease progression.

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Author information

Authors and Affiliations

  1. School of Biological Sciences, University of Liverpool, Liverpool, UK

    Olga Mayans

  2. Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

    Siegfried Labeit

Authors
  1. Olga Mayans
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  2. Siegfried Labeit
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Editors and Affiliations

  1. Cluster in Biomedicine, CBM S.c.r.l., AREA Science Park, Trieste, Italy

    Germana Meroni Phd

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© 2012 Landes Bioscience and Springer Science+Business Media, LLC

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Mayans, O., Labeit, S. (2012). MuRFs Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State of Muscle and Its Metabolism. In: Meroni, G. (eds) TRIM/RBCC Proteins. Advances in Experimental Medicine and Biology, vol 770. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5398-7_9

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