TRIM Involvement in Transcriptional Regulation

  • Florence Cammas
  • Konstantin Khetchoumian
  • Pierre Chambon
  • Régine Losson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 770)


Members of the tripartite motif (TRIM) protein family are found in all multicellular eukaryotes and function in a wide range of cellular processes such as cell cycle regulation, differentiation, development, oncogenesis and viral response. Over the past few years, several TRIM proteins have been reported to control gene expression through regulation of the transcriptional activity of numerous sequence-specific transcription factors. These proteins include the transcriptional intermediary factor 1 (TIF1) regulators, the promyelocytic leukemia tumor suppressor PML and the RET finger protein (RFP). In this chapter, we will consider the molecular interactions made by these TRIM proteins and will attempt to clarify some of the molecular mechanisms underlying their regulatory effect on transcription.


Promyelocytic Leukemia Heterochromatin Protein Coiled Coil Domain Nuclear Body Stem Cell Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Florence Cammas
    • 1
  • Konstantin Khetchoumian
    • 1
  • Pierre Chambon
    • 1
  • Régine Losson
    • 1
  1. 1.Department of Functional Genomics, Institut de Génétique et de Biologie Moléculaire et CellulaireCNRS/INSERM/ULP/Collège de FranceIllkirchFrance

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