Genomics and Evolution of the TRIM Gene Family

  • Germana Meroni
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 770)


The TRIM family comprises proteins characterized by the presence of the tripartite motif that is composed of a RING domain, one or two B-box domains and a Coiled-coil region. These proteins are implicated in a plethora of cellular processes such as apoptosis, cell cycle regulation, muscular physiology and innate immune response. Consistently, their alteration results in several pathological conditions emphasizing theirmedical relevance. The TRIMmembers domain structure underscores a common biochemical function as E3 ligases within the ubiquitylation cascade, which is then translated into diverse biological processes. The TRIM proteins represent one of the largest families in mammals counting in human almost 70 members. TRIM proteins are metazoan-specific and have been now identified in several species although the great increase in their number was generated in vertebrate species. The important expansion of the number of TRIMgenes underlie the success of the tripartite module in ubiquitylation process. Furthermore, their massive diversification among species was achieved through fast evolution of the TRIM genes implicated in pathogen response.


Major Histocompatibility Complex Ring Domain Trim Protein Tripartite Motif Trim Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Germana Meroni
    • 1
  1. 1.Cluster in BiomedicineCBM S.c.r.lTriesteItaly

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