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Osteoimmunology pp 7–21Cite as

Adaptive Immune Responses and Bone

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Abstract

Effects of the adaptive immune responses on bone have been the central issue in rheumatoid arthritis research, which promoted the development of osteoimmunology. Bone destruction associated with arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper T cell subset “Th17 cells.” The better understanding of the molecular mechanism of Th17 development will lead to the development of potentially effective therapeutic strategies.

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Acknowledgments

I am grateful to Dr. Kazuo Okamoto for the assistance in preparing the manuscript. This work was supported in part by Grants-in-Aid for GCOE Program from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), and ERATO, Takayanagi Osteonetwork Project from JST.

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Authors and Affiliations

  1. Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan

    Hiroshi Takayanagi

  2. Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan

    Hiroshi Takayanagi

  3. Japan Science and Technology Agency (JST), ERATO, Takayanagi Osteonetwork Project, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan

    Hiroshi Takayanagi

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  1. Hiroshi Takayanagi
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Correspondence to Hiroshi Takayanagi .

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Editors and Affiliations

  1. School of Medicine, Dept. Pathology & Lab. Medicine, University of Pennsylvania, Curie Blvd., Philadelphia, 19104, Pennsylvania, USA

    Yongwon Choi

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Takayanagi, H. (2013). Adaptive Immune Responses and Bone. In: Choi, Y. (eds) Osteoimmunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5366-6_3

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