DAP12 Regulates the Osteoclast Cytoskeleton

  • Wei Zou
  • Steven L. Teitelbaum
Conference paper


The primary ITAM-containing signaling adapters, in osteoclast lineage cells, are DAP12 and the FcεRIγ chain (FcRγ). Each associates with specific immunoreceptors. DAP12 associates with the receptors TREM2 and SIRPβ1 [1], while FcRγ recognizes OSCAR [2, 3]. Both molecules also contain an ITAM motif, within their cytoplasmic domains, whose phosphorylated tyrosines provide a high-affinity binding site for Syk family kinases.


Osteoclast Precursor Cytoskeletal Organization Actin Ring Bone Marrow Macrophage Form Actin Ring 
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Copyright information

© Springer New York 2013

Authors and Affiliations

  1. 1.Department of Pathology and ImmunologyWashington University in St. Louis School of MedicineSt. LouisUSA

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