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Squamous Cell Carcinoma

  • Donna E. Hansel
  • Amr Fergany
Chapter

Abstract

In addition to urothelial carcinoma, adenocarcinoma, and small cell carcinoma, squamous cell carcinoma represents a major morphologic subtype of bladder cancer that harbors unique pathogenetic and molecular alterations. In the United States, squamous cell carcinoma affects less than 5 % of all bladder cancer patients, with primary risk factors that include tobacco smoke, long-term catheterization, urinary tract calculi, and a nonfunctioning bladder [1]. A male predominance is common (approximate 3:1 male:female ratio) and patients tend to be older (>60 years of age). Squamous cell carcinoma may also occur in the upper tract, with this form of carcinoma representing up to 10 % of all renal pelvis carcinomas and also likely incited by chronic inflammatory conditions [2–4]. In contrast to the bladder, upper tract squamous cell carcinoma tends to have a roughly equal proportion of men and women affected by the disease [3].

Keywords

Squamous Cell Carcinoma Bladder Cancer Urothelial Carcinoma Squamous Carcinoma Bladder Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of PathologyCleveland ClinicClevelandUSA
  2. 2.Sections of Oncology, Laparoscopy and RoboticsCleveland Clinic, Glickman Urological and Kidney InstituteClevelandUSA

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