Abstract
Dr. Robert Wilson described the rationale for using proton beam therapy for the treatment of cancer as early as 1946. The early proton facilities were mainly physics research laboratories that seldom treated patients with cancer. We now have several dedicated proton facilities for the treatment of cancer. There are several current clinical applications for proton beam therapy including prostate, lung, pediatric, central nervous system cancers and several other malignancies. In properly selected patients, proton beam therapy reduces the dose that is delivered to normal tissues and can reduce both side effects from treatment and the risk of developing secondary malignancies from irradiation. While proton beam therapy is more expensive to deliver than photons, there is cost savings associated with reduced morbidity from treatment and reduced risk of secondary malignancy.
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References
Wilson RR. Radiological use of fast protons. Radiology. 1946;47(5):487–91.
Hall E. Protons for radiotherapy: a 1946 proposal. Lancet Oncol. 2009;10:196.
Suit H. The Gray Lecture 2001: coming technical advances in radiation oncology. Int J Radiat Oncol Biol Phys. 2002;53(4):798–809.
Lawrence JH. Proton irradiation of the pituitary. Cancer. 1957;10:795–8.
Lawrence JH, Tobias CA, Born JL, et al. Pituitary irradiation with high-energy proton beams: a preliminary report. Cancer Res. 1958;18(2):121–34.
Zietman AL, DeSilvio ML, Slater JD, et al. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA. 2005;294(10):1233–9.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29. doi:10.3322/caac.20138 [Epub January 4, 2012].
Chang JY, Komaki R, Wen HY, et al. Toxicity and patterns of failure of adaptive/ablative proton therapy for early stage, medically inoperable non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2011;80(5):1350–7.
Chang JY, Komaki R, Lu C, et al. Phase 2 study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III nonsmall cell lung cancer. Cancer. 2011;117:4707–13.
Lee CT, Bilton SD, Famiglietti RM, et al. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys. 2005;63(2):362–72.
Merchant TE, Hua CH, Shukla H, Ying X, Nill S, Oelfke U. Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood Cancer. 2008;51(1):110–7.
Delaney TF, Kooy HM, editors. Proton and charged particle radiotherapy. Philadelphia: Lippincott Williams and Wilkins; 2008. p. X, 8–9.
Brodin NP, Rosenschöld PM, Aznar MC, et al. Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma. Acta Oncol. 2011;50(6):806–16.
Mu X, Björk-Eriksson T, Nill S, et al. Does electron and proton therapy reduce the risk of radiation induced cancer after spinal irradiation for childhood medulloblastoma? A comparative treatment planning study. Acta Oncol. 2005;44(6):554–62.
Lundkvist J, Ekman M, Ericsson SR, Jönsson B, Glimelius B. Cost-effectiveness of proton radiation in the treatment of childhood medulloblastoma. Cancer. 2005;103(4):793–801.
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Yajnik, S. (2013). An Introduction to Proton Beam Therapy. In: Proton Beam Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5298-0_1
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DOI: https://doi.org/10.1007/978-1-4614-5298-0_1
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