Chapter Overview
Chondrosarcomas constitute a heterogeneous group of rare malignancies that produce a cartilaginous matrix. These tumors exhibit a wide spectrum of clinical behavior. The overwhelming majority are relatively chemo- and radioresistant; therefore, surgery is presently the mainstay of treatment. Intratumoral heterogeneity can confound the determination of an accurate diagnosis, which can result in inappropriate surgery. In the absence of novel effective adjuvant therapies, treatment generally has remained unchanged, and clinical outcomes have been relatively stable for decades. Current issues that remain unresolved include the value of pretreatment biopsy, the role of intralesional curettage of histologically low-grade tumors, the role of adjuvant radiation therapy, and the identification of effective systemic therapies.
Dr. Yasko died during production of this volume. Further revisions to the chapter were made by Vinod Ravi, Ashleigh Guadagnolo, and Patrick P. Lin.
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Bauer HC, Brosjo O, Kreicbergs A, Lindholm J. Low risk of recurrence of enchondroma and low-grade chondrosarcoma in extremities. 80 patients followed for 2–25 years. Acta Orthop Scand. 1995;66:283–8.
Benjamin RS, Chu P, Patel SR, et al. Dedifferentiated chondrosarcoma: a treatable disease. Proc Am Assoc Cancer Res. 1995;36:243 [abstract].
Bertoni F, Bacchini P, Hogendoorn PC. Chondrosarcoma. In: Fletcher CDM, Unni KK, Mertens F, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 247–51.
Bjornsson J, McLeod RA, Unni KK, Ilstrup DM, Pritchard DJ. Primary chondrosarcoma of long bones and limb girdles. Cancer. 1998;83:2105–19.
Cesari M, Bertoni F, Bacchini P, Mercuri M, Palmerini E, Ferrari S. Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. Tumori. 2007;93:423–7.
Dantonello TM, Int-Veen C, Leuschner I, et al. Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer. 2008;112:2424–31.
Dickey ID, Rose PS, Fuchs B, et al. Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 2004;86:2412–8.
Eefting D, Schrage YM, Geirnaerdt MJ, et al. Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors. Am J Surg Pathol. 2009;33:50–7.
Fiorenza F, Abudu A, Grimer RJ, et al. Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br. 2002;84:93–9.
Frassica FJ, Unni KK, Beabout JW, Sim FH. Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases. J Bone Joint Surg Am. 1986;68:1197–205.
Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP. Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg Am. 2009;91:1063–72.
Grimer RJ, Gosheger G, Taminiau A, et al. Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer. 2007;43:2060–5.
Huvos AG. Chondrosarcoma. In: Bone tumors: diagnosis, treatment, and prognosis. 2nd ed. Philadelphia: W.B. Saunders Company; 1991. p. 343–61.
Johnson S, Tetu B, Ayala AG, Chawla SP. Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 cases. Cancer. 1986;58:278–86.
Lee FY, Mankin HJ, Fondren G, et al. Chondrosarcoma of bone: an assessment of outcome. J Bone Joint Surg Am. 1999;81:326–38.
Leerapun T, Hugate RR, Inwards CY, Scully SP, Sim FH. Surgical management of conventional grade I chondrosarcoma of long bones. Clin Orthop Relat Res. 2007;463:166–72.
Lin PP, Alfawareh MD, Takeuchi A, Moon BS, Lewis VO. Sixty percent 10-year survival of patients with chondrosarcoma after local recurrence. Clin Orthop Relat Res. 2012;470:670–6.
Mitchell AD, Ayoub K, Mangham DC, Grimer RJ, Carter SR, Tillman RM. Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br. 2000;82:55–61.
Normand AN, Cannon CP, Lewis VO, Lin PP, Yasko AW. Curettage of biopsy-diagnosed grade 1 periacetabular chondrosarcoma. Clin Orthop Relat Res. 2007;459:146–9.
Pant R, Yasko AW, Lewis VO, Raymond K, Lin PP. Chondrosarcoma of the scapula: long-term oncologic outcome. Cancer. 2005;104:149–58.
Sheth DS, Yasko AW, Johnson ME, Ayala AG, Murray JA, Romsdahl MM. Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery. Cancer. 1996;78:745–50.
Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group. Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones. J Bone Joint Surg Am. 2007;89:2113–23.
Unni KK, Inwards CY. Chondrosarcoma (primary, secondary, dedifferentiated, and clear cell). In: Dahlin’s bone tumors: general aspects and data on 10,165 cases. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010a. p. 60–91.
Unni KK, Inwards CY. Mesenchymal chondrosarcoma. In: Dahlin’s bone tumors: general aspects and data on 10,165 cases. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010b. p. 92–7.
van der Geest IC, de Valk MH, de Rooy JW, Pruszczynski M, Veth RP, Schreuder HW. Oncological and functional results of cryosurgical therapy of enchondromas and chondrosarcomas grade 1. J Surg Oncol. 2008;98:421–6.
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Yasko, A.W., Ravi, V., Guadagnolo, A. (2013). Chondrosarcoma. In: Lin, P., Patel, S. (eds) Bone Sarcoma. MD Anderson Cancer Care Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-5194-5_7
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