Abstract
The incidence of heart failure (HF) patients in the USA is estimated to be around six million, with half a million new cases adding each year) [1, 2]. It is associated with high symptom burden, frequent hospital admissions, diminished quality of life, high costs, and remains the leading cause of death in the USA [3, 4]. It is expected that 70–80 % of patients younger than age 65 will die within 8 years of their HF diagnosis, despite the availability of new medical and surgical options [2]. The evolution of HF in patients is typically characterized by acute crises or exacerbations followed by periods of stability lasting for months or even years. However, these patients are 6–9 times more likely to die of sudden cardiac death than the general population [2]. Several tools are available to help assess the prognosis in advanced HF patients: some are single-item predictors (such as the B-type natriuretic peptide [5], maximal oxygen consumption [6], creatinine level [7], other multivariable models (such as the Seattle Heart Failure Score [7] and the Acute Decompensated Heart Failure National Registry (ADHERE)) [8]. Similarly multiple prognostic factors are associated with increased likelihood of death in advanced HF, especially when coexistent: frequent emergency department visits or hospitalizations, symptoms at rest, dependency in activities of daily living, weight loss ≥ 10 %, albumin 2.5 g/dL, ejection fraction < 20 %, symptomatic arrhythmia, prior cardiopulmonary resuscitation, prior syncope, and embolic stroke. However, even while using these algorithms and other tools, life expectancy remains difficult to predict in advanced HF [3], and this is probably one of the reasons why less than 12 % of these patients benefit from hospice care [4].
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References
Tanner CE, Fromme EK, Goodlin SJ. Ethics in the treatment of advanced heart failure: palliative care and end-of-life issues. Congest Heart Fail. 2011;17(5):235–40.
Hupcey JE, Penrod J, Fenstermacher K. Review article: a model of palliative care for heart failure. Am J Hosp Palliat Care. 2009;26(5):399–404.
Teno JM, Weitzen S, Fennell ML, Mor V. Dying trajectory in the last year of life: does cancer trajectory fit other diseases?J. Palliat Med. 2001;4(4):457–64.
Davis MP. Palliation of heart failure. Am J Hosp Palliat Care. 2005;22:211–22.
Doust JA, Pietrzak E, Sanders S, Glasziou P. How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review. BMJ. 2005;330(7492):625.
Mahon N, Blackstone E, Francis G, et al. The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure. J Am Coll Cardiol. 2002;40:1106–13.
Levi WC, Mozaraffian D, Linker DT, et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation. 2006;113(11):1424–33.
Fonarow GC, Adamas Jr KF, Abraham WT, et al. Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA. 2005;293(5):572–80.
Adler ED, Goldfinger JZ, Kalman J, et al. Palliative care in the treatment of advanced heart failure. Circulation. 2009;120(25):2597–606.
Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation. 2005;112(12):e154–235.
Connor SR, Pyenson B, Fitch K, et al. Comparing hospice and nonhospice patient survival among patients who die within a three-year window. J Pain Symptom Manage. 2007;33(3):238–46.
Emanuel EJ. Cost savings at the end of life. What do the data show? JAMA. 1996;275(24):1907–14.
Pyenson B, Connors S, Fitch K, Kinzbrunner B. Medicare cost in matched hospice and non-hospice cohorts. J Pain Symptom Manage. 2004;28(3):200–10.
Goodlin SJ, Hauptman PJ, Arnold R, et al. Consensus statement: palliative and supportive care in advanced heart failure. J Card Fail. 2004;10(3):200–9.
Sindone AP, Keogh AM, Macdonald PS, et al. Continuous home ambulatory intravenous inotropic drug therapy in severe heart failure: safety and cost efficacy. Am Heart J. 1997;134(5 Pt 1):889–900.
Nauman DJ, Hershberger RE. The use of positive inotropes in end-of-life heart failure care. Curr Heart Fail Rep. 2007;4(3):158–63.
Chua TP, Harrington D, Ponikowski P, et al. Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol. 1997;29(1):147–52.
Johnson MJ, McDonagh TA, Harkness A, et al. Morphine for the relief of breathlessness in patients with chronic heart failure-a pilot study. Eur J Heart Fail. 2002;4:753–6.
Williams SG, Cooke GA, Wright DJ, et al. Peak exercise cardiac power output; a direct indicator of cardiac function strongly predictive of prognosis in chronic heart failure. Eur Heart J. 2001;22:1496–503.
Jennings AL, Davies AN, Higgins JP, Broadley K. Opioids for the palliation of breathlessness in terminal illness. Cochrane Database Syst Rev. 2001;(4):CD002066.
Navigante AH, Cerchietti LC, Castro MA, et al. Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer. J Pain Symptom Manage. 2006;31(1):38–47.
Navigante A, Castro MA, Cerchietti LC. Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated. J Pain Symptom Manage. 2010;39(5):820–30.
Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C. Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev. 2010;(1):CD007354.
Mahler D, Selecki PA, Harrod CG. Management of dyspnea in patients with advanced lung or heart disease: practical guidance from the American college of chest physicians consensus statement. Pol Arch Med Wewn. 2010;120(5):160–6.
Mueller PS, Hook CC, Hayes DL. Ethical analysis of withdrawal of pacemaker or implantable cardioverter-defibrillator support at the end of life. Mayo Clin Proc. 2003;78(8):959–63.
Nohria A, Lewis E, Stevenson LW. Medical management of advanced heart failure. JAMA. 2002;287(5):628–40.
Ebstein AE, DiMarco JP, Ellenbogen KA, et al. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;51(21):e1–62.
Goldstein NE, Mehta D, Siddiqui S, et al. “That’s like an act of suicide” patients’ attitudes toward deactivation of implantable defibrillators. J Gen Intern Med. 2008;23(S1):7–12.
Fromme EK, Stewart TL, Jeppesen M, Tolle SW. Adverse experiences with implantable defibrillators in Oregon hospices. Am J Hosp Palliat Care. 2011;28(5):304–9.
Wilson SR, Givertz MM, Stewart GC, Mudge Jr GH. Ventricular assist devices the challenges of outpatient management. J Am Coll Cardiol. 2009;54(18):1647–59.
Lietz K, Long JW, Kfoury AG, et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation. 2007;116(5):497–505.
Swetz KM, Freeman MR, AbouEzzedine OF, et al. Palliative medicine consultation for preparedness planning in patients receiving left ventricular assist devices as destination therapy. Mayo Clin Proc. 2011;86(6):493–500.
Momen NC, Barclay SI. Addressing ‘the elephant on the table’: barriers to end of life care conversations in heart failure – a literature review and narrative synthesis. Curr Opin Support Palliat Care. 2011;5(4):312–6.
McCarthy M, Hall JA, Ley M. Communication and choice in dying from heart disease. J R Soc Med. 1997;90(3):128–31.
Stuart B, The NHO. Medical guidelines for non-cancer disease and local medical review policy: hospice access for patients with diseases other than cancer. Hosp J. 1999;14(3–4):139–54.
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Appendices
Review Questions
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1.
Which is the global leading cause of death in the USA nowadays?
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(a)
Cancer
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(b)
Heart failure
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(c)
Suicide
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(d)
End-stage pulmonary diseases
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(a)
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2.
What is the best tool to determinate an advanced HF patient prognosis?
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(a)
Single-item tools
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(b)
Multivariate models
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(c)
Prognosis factors
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(d)
All and none of them: prognosis in advanced HF remains difficult
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(a)
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3.
What is the role of opioids in advanced HF?
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(a)
None, the risk of respiratory depression is too high
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(b)
Pain management only
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(c)
Pain management and dyspnea
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(d)
For dyspnea, it works only if associated with benzodiazepines
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(a)
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4.
PM, ICD in patients who are referred to hospice:
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(a)
Both need to be discontinued
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(b)
PM needs to be discontinued
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(c)
ICD needs to be discontinued
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(d)
Both can be maintain and will improve the patient’s quality of life
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(a)
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5.
LVAD as destination therapy:
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(a)
Do not improve the quality of life
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(b)
Do not present with severe complications
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(c)
Are rather cheap
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(d)
Can extend the duration of agony
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(a)
Answers
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1.
(b)
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2.
(d)
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3.
(c)
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4.
(c)
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5.
(d)
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Anwar, D., Anwar, A. (2013). Management of Advanced Heart Failure Patients. In: Vadivelu, N., Kaye, A., Berger, J. (eds) Essentials of Palliative Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5164-8_21
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DOI: https://doi.org/10.1007/978-1-4614-5164-8_21
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