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Mechanisms of Resistance to Radiation

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Principles and Practice of Modern Radiotherapy Techniques in Breast Cancer

Abstract

Radiotherapy is a very effective treatment for achieving local tumor control in breast cancer. However, intrinsic tumor cell radioresistance is a significant clinical problem that limits the results of the treatment. Chemotherapeutics that could specifically sensitize tumors to radiation would greatly increase the ability to deliver higher doses while limiting radiation damage to surrounding normal tissue, but efforts to develop clinically useful tumor radiosensitizers have had limited success.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Ege University, Bornova, Izmir, 35100, Turkey

    Serra Kamer

  2. Department of Radiation Oncology, Marmara University, Pendik, Istanbul, Turkey

    Beste Melek Atasoy

Authors
  1. Serra Kamer
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  2. Beste Melek Atasoy
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Corresponding author

Correspondence to Serra Kamer .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Department of Radiation Oncology, Ege University, Ege Unv. Hastanesi, Izmir, 35100, Turkey

    Ayfer Haydaroglu

  2. Faculty of Medicine, Department of Radiation Oncology, Hacettepe University, Hacettepe Hastanesi, Ankara, 06100, Turkey

    Gokhan Ozyigit

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Kamer, S., Atasoy, B.M. (2013). Mechanisms of Resistance to Radiation. In: Haydaroglu, A., Ozyigit, G. (eds) Principles and Practice of Modern Radiotherapy Techniques in Breast Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5116-7_5

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  • DOI: https://doi.org/10.1007/978-1-4614-5116-7_5

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-5115-0

  • Online ISBN: 978-1-4614-5116-7

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