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Obesity and Chronodisruption: An Imbalance Between Energy Intake and Expenditure

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Chronobiology and Obesity

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Abstract

Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Attempts to understand the causes of obesity and develop new therapeutic strategies have mostly focused on caloric intake and energy expenditure. Recent studies have shown that the circadian clock controls energy homeostasis by regulating circadian expression and/or activity of enzymes, hormones, and transport systems involved in metabolism. Moreover, disruption of circadian rhythms leads to obesity and metabolic disorders. Therefore, it is plausible that resetting of the circadian clock can be used as a new approach to attenuate obesity. Feeding regimens, such as restricted feeding (RF), calorie restriction (CR) and intermittent fasting (IF), provide a time cue and reset the circadian clock and lead to better health. In contrast, high-fat (HF) diet leads to disrupted circadian expression of metabolic factors and obesity. This chapter will focus on chronodisruption and feeding regimens with implications for obesity.

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Authors and Affiliations

  1. The Robert H. Smith Faculty of Agriculture, Food and Environment, Nutrigenomics and Functional Foods Research Center, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, 12, Rehovot, 76100, Israel

    Oren Froy Ph.D.

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  1. Oren Froy Ph.D.
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Correspondence to Oren Froy Ph.D. .

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  1. , Department of Physiology, University of Murcia, Avda. Teniente Flomesta, Murcia, 30100, Spain

    Marta Garaulet

  2. Tufts University School of Medicine, Washington Street 711, Boston, 02115, USA

    Jose M. Ordovás

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Froy, O. (2013). Obesity and Chronodisruption: An Imbalance Between Energy Intake and Expenditure. In: Garaulet, M., Ordovás, J. (eds) Chronobiology and Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5082-5_5

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