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On the Development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge

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Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

Part of the book series: Immunomics Reviews: ((IMMUN,volume 5))

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Abstract

The accumulation of relevant and appropriate data is the essential preliminary to any successful informatics-based exercise in prediction. Without quality data, meaningful prediction is impossible. This is as true in immunobiology as it is in any other branch of the natural sciences. Within the context of vaccine discovery, the accumulation, storage, and retrieval of immunological data within publically accessible repositories, typically web-based databases, is of overwhelming operational importance. Specifically, and with the special reference to the discovery of subunit vaccines, this chapter explores the current state and status of immunological databases focussed on immunogenic proteins, primarily pathogen antigens and environmental allergens. It sets this exploration firmly into context by simultaneously scoping out the rather more mature backdrop provided by epitope-orientated database systems.

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Authors and Affiliations

  1. Bioinformatics Centre, Institute of Microbial Technology, Chandigarh, India

    Hifzur Rahman Ansari & Gajendra P. S. Raghava

  2. School of Life and Health Sciences, Aston University, Birmingham, UK

    Darren R. Flower

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  1. Hifzur Rahman Ansari
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  2. Darren R. Flower
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  3. Gajendra P. S. Raghava
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Correspondence to Darren R. Flower .

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Editors and Affiliations

  1. Aston Pharmacy School, School of Life and Health Sciences, University of Aston, Aston Triangle, Birmingham, B4 7ET, United Kingdom

    Darren R. Flower

  2. Aston Pharmacy School, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom

    Yvonne Perrie

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Ansari, H.R., Flower, D.R., Raghava, G.P.S. (2013). On the Development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge. In: Flower, D., Perrie, Y. (eds) Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. Immunomics Reviews:, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5070-2_7

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