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Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines pp 291–301Cite as

Powder Vaccines for Pulmonary Delivery

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Part of the book series: Immunomics Reviews: ((IMMUN,volume 5))

Abstract

Spray drying represents an elegant one-step process for generating powder products with unique particle characteristics. Respiratory delivery of powder vaccines for the prevention of infectious diseases has shown great promise. Pulmonary delivery using powder vaccine aerosols is an approach to immunization that offers advantages over the use of injection in terms of both delivery technology and vaccine formulation. Powder vaccines for needle-free delivery have been successfully produced during the past decade. The essential elements for the preparation of a powder vaccine through spray drying are reviewed in this chapter. For example, the screening of formulations, the spray dryers from laboratory scale to aseptic manufacturing facilities, and the selection of dry powder inhalers (DPIs) for pulmonary delivery. The advantages and challenges of manufacturing powder vaccines are also discussed.

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References

  1. WHO (2010) Best practices for injections and related procedures toolkit. WHO/EHT/10.02

    Google Scholar 

  2. Garcia-Contreras L, Wong YL et al (2008) Immunization by a bacterial aerosol. Proc Natl Acad Sci U S A 105(12):4656–4660

    Article  PubMed  CAS  Google Scholar 

  3. Ohtake S, Martin RA et al (2010) Heat-stable measles vaccine produced by spray drying. Vaccine 28(5):1275–1284

    Article  PubMed  CAS  Google Scholar 

  4. Jin TH, Tsao E et al (2010) Stabilizing formulations for inhalable powders of an adenovirus 35-vectored tuberculosis (TB) vaccine (AERAS-402). Vaccine 28(27):4369–4375

    Article  PubMed  CAS  Google Scholar 

  5. Bell JH, Hartley PS et al (1971) Dry powder aerosols. I. A new powder inhalation device. J Pharm Sci 60(10):1559–1564

    Article  PubMed  CAS  Google Scholar 

  6. Lin WJ, Griffin DE et al (2011) Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques. Proc Natl Acad Sci U S A 108(7):2987–2992

    Article  PubMed  CAS  Google Scholar 

  7. Amorij JP, Meulenaar J et al (2007) Rational design of an influenza subunit vaccine powder with sugar glass technology: preventing conformational changes of haemagglutinin during freezing and freeze-drying. Vaccine 25(35):6447–6457

    Article  PubMed  CAS  Google Scholar 

  8. Chen D, Dean H et al (2003) Pre-clinical and clinical studies of epidermal powder immunization with an influenza vaccine. Int Congr Ser 1263:555–558

    Article  Google Scholar 

  9. Garmise RJ, Staats HF et al (2007) Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. AAPS PharmSciTech 8(4):2–10

    Article  Google Scholar 

  10. Klas SD, Petrie CR et al (2008) A single immunization with a dry powder anthrax vaccine protects rabbits against lethal aerosol challenge. Vaccine 26(43):5494–5502

    Article  PubMed  CAS  Google Scholar 

  11. Huang J, D’Souza AJ et al (2009) Protective immunity in mice achieved with dry powder formulation and alternative delivery of plage F1-V vaccine. Clin Vaccine Immunol 16(5):719–725

    Article  PubMed  CAS  Google Scholar 

  12. Tim Parsons (2011) Researchers test inhalable measles vaccine. JH Pub Health News. http://www.jhsph.edu/publichealthnews/press_releases/2011/griffin_measles_vaccine.html. Accessed 31 Jan 2011

  13. Maa YF, Nguyen PA et al (1999) Protein inhalation powder: spray drying vs. spray drying. Pharm Res 16(2):249–254

    Article  PubMed  CAS  Google Scholar 

  14. Tzannis ST, Prestrelski SJ (2000) Moisture effects on protein—excipient interactions in spray-dried powders. Nature of destabilizing effects of sucrose. J Pharm Sci 88(3):360–370

    Article  Google Scholar 

  15. Burger JL, Cape SP et al (2008) Stabilizing formulations for inhalable powders of live-attenuated measles virus vaccine. J Aerosol Med Pulm Drug Deliv 21(1):25–34

    Article  PubMed  CAS  Google Scholar 

  16. Corbanie EA, Remon JP et al (2007) Spray drying of an attenuated live Newcastle disease vaccine virus intended for respiratory mass vaccination of poultry. Vaccine 25(49):8306–8317

    Article  PubMed  CAS  Google Scholar 

  17. Broadhead J, Rouan SK et al (1994) The effect of process and formulation variables on the properties of spray-dried beta-galactosidase. J Pharm Pharmacol 46(6):458–467

    Article  PubMed  CAS  Google Scholar 

  18. Labrude P, Rasolomanana M et al (1989) Protective effect of sucrose on spray drying of oxyhemoglobin. J Pharm Sci 78(3):223–239

    Article  PubMed  CAS  Google Scholar 

  19. Bosquillon C, Lombry C et al (2001) Comparison of particle sizing techniques in the case of inhalation dry powders. J Pharm Sci 90(12):2032–2041

    Article  PubMed  CAS  Google Scholar 

  20. Sievers RE, Quinn SP et al (2007) Near-critical fluid micronization of stabilized vaccines, antibiotics and anti-virals. J Supercrit Fluids 42(3):385–391

    Article  CAS  Google Scholar 

  21. Glover W, Chan HK et al (2006) Lung deposition of mannitol powder aerosol in healthy subjects. J Aerosol Med 19(4):522–532

    Article  PubMed  CAS  Google Scholar 

  22. Daviskas E, Anderson SD et al (1997) Inhalation of dry-powder mannitol increases mucociliary clearance. Eur Respir J 10(11):2449–2454

    Article  PubMed  CAS  Google Scholar 

  23. Daviskas E, Anderson SD et al (1999) Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis. Am J Respir Crit Care Med 159(6):1843–1848

    PubMed  CAS  Google Scholar 

  24. Daviskas E, Anderson SD et al (2001) The 24-h Effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest 119(2):414–421

    Article  PubMed  CAS  Google Scholar 

  25. Daviskas E, Anderson SD et al (2005) Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis—effect on lung function. Respirology 10(1):46–56

    Article  PubMed  Google Scholar 

  26. Anderson SD, Brannan J et al (1997) A new method for bronchial provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 156(3):758–765

    PubMed  CAS  Google Scholar 

  27. Imamura K, Iwai M et al (2001) Evaluation of hydration states of protein in freeze-dried amorphous sugar matrix. J Pharm Sci 90(12):1955–1963

    Article  PubMed  CAS  Google Scholar 

  28. Mahlin D, Berggren J et al (2006) The influence of PVP incorporation on moisture-induced surface crystallization of amorphous spray-dried lactose particles. Int J Pharm 321(1–2):78–85

    Article  PubMed  CAS  Google Scholar 

  29. Zhang J, Zografi G (2001) Water vapor absorption into amorphous sucrose-poly(vinyl pyrrolidone) and trehalose-poly(vinyl pyrrolidone) mixtures. J Pharm Sci 90(9):1375–1385

    Article  PubMed  CAS  Google Scholar 

  30. Chen D, Maa YF et al (2002) Needle-free epidermal powder immunization. Expert Rev Vaccines 1(3):265–276

    Article  PubMed  CAS  Google Scholar 

  31. Rochelle C, Lee G (2007) Dextran or hydroxyethyl starch in spray-freeze-dried trehalose/mannitol microparticles intended as ballistic particulate carriers for proteins. J Pharm Sci 96(9):2296–2309

    Article  PubMed  CAS  Google Scholar 

  32. Finlay WH, Lange CF (2000) Lung delivery of aerosolized dextran. Am J Respir Crit Care Med 161(1):91–97

    PubMed  CAS  Google Scholar 

  33. Percy SR (1872) US Patent 125 406

    Google Scholar 

  34. Cryan SA (2005) Carrier-based strategies for targeting protein and peptide drugs to the lungs. AAPS J 7(1):E20–41

    Article  PubMed  CAS  Google Scholar 

  35. Islam N, Gladki E (2008) Dry powder inhalers (DPIs)—a review of device reliability and innovation. Int J Pharm 360(1–2):1–11

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors appreciate Barbara Shepherd for her critical review of the manuscript and thoughtful suggestions. This publication was supported by the Bill & Melinda Gates Foundation.

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Authors and Affiliations

  1. Aeras, Rockville, MD, USA

    Tom Jin & Eric Tsao

Authors
  1. Tom Jin
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  2. Eric Tsao
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Corresponding author

Correspondence to Tom Jin .

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Editors and Affiliations

  1. Aston Pharmacy School, School of Life and Health Sciences, University of Aston, Aston Triangle, Birmingham, B4 7ET, United Kingdom

    Darren R. Flower

  2. Aston Pharmacy School, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom

    Yvonne Perrie

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Jin, T., Tsao, E. (2013). Powder Vaccines for Pulmonary Delivery. In: Flower, D., Perrie, Y. (eds) Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. Immunomics Reviews:, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5070-2_14

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