Natural History of Ulcerative Colitis in Children

Chapter

Abstract

Defining the natural history of a chronic disease is made difficult by the continuously changing landscape of available therapies, earlier recognition of disease by more sensitive diagnostic techniques, and changes in intrinsic biological behavior. The natural history of ulcerative colitis following therapy with aminosalicylates and corticosteroids as were used in the 1960s and 1970s would be expected to differ from that following the current widespread use of immunomodulators and biological therapy. The data presented in this chapter reflect what we know of natural history now, and will likely be different than what we might describe in 10 years. Discussion of drugs will mostly focus mainly on maintenance of remission. Lastly, possible methodology to predict response to therapy and alter natural history will be addressed.

Keywords

Placebo Toxicity Lymphoma Corticosteroid Flare 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Digestive Diseases, Hepatology & NutritionConnecticut Children’s Medical CenterHartfordUSA

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