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Immunizations in the Child with Inflammatory Bowel Disease

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Pediatric Inflammatory Bowel Disease

Abstract

A substantial portion of children and young adults with inflammatory bowel disease (IBD) will be treated with immunosuppressive medications during some course in their disease, placing them at risk for opportunistic infections. Some of these infections may be preventable by vaccinations; therefore, it is important to make sure that patients are up to date with immunizations. Inactivated vaccines can be administered to patients with IBD regardless of immunosuppression status and are generally safe and effective. It is currently recommended not to administer live vaccines to patients with IBD being treated with immunosuppressive therapy, although varicella vaccine has been safely given with good immune response.

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References

  1. Rufo PA, Bousvaros A. Current therapy of inflammatory bowel disease in children. Paediatr Drugs. 2006;8:279–302.

    Article  PubMed  Google Scholar 

  2. Korelitz BI, Fuller SR, Warman JI, Goldberg MD. Shingles during the course of treatment with 6-mercaptopurine for inflammatory bowel disease. Am J Gastroenterol. 1999;94:424–6.

    Article  PubMed  CAS  Google Scholar 

  3. Papadakis KA, Tung JK, Binder SW, et al. Outcome of cytomegalovirus infections in patients with inflammatory bowel disease. Am J Gastroenterol. 2001;96:2137–42.

    Article  PubMed  CAS  Google Scholar 

  4. Wasan SK, Baker SE, Skolnik PR, Farraye FA. A practical guide to vaccinating the inflammatory bowel disease patient. Am J Gastroenterol. 2010;105:1231–8.

    Article  PubMed  Google Scholar 

  5. Sands BE, Cuffari C, Katz J, et al. Guidelines for immunizations in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:677–92.

    Article  PubMed  Google Scholar 

  6. Lu Y, Jacobson D, Bousvaros A. Immunizations in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1417–23.

    Article  PubMed  Google Scholar 

  7. Wasan SK, Coukos JA, Farraye FA. Vaccinating the inflammatory bowel disease patient: deficiencies in gastroenterologists knowledge. Inflamm Bowel Dis. 2011;17:2536–40.

    Article  PubMed  Google Scholar 

  8. Committee on Infectious Diseases. Recommended childhood and adolescent immunization schedules—United States, 2012. Pediatrics. 2012;129:385–6.

    Article  Google Scholar 

  9. Melmed GY, Ippoliti AF, Papadakis KA, et al. Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses. Am J Gastroenterol. 2006;101:1834–40.

    Article  PubMed  Google Scholar 

  10. Crawford NW, Catto-Smith AG, Oliver MR, Cameron DJ, Buttery JP. An Australian audit of vaccination status in children and adolescents with inflammatory bowel disease. BMC Gastroenterol. 2011;11:87.

    Article  PubMed  Google Scholar 

  11. Mamula P, Markowitz JE, Piccoli DA, Klimov A, Cohen L, Baldassano RN. Immune response to influenza vaccine in pediatric patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007;5:851–6.

    Article  PubMed  Google Scholar 

  12. Lu Y, Jacobson DL, Ashworth LA, et al. Immune response to influenza vaccine in children with inflammatory bowel disease. Am J Gastroenterol. 2009;104:444–53.

    Article  PubMed  CAS  Google Scholar 

  13. De Bruyn JC, Hilsden R, Fonseca K, et al. Immunogenicity and safety of influenza vaccination in children with inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:25–33.

    Article  Google Scholar 

  14. Moses J, Alkhouri N, Shannon A, et al. Hepatitis B immunity and response to booster vaccination in children with inflammatory bowel disease treated with infliximab. Am J Gastroenterol. 2012;107:133–8.

    Article  PubMed  CAS  Google Scholar 

  15. Fiorino G, Peyrin-Biroulet L, Naccarato P, et al. Effects of immunosuppression on immune response to pneumococcal vaccine in inflammatory bowel disease: a prospective study. Inflamm Bowel Dis. 2012;18(6):1042–7.

    Article  PubMed  Google Scholar 

  16. Dotan I, Werner L, Vigodman S, et al. Normal response to vaccines in inflammatory bowel disease patients treated with thiopurines. Inflamm Bowel Dis. 2012;18:261–8.

    Article  PubMed  Google Scholar 

  17. Harpaz R, Ortega-Sanchez IR, Seward JF. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2008;57:1–30; quiz CE2–4.

    Google Scholar 

  18. Lu Y, Bousvaros A. Varicella vaccination in children with inflammatory bowel disease receiving immunosuppressive therapy. J Pediatr Gastroenterol Nutr. 2010;50:562–5.

    PubMed  CAS  Google Scholar 

  19. Marin M, Guris D, Chaves SS, Schmid S, Seward JF. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007;56:1–40.

    PubMed  Google Scholar 

  20. Marin M, Meissner HC, Seward JF. Varicella prevention in the United States: a review of successes and challenges. Pediatrics. 2008;122:e744–51.

    Article  PubMed  Google Scholar 

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Disclosures

Research has been funded by Thrasher Research Fund, Merck and Co., Inc., a grant for Training in Pediatric Gastroenterology and Nutrition (T32DK07477), and MO1-RR02172 from the National Center for Research Resources, National Institutes of Health to the Children’s Hospital Boston General Clinical Research Center.

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Correspondence to Athos Bousvaros MD, MPH .

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Bousvaros, A., Lu, Y. (2013). Immunizations in the Child with Inflammatory Bowel Disease. In: Mamula, P., Markowitz, J., Baldassano, R. (eds) Pediatric Inflammatory Bowel Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5061-0_48

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  • DOI: https://doi.org/10.1007/978-1-4614-5061-0_48

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