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Gut Immunity and Inflammatory Bowel Disease

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Pediatric Inflammatory Bowel Disease

Abstract

In-depth understanding of novel immunotherapeutics in inflammatory bowel disease (IBD) requires general familiarity of the intestinal immune system. In this chapter, we discuss fundamentals of intestinal immunity focusing on pathways presumed to be involved in human IBD. We work through fundamentals of adaptive and innate immune responses, drawing where available, specific differences between the developing vs. adult immune system.

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Authors and Affiliations

  1. Department of Internal Medicine, Joint Appointment in Departments of Pediatrics and Immunology, Mayo Clinic, Rochester, MN, USA

    William A. Faubion MD

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  1. William A. Faubion MD
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Correspondence to William A. Faubion MD .

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Editors and Affiliations

  1. Perelman School of Medicine, The Children’s Hospital of Philadelphia, University of Pennsylvania, 34th St. & Civic Ctr. Blvd., Philadelphia, 19104, Pennsylvania, USA

    Petar Mamula

  2. School of Medicine--Greenville, Pediatric Gastroenterology & Nutrition, University of South Carolina, 200 Patewood Drive, Suite A-140, Greenville, 29615, South Carolina, USA

    Jonathan E. Markowitz

  3. Perelman School of Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, 34th St. & Civic Ctr. Blvd., Philadelphia, 19104, Pennsylvania, USA

    Robert N. Baldassano

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Faubion, W.A. (2013). Gut Immunity and Inflammatory Bowel Disease. In: Mamula, P., Markowitz, J., Baldassano, R. (eds) Pediatric Inflammatory Bowel Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5061-0_2

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