Structure and Mechanisms of SF1 DNA Helicases

  • Kevin D. RaneyEmail author
  • Alicia K. Byrd
  • Suja Aarattuthodiyil
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 973)


Superfamily I is a large and diverse group of monomeric and dimeric helicases defined by a set of conserved sequence motifs. Members of this class are involved in essential processes in both DNA and RNA metabolism in all organisms. In addition to conserved amino acid sequences, they also share a common structure containing two RecA-like motifs involved in ATP binding and hydrolysis and nucleic acid binding and unwinding. Unwinding is facilitated by a “pin” structure which serves to split the incoming duplex. This activity has been measured using both ensemble and single-molecule conditions. SF1 helicase activity is modulated through interactions with other proteins.


West Nile Virus Spinal Muscular Atrophy Helicase Activity Helicase Family Helicase Motif 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Funding for this work was provided by NIH R01 GM098922 (K.D.R.).


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Kevin D. Raney
    • 1
    Email author
  • Alicia K. Byrd
    • 1
  • Suja Aarattuthodiyil
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Arkansas for Medical SciencesLittle RockUSA

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