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Systems Medicine: A New Model for Health Care

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Handbook of Systems and Complexity in Health

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Abstract

In 2003, Dr. Elias Zerhouni created the National Institutes of Health (NIH) roadmap and articulated an agenda to aggressively pursue a more integrated approach to use research discoveries to impact human health. Working groups focused on three major themes: New Pathways to Discovery, Research Teams of the Future, and Reengineering the Clinical Research Enterprise. The findings illustrated the need to develop science to decipher biological networks, and the need for broad-scale application of bioinformatics and computational methods to biological systems [1]. In March 2007, the Department of Health and Human Services launched the Personalized Health Care Initiative (PHCI) with the aim to accelerate the development of personalized treatment strategies. The program focuses on high-throughput technologies and developing an infrastructure to promote electronic medical records [2].

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Notes

  1. 1.

    Exomes are the protein coding regions of DNA which constitute about 1% of the whole genome. Exome sequencing is used to identify variants found in the coding region of genes which affect protein function. It does not identify structural or regulatory variants associated with diseases in non-coding DNA, which can be identified by whole genome sequencing (WGS).

  2. 2.

    http://www.broadinstitute.org/cmap/

  3. 3.

    http://www.The-dream-project.org/

  4. 4.

    http://www.cloudgalaxy.com

  5. 5.

    http://www.ncbi.nlm.nih.gov

  6. 6.

    http://www.hgvs.org

  7. 7.

    http://www.humanvariomeproject.org

  8. 8.

    https://www.I2b2.org

  9. 9.

    http://www.pentaho.com

  10. 10.

    http://www.ukbiobank.ac.uk

  11. 11.

    http://www.cancer.org/Research

  12. 12.

    http://www.rpgeh.kaiser.org

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Acknowledgements

The authors are grateful to Dr Edmund Pellegrino for his comments on the manuscript. The authors recognize support from grant W81XWH-09-1-0107 from the Telemedicine and Advanced Technology Research Center, USAMRMC.

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Authors and Affiliations

  1. The Georgetown University Medical Center, Washington, DC, USA

    Linda MacArthur PhD, Timothy R. Mhyre PhD, Sona Vasudevan PhD, Elliott Crooke PhD & Howard J. Federoff MD, PhD

  2. O’Neill Institute for National and Global Health Law, Georgetown University, Washington, DC, USA

    Elenora Connors JD, MPH

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  1. Linda MacArthur PhD
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  2. Timothy R. Mhyre PhD
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  3. Elenora Connors JD, MPH
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  4. Sona Vasudevan PhD
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  5. Elliott Crooke PhD
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  6. Howard J. Federoff MD, PhD
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Correspondence to Howard J. Federoff MD, PhD .

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    Joachim P. Sturmberg

  2. Northern Ontario School of Medicine, Merchandise Mart Plaza, Suite 1212 222, Chicago, 60654, Illinois, USA

    Carmel M. Martin

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MacArthur, L., Mhyre, T.R., Connors, E., Vasudevan, S., Crooke, E., Federoff, H.J. (2013). Systems Medicine: A New Model for Health Care. In: Sturmberg, J., Martin, C. (eds) Handbook of Systems and Complexity in Health. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4998-0_51

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