Intravoxel Incoherent Motion MR Imaging of the Kidney: Pilot Study

  • Per Eckerbom
  • Peter Hansell
  • Tomas Bjerner
  • Fredrik Palm
  • Jan Weis
  • Per Liss
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 765)

Abstract

MR examinations (Achieva 3 T, Philips, Best, The Netherlands) were performed at five different occasions in a healthy volunteer (male 60 years) and in one renal cancer patient (male 78 years) with normal renal function (creatinine 88 μmol/L). Intravoxel incoherent motion (IVIM) coefficients D + D* were measured using respiratory-triggered diffusion-weighted spin-echo echo-planar imaging. Perfusion data of the patient were acquired using a saturation-recovery gradient-echo sequence and with the bolus of Gd-BOPTA (Multihance). D + D* were computed by monoexponential fitting of MR signal intensity attenuation versus b for b = 0, 50, 100, 150 s/mm2. Perfusion parameters were evaluated with “NordicICE” software. The map of D + D* was compared qualitatively with the perfusion map computed from the Gd scan. D + D* values of the cortex and medulla were in the range 2.3–2.7 and 1.1–1.6 × 10-3 mm2/s, respectively. In conclusion, in this pilot study a good qualitative relation between IVIM variables D + D* and renal perfusion has been found.

Keywords

Magnetic resonance Kidney Blood flow 

Notes

Acknowledgments

The work was supported by the Swedish Society for Medical Research, the Swedish Diabetes Foundation, and the Swedish Research Council.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Per Eckerbom
    • 1
  • Peter Hansell
    • 2
  • Tomas Bjerner
    • 1
  • Fredrik Palm
    • 2
  • Jan Weis
    • 1
  • Per Liss
    • 1
  1. 1.Department of Radiology, Center for Medical ImagingUppsala University Hospital, Uppsala UniversityUppsalaSweden
  2. 2.Department of Medical Cell BiologyUppsala UniversityUppsalaSweden

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