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The Effect of Venous and Arterial Occlusion of the Arm on Changes in Tissue Hemodynamics, Oxygenation, and Ultra-Weak Photon Emission

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Oxygen Transport to Tissue XXXIV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 765))

Abstract

Ultra-weak photon emission (UPE) is a general feature of living ­biological systems. To gain further insights into the origin of UPE and its physiological significance, the aim of the present study was to investigate the connection between hemodynamics (HD), oxygenation (OX), and UPE. Therefore, during venous and arterial occlusion (VO, AO), changes of UPE and surrogates of HD as well as OX were measured simultaneously using two photomultipliers and near-infrared spectroscopy, respectively. We showed that (1) changes in UPE correlate significantly nonlinearly with changes in oxyhemoglobin (Δ[O2Hb]), deoxyhemoglobin (Δ[HHb]), and hemoglobin difference (Δ[HbD] = Δ[O2Hb]−Δ[HHb]), indicating a complex association between UPE and tissue HD/OX; (2) UPE decreases significantly during AO but not during VO; (3) UPE increases significantly after AO; and (4) the view that ROS are the source of UPE is generally supported by the present study, although some findings remain unexplained in the context of the theory of ROS-mediated UPE generation. In conclusion, the present study revealed new insights into the interplay between HD, OX, and UPE and opens up new questions that have to be addressed by future studies.

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Acknowledgments

The authors thank Raphael Zimmerman and Andreas Metz for hardware and software support concerning the NIRS measurements, Rachel Folkes for proofreading the manuscript, as well as Dr. Lisa Holper, Dr. Daniel Fels, Dr. Michal Cifra, and Reto Kofmehl for stimulating discussions.

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Authors and Affiliations

  1. Division of Neonatology, Biomedical Optics Research Laboratory, University Hospital Zurich, Frauenklinikstr. 10, 8091, Zurich, Switzerland

    Felix Scholkmann & Martin Wolf

  2. Meluna Research, 3821 AE, Amersfoort, The Netherlands

    Olaf Schraa & Roeland van Wijk

Authors
  1. Felix Scholkmann
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  2. Olaf Schraa
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  3. Roeland van Wijk
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  4. Martin Wolf
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Corresponding author

Correspondence to Felix Scholkmann .

Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA

    William J. Welch

  2. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

    Fredrik Palm

  3. Synthesizer, Inc., Ellicott City, MD, USA

    Duane F. Bruley

  4. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

    David K. Harrison

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Scholkmann, F., Schraa, O., van Wijk, R., Wolf, M. (2013). The Effect of Venous and Arterial Occlusion of the Arm on Changes in Tissue Hemodynamics, Oxygenation, and Ultra-Weak Photon Emission. In: Welch, W.J., Palm, F., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXIV. Advances in Experimental Medicine and Biology, vol 765. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4989-8_36

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