Wavelet Cross-Correlation to Investigate Regional Variations in Cerebral Oxygenation in Infants Supported on Extracorporeal Membrane Oxygenation

  • Maria Papademetriou
  • Ilias Tachtsidis
  • Martin J. Elliott
  • Aparna Hoskote
  • Clare E. Elwell
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 765)

Abstract

Extracorporeal membrane oxygenation can potentially affect cerebral blood flow dynamics and consequently influence cerebral autoregulation. We applied wavelet cross-correlation (WCC) between multichannel cerebral oxyhemoglobin concentration (HbO2) and mean arterial pressure (MAP), to assess regional variations in cerebral autoregulation. Six infants on veno-arterial (VA) ECMO were studied during sequential changes in the ECMO flows. WCC between MAP and HbO2 for each flow period and each channel was calculated within three different frequency (wavelet scale) bands centered around 0.1, 0.16, and 0.3 Hz chosen to represent low frequency oscillations, ventilation, and respiration rates, respectively. The group data showed a relationship between maximum WCC and ECMO flow. During changes in ECMO flow, statistically significant differences in maximum WCC were found between right and left hemispheres. WCC between HbO2 and MAP provides a useful method to investigate the dynamics of cerebral autoregulation during ECMO. Manipulations of ECMO flows are associated with regional changes in cerebral autoregulation which may potentially have an important bearing on clinical outcome.

Keywords

Cerebral oxygenation Infants 

Notes

Acknowledgment

This work was supported by Hitachi Medical Ltd., Japan.

References

  1. 1.
    Bulas D, Glass P (2005) Neonatal ECMO: neuroimaging and neurodevelopmental outcome. Semin Perinatol 29:58–65CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Liem D, Hopman J, Oeseburg B, de Haan A, Festen C, Kollee L (1995) Cerebral oxygenation and hemodynamics during induction of extracorporeal membrane oxygenation as investigated by near infrared spectrophotometry. Pediatrics 95:555–561PubMedPubMedCentralGoogle Scholar
  3. 3.
    Czosnyka M, Brady K, Reinhard M, Smielewski P, Steiner L (2009) Monitoring cerebrovascular autoregulation: facts, myths and missing links. Neurocrit Care 10:373–86CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Panerai RB, Moody M, Eames PJ, Potter JF (2005) Cerebral blood flow velocity during mental activation: interpretation with different models of the passive pressure–velocity relationship. J Appl Physiol 99:2352–2362CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Latka M, Turalska M, Latka MG, Kolodziej W, Latka D, West BJ (2005) Phase dynamics in cerebral autoregulation. Am J Heart Circ Physiol 289:H2272–H2279CrossRefGoogle Scholar
  6. 6.
    Rowley AB, Payne SJ, Tachtsidis I, Ebden MJ, Whiteley JP, Gavaghan DJ, Smith M, Elwell CE, Delpy DT (2007) Synchronisation between arterial blood pressure and cerebral concentration investigated by wavelet cross-correlation. Physiol Meas 28:161–173CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Papademetriou MD, Tachtsidis I, Leung TS, Elliott MJ, Hoskote A, Elwell CE (2010) Cerebral and peripheral tissue oxygenation in infants and children supported on ECMO for cardio-respiratory failure. Adv Exp Med Biol 662:447–453CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Papademetriou MD, Tachtsidis I, Leung TS, Elliott MJ, Hoskote A, Elwell CE (2011) Regional cerebral oxygenation measured by multichannel near-infrared spectroscopy (optical topography) in an infant supported on venoarterial extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg 141:e31–e33CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© The Author(s) 2013

Authors and Affiliations

  • Maria Papademetriou
    • 1
  • Ilias Tachtsidis
    • 1
  • Martin J. Elliott
    • 2
  • Aparna Hoskote
    • 2
  • Clare E. Elwell
    • 1
  1. 1.Medical Physics and Bioengineering DepartmentUniversity College LondonLondonUK
  2. 2.Cardiothoracic UnitGreat Ormond Street Hospital for ChildrenLondonUK

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