Skip to main content
SpringerLink
Log in

Toward the Metabolomics of Jatropha curcas

  • Chapter
  • First Online:
Jatropha, Challenges for a New Energy Crop

Abstract

Jatropha curcas is a bush with a long history of use in popular medicine, lamp oil and soap production. The more recently developed interest in biodiesel has boosted the scientific interest, because of the high yield of oil in its seeds. But the toxicity of these seeds has being hindering their large scale use for animal feeding. In the past years, several methods to handle the toxicity have been presented, in order to improve the exploitation of the crop. Understanding the metabolomics of J. curcas could improve its overall utilization.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adam SEI (1974) Toxic effects of Jatropha curcas in mice. Toxicology 2(1):67–76

    Article  CAS  PubMed  Google Scholar 

  • Adam SEI, Magzoub M (1975) Toxicity of Jatropha curcas for goats. Toxicology 4(3):347–354

    Article  CAS  PubMed  Google Scholar 

  • Adolf W, Opferkuch H, Hecker E (1984) Irritant phorbol derivatives from four Jatropha species. Phytochemistry 23(1):129–132

    Article  CAS  Google Scholar 

  • Ahmad MU, Islam MR, Mirza AH, Chowdhury BH, Nahar N (1992) Alkaloids of Jatropha gossypiifolia Linn. Indian J Chem Sect B 31(1):67–69

    Google Scholar 

  • Ahmed OMM, Adam SEI (1979a) Effects of Jatropha curcas on calves. Vet Pathol 16(4):476–482

    CAS  PubMed  Google Scholar 

  • Ahmed OMM, Adam SEI (1979b) Toxicity of Jatropha curcas in sheep and goats. Res Vet Sci 27(1):89–96

    CAS  PubMed  Google Scholar 

  • Aiyelaagbe OO (2001) Antibacterial activity of Jatropha multifida roots. Fitoterapia 72(5):544–546

    Article  CAS  PubMed  Google Scholar 

  • Aiyelaagbe OO, Gloer JB (2008) Japodic acid, a novel aliphatic acid from Jatropha podagrica Hook. Rec Natl Prod 2(4):100–106

    CAS  Google Scholar 

  • Aiyelaagbe OO, Oguntuase B (2008) The antimicrobial activity of Jatropha multifida extracts and chromatographic fractions against sexually transmitted infections. J Med Sci 8:143–147. doi:10.3923/jms.2008.143.147

    Article  Google Scholar 

  • Alyelaagbe OO, Adesogan K, Ekundayo O, Gloer JB (2007) Antibacterial diterpenoids from Jatropha podagrica Hook. Phytochemistry 68(19):2420–2425

    Article  CAS  Google Scholar 

  • Aregheore EM, Makkar HPS, Becker K (1998) Assessment of lectin activity in a toxic and a non-toxic variety of Jatropha curcas using latex agglutination and haemagglutination methods and inactivation of lectin by heat treatments. J Sci Food Agric 77(3):349–352

    Article  CAS  Google Scholar 

  • Asase A, Oteng-Yeboah AA, Odamtten GT, Simmonds MSJ (2005) Ethnobotanical study of some Ghanaian anti-malarial plants. J Ethnopharmacol 99(2):273–279

    Article  PubMed  Google Scholar 

  • Auvin C, Baraguey C, Blond A, Lezenven F, Pousset JL, Bodo B, Curcacycline B (1997) A cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin. Tetrahedron Lett 38(16):2845–2848

    Article  CAS  Google Scholar 

  • Auvin-Guette C, Baraguey C, Blond A, Pousset JL, Bodo B, Cyclogossine B (1997) A cyclic octapeptide from Jatropha gossypiifolia. J Nat Prod 60(11):1155–1157

    Article  CAS  Google Scholar 

  • Auvin-Guette C, Baraguey C, Blond A, Xavier HS, Pousset JL, Bodo B (1999) Pohlianins A, B and C, cyclic peptides from the laxes of Jatropha pohliana ssp. molissima. Tetrahedron 55(38):11495–11510

    Article  CAS  Google Scholar 

  • Bais P, Moon SM, He K, Leitao R, Dreher K, Walk T et al (2010) PlantMetabolomics.org: a web portal for plant metabolomics experiments. Plant Physiol 152(4):1807–1816

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baleé W (1994) Footprints of forest, Ka’apor ethnobotany-the historical ecology of plant utilization by an Amazonian people. Columbia University Press, New York

    Google Scholar 

  • Bamidele Sanni S, Behm H, Beurskens PT, Kayode Adesogan E, Durodola JI (1988) Crystal and molecular structure of 1R,3 S,5S,7R,10R-3,6,6,10,14Pentamethyltricyclo[10.3.0.05,7]pentadeca-11,14-diene-1, 10-dihydroxy-2,13-dione (Japodagrol), C20H28O4. J Crystallogr Spectro Res 18(5):575–582

    Article  Google Scholar 

  • Banerji J, Das B, Chatterjee A, Shoolery JN (1984) Gadain, a lignan from Jatropha gossypiifolia. Phytochemistry 23(10):2323–2327

    Article  CAS  Google Scholar 

  • Banerji J, Das B, Bose P, Chakabarti R (1993) Traditional medicine. Oxford and IBH, New Delhi

    Google Scholar 

  • Baraguey C, Auvin-Guette C, Blond A, Cavelier F, Lezenven F, Pousset JL et al (1998) Isolation, structure and synthesis of chevalierins A, B and C, cyclic peptides from the latex of Jatropha chevalieri. J Chem Soc Perk T 18:3033–3039. doi:10.1039/A804003F

    Article  Google Scholar 

  • Baraguey C, Blond A, Correia I, Pousset JL, Bodo B, Auvin-Guette C, Mahafacyclin A (2000) A cyclic heptapeptide from Jatropha mahafalensis exhibiting beta-bulge conformation. Tetrahedron Lett 41(3):325–329

    Article  CAS  Google Scholar 

  • Baraguey C, Blond A, Cavelier F, Pousset JL, Bodo B, Auvin-Guette C (2001) Isolation, structure and synthesis of mahafacyclin B, a cyclic heptapeptide from the latex of Jatropha mahafalensis. J Chem Soc Perk T 1 17:2098–2103

    Article  CAS  Google Scholar 

  • Barbosa SC, Cilli EM, Dias LG, Stabeli RG, Ciancaglini P (2011) Labaditin, a cyclic peptide with rich biotechnological potential: preliminary toxicological studies and structural changes in water and lipid membrane environment. Amino Acids 40(1):135–144

    Article  CAS  PubMed  Google Scholar 

  • Becker K, Makkar HPS (2008) Jatropha curcas: a potential source for tomorrow’s oil and biodiesel. Lipid Technol 20(5):104–107

    Article  CAS  Google Scholar 

  • Beukelman C, Leeflang BR, Labadie RP (1995) Curcacycline A–a novel cyclic octapeptide isolated from the latex of Jatropha curcas L. FEBS Lett 358(3):215–218

    Article  PubMed  Google Scholar 

  • Bhattacharyya J, Barros CB (1986) Triterpenoids of Cnidosculus urens. Phytochemistry 25(1):274–276

    Article  CAS  Google Scholar 

  • Brum R, Honda N, Mazarin S, Hess S, Cavalheiro A, Delle Monache F (1998) Jatrowedione, a lathyrane diterpene from Jatropha weddelliana. Phytochemistry 48(7):1225–1227

    Article  CAS  Google Scholar 

  • Brum R, Cavalheiro A, Monache F, Vencato I (2001) Jatrowediol, a lathyrane diterpene from Jatropha weddelliana. J Brazil Chem Soc 12(2):259–262

    Article  CAS  Google Scholar 

  • Burkill HM, Dalziel JM (1997) The useful plants of west Tropical Africa, vol 4, 2nd edn, The useful plants of west Tropical Africa: families M-R. Royal Botanic Gardens, Kew

    Google Scholar 

  • Calixto JB, Sant’Ana AEG (1987) Pharmacological analysis of the inhibitory effect of jatrophone, a diterpene isolated from Jatropha elliptica, on smooth and cardiac muscles. Phytother Res 1(3):122–126

    Article  CAS  Google Scholar 

  • Calixto JB, Sant’Ana AEG (1990) Evidence for the mechanism of the inhibitory action of jatrophone in the isolated rat uterine muscle. Gen Pharmacol 21(1):117–122

    Article  CAS  PubMed  Google Scholar 

  • Cantrell C, Ali A, Duke S (2011) Identification of mosquito biting deterrent constituents from the Indian folk remedy plant Jatropha curcas. J Med Entomol 48(4):836–845

    Article  CAS  PubMed  Google Scholar 

  • Carmelo R (1979) Components from the latex of Jatropha acotinifolia Mill. var. palmata (Wild) Muell. Arg. Rev Latinoam Quim 10(1):35–36

    Google Scholar 

  • Ceasar SA, Ignacimuthu S (2011) Applications of biotechnology and biochemical engineering for the improvement of Jatropha and biodiesel: a review. Renew Sust Energ Rev 15(9):5176–5185

    Article  CAS  Google Scholar 

  • Chan-Bacab MJ, Peña-Rodríguez LM (2001) Plant natural products with leishmanicidal activity. Nat Prod Rep 18(6):674–688

    Article  CAS  PubMed  Google Scholar 

  • Chatterjee A, Das B, Chakrabarti R, Bose P, Banerji J, Banerji A et al (1988) Prasanthaline -a new lignan from Jatropha gossypiifolia Linn. Indian J Chem B 27(8):740–741

    Google Scholar 

  • Coelho SM, Peters AF, Charrier B, Roze D, Destombe C, Valero M et al (2007) Complex life cycles of multicellular eukaryotes: new approaches based on the use of model organisms. Gene 406(1–2):152–170

    Article  CAS  PubMed  Google Scholar 

  • Corvera S, García-Sáinz JA (1984) Phorbol esters inhibit alpha 1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes. Biochem Biophys Res Commun 119(3):1128–1133

    Article  CAS  PubMed  Google Scholar 

  • D’Alagni M, De Petris M, Marini-Bettolo GB, Temussi PA (1983) Study of the binding of jatrophone to Escherichia coli s-ribonucleic acid. FEBS Lett 164(1):51–56

    Article  PubMed  Google Scholar 

  • Dabur R, Gupta A, Mandal TK, Singh DD, Bajpai V, Gurav AM et al (2007) Antimicrobial activity of some Indian medicinal plants. Afr J Tradit Complement Altern Med 4(3):313–318

    PubMed  PubMed Central  Google Scholar 

  • Dahiya R (2008) Synthesis and in vitro cytotoxic activity of a natural peptide of plant origin. J Iran Chem Soc 5(3):445–452

    Article  CAS  Google Scholar 

  • Dai XZ, Bache RJ (1985) Coronary and systemic hemodynamic effects of tetramethylpyrazine in the dog. J Cardiovasc Pharmacol 7(5):841–849

    Article  CAS  PubMed  Google Scholar 

  • Das B, Kashinatham A, Das R (1998) Gossypiline, a new lignan from Jatropha gossypiifolia. Nat Prod Sci 4(4):238–240

    CAS  Google Scholar 

  • Das B, Anjani G (1999) Gossypidien, a lignan from stems of Jatropha gossypiifolia. Phytochemistry 51:115–117

    Article  CAS  Google Scholar 

  • Das B, Banerji J (1988) Arylnaphthalene lignan from Jatropha gossypiifolia. Phytochemistry 27(11):3684–3686

    Article  CAS  Google Scholar 

  • Das B, Das R (1995) Gossypifan, a lignan from Jatropha gossypiifolia. Phytochemistry 40(3):931–932

    Article  CAS  Google Scholar 

  • Das B, Kashinatham A (1997) Studies on phytochemicals: part XVII -Phenolics from the roots of Jatropha gossypiifolia. Indian J Chem B 36(11):1077–1078

    Google Scholar 

  • Das B, Venkataiah B (1999) A rare diterpene from Jatropha gossypiifolia. Biochem Syst Ecol 27(7):759–760

    Article  CAS  Google Scholar 

  • Das B, Venkataiah B (2001) A minor coumarino-lignoid from Jatropha gossypiifolia. Biochem Syst Ecol 29(2):213–214

    Article  CAS  PubMed  Google Scholar 

  • Das B, Rao SP, Srinivas KVNS (1996a) Isolation of isogadain from Jatropha gossypiifolia. Planta Med 62(1):90

    Article  CAS  PubMed  Google Scholar 

  • Das B, Rao SP, Srinivas KVNS (1996b) Jatrodien, a lignan from stems of Jatropha gossypiifolia. Phytochemistry 41(3):985–987

    Article  CAS  Google Scholar 

  • Das B, Venkataiah B, Kashinatham A (1999) Venkatasin, a new coumarino-lignoid from Jatropha gossypiifolia. Nat Prod Lett 13(4):293–297

    Article  CAS  Google Scholar 

  • Das B, Kashinatham A, Venkataiah B, Srinivas KVNS, Mahender G, Reddy M, (2003a) Cleomiscosin A, a coumarino-lignoid from Jatropha gossypiifolia. Biochem Syst Ecol 31(10):1189–1191

    Article  CAS  Google Scholar 

  • Das R, Srinivas KVNS, Ramu IR, Venkataiah B, Das B (2003b) New propacin analogs from a collection of the whole plant of Jatropha gossypiifolia. Int J Chem Sci 1:159

    CAS  Google Scholar 

  • Das B, Reddy MR, Ravindranath N, Kishore KH, Murthy USN (2005) Studies on phytochemicals. Part 48. A substituted imidazole derivative from Jatropha curcas. ChemInform 36(39). doi:10.1002/chin.200539182

    Google Scholar 

  • Das B, Ravikanth B, Reddy KR, Thirupathi P, Raju TV, Sridhar B (2008) Diterpenoids from Jatropha multifida. Phytochemistry 69(14):2639–2641

    Article  CAS  PubMed  Google Scholar 

  • Das B, Laxminarayana K, Krishnaiah M, Srinivas Y, Raju TV (2009a) Multidione, a novel diterpenoid from Jatropha multifida. Tetrahedron Lett 50(34):4885–4887

    Article  CAS  Google Scholar 

  • Das B, Ravikanth B, Laxminarayana K, Ramarao B, Raju TV (2009b) New macrocyclic diterpenoids from Jatropha multifida. Chem Pharm Bull 57(3):318–320

    Article  CAS  PubMed  Google Scholar 

  • Das B, Reddy KR, Ravikanth B, Raju TV, Sridhar B, Khan PU et al (2009c) Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida. Bioorg Med Chem Lett 19:77–79

    Article  CAS  PubMed  Google Scholar 

  • Das B, Satya Kumar A, Narayan Kumar J, Venugopal Raju T (2010) A new macrocyclic diterpenoid from Jatropha multifida. Nat Prod Res 24(16):1510–1513

    Article  CAS  PubMed  Google Scholar 

  • Das M, Uppal HS, Singh R, Beri S, Mohan KS, Gupta VC, Adholeya A (2011) Co-composting of physic nut (Jatropha curcas) deoiled cake with rice straw and different animal dung. Bioresour Technol 102(11):6541–6546

    Article  CAS  PubMed  Google Scholar 

  • de Lemos T, Silveira E, Oliveira M (1991) Terpenoids from Cnidoscolus phyllacanthus Pax et Hoff. J Brazil Chem Soc 2:105–110

    Article  Google Scholar 

  • de Lima MRF, de Souza LJ, dos Santos AF, de Andrade MCC, Sant’Ana AEG, Genet JP et al (2006) Anti-bacterial activity of some Brazilian medicinal plants. J Ethnopharmacol 105(1–2):137–147

    Article  PubMed  Google Scholar 

  • de Moraes VL, Rumjanek VM, Calixto JB (1996) Jatrophone and 12-O-tetradecanoyl phorbol-13-acetate antagonism of stimulation of natural killer activity and lymphocyte proliferation. Eur J Pharmacol 312(3):333–339

    Article  PubMed  Google Scholar 

  • Debnath M, Pandey M, Bisen PS (2011) An omics approach to understand the plant abiotic stress. OMICS 15(11):739–762

    Article  CAS  PubMed  Google Scholar 

  • Dekker TG, Fourie TG, Matthee E, Snyckers FO, Ammann W (1987) Studies of South-African medicinal-plants. 4. Jaherin, a new daphnane diterpene with antimicrobial properties from Jatropha zeyheri. S Afr J Chem 40(1):74–76

    CAS  Google Scholar 

  • Denton RW, Harding WW, Anderson CI, Jacobs H, McLean S, Reynolds WF (2001) New diterpenes from Jatropha divaricata. J Nat Prod 64(6):829–831

    Article  CAS  PubMed  Google Scholar 

  • Devappa RK, Makkar HPS, Becker K (2010a) Jatropha diterpenes: a review. J Am Oil Chem Soc 88(3):301–322

    Article  CAS  Google Scholar 

  • Devappa RK, Makkar HPS, Becker K (2010b) Jatropha toxicity – a review. J Toxicol Environ Health Part B 13(6):476–507

    Article  CAS  Google Scholar 

  • Devappa RK, Makkar HPS, Becker K (2010c) Nutritional, biochemical, and pharmaceutical potential of proteins and peptides from Jatropha: review. J Agric Food Chem 58(11):6543–6555

    Article  CAS  PubMed  Google Scholar 

  • Devappa RK, Angulo-Escalante MA, Makkar HPS, Becker K (2012) Potential of using phorbol esters as an insecticide against Spodoptera frugiperda. Ind Crops Prod 38:50–53

    Article  CAS  Google Scholar 

  • dos Santos AF, Sant’Ana AEG (1999) Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated from Jatropha elliptica (Pohl) Muell. Arg. Phytother Res 13(8):660–664

    Article  PubMed  Google Scholar 

  • Duke JA (1985) Medicinal plants. Science 229(4718):1036–1038

    Article  CAS  PubMed  Google Scholar 

  • El Badwi SM, Mousa HM, Adam SEI, Hapke HJ (1992) Response of brown hisex chicks to low levels of Jatropha curcas, Ricinus communis or their mixture. Vet Hum Toxicol 34(4):304–306

    CAS  PubMed  Google Scholar 

  • Endo Y, Ohta T, Nozoe S (1991) Favelanone, a novel tetracyclic cyclopropane derivative from the Brazilian plant, Cnidoscolus phyllacanthus. Tetrahedron Lett 32(40):5555–5558

    Article  CAS  Google Scholar 

  • Esimone CO, Nworu CS, Jackson CL (2008) Cutaneous wound healing activity of a herbal ointment containing the leaf extract of Jatropha curcas L. (Euphorbiaceae). IJARNP 1(4):1–4

    Google Scholar 

  • Foidl N, Eder P (1997) Agro-industrial exploitation of J. curcas. In: Gübitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 88–91

    Google Scholar 

  • Foidl N, Foidl G, Sanchez M, Mittelbach M, Hackel S (1996) Jatropha curcas L. as a source for the production of biofuel in Nicaragua. Bioresour Technol 58(1):77–82

    Article  CAS  Google Scholar 

  • Franke K, Nasher A, Schmidt J (2004) Constituents of Jatropha unicostata. Biochem Syst Ecol 32(2):219–220

    Article  CAS  Google Scholar 

  • Gandhi VM, Cherian KM, Mulky MJ (1995) Toxicological studies on ratanjyot oil. Food Chem Toxicol 33(1):39–42

    Article  CAS  PubMed  Google Scholar 

  • García A, Delgado G (2006) Cytotoxic cis-fused bicyclic sesquiterpenoids from Jatropha neopauciflora. J Nat Prod 69(11):1618–1621

    Article  PubMed  CAS  Google Scholar 

  • Goonasekera MM, Gunawardana VK, Jayasena K, Mohammed SG, Balasubramaniam S (1995) Pregnancy terminating effect of Jatropha curcas in rats. J Ethnopharmacol 47(3):117–123

    Article  CAS  PubMed  Google Scholar 

  • Gübitz GM, Mittelbach M, Trabi M (1999) Exploitation of the tropical oil seed plant Jatropha curcas L. Bioresour Technol 67(1):73–82

    Article  Google Scholar 

  • Haas W, Mittelbach M (2000) Detoxification experiments with the seed oil from Jatropha curcas L. Ind Crops Prod 12(2):111–118

    Article  CAS  Google Scholar 

  • Haas W, Sterk H, Mittelbach M (2002) Novel 12-deoxy-16-hydroxyphorbol diesters isolated from the seed oil of Jatropha curcas. J Nat Prod 65(10):1434–1440

    Article  CAS  PubMed  Google Scholar 

  • Hart LT, Van Dijk H, Labadie RP (1989) Inhibitory activity of Jatropha multifida latex on classical complement pathway activity in human serum mediated by a calcium-binding proanthocyanidin. J Ethnopharmacol 27:81–89

    Article  PubMed  Google Scholar 

  • Hirai MY, Sawada Y, Kanaya S, Kuromori T, Kobayashi M, Klausnitzer R et al (2010) Toward genome-wide metabolotyping and elucidation of metabolic system: metabolic profiling of large-scale bioresources. J Plant Res 123(3):291–298

    Article  CAS  PubMed  Google Scholar 

  • Horsten SF, van den Berg AJ, Kettenes-van den Bosch JJ, Leeflang BR, Labadie RP (1996) Cyclogossine A: a novel cyclic heptapeptide isolated from the latex of Jatropha gossypiifolia. Planta Med 62(1):46–50

    Article  CAS  PubMed  Google Scholar 

  • Ishii Y, Takeuchi R, Tokida K (1987) Transesterified curcas oil as a farm diesel engine fuel. In: Proceedings of the international symposium on agricultural mechanization and international cooperation in high technology era. Tokyo, pp 239–246

    Google Scholar 

  • Jakupovic J, Grenz M, Schmeda-Hirschmann G (1988) Rhamnofolane derivatives from Jatropha grossidentata. Phytochemistry 27(9):2997–2998

    Article  CAS  Google Scholar 

  • Jing L, Fang Y, Ying X, Wenxing H et al (2005) Toxic impact of ingested Jatropherol-l on selected enzymatic activities and the ultrastructure of midgut cells in silkworm, Bombyx mori L. J Appl Entomol 129(2):98–104

    Article  CAS  Google Scholar 

  • Jones N, Miller J (1992) Jatropha curcas: a multipurpose species for problematic sites. Land Resour Ser 1:40

    Google Scholar 

  • Joshi C, Mathur P, Khare SK (2011) Degradation of phorbol esters by Pseudomonas aeruginosa PseA during solid-state fermentation of deoiled Jatropha curcas seed cake. Bioresour Technol 102(7):4815–4819

    Article  CAS  PubMed  Google Scholar 

  • Kakade A, Pawar M, Wadkar K, Patil S, Magdum CS, Naikwade NS (2008) A comprehensive review of Jatropha gossypiifolia Linn. Pharmacog Rev 2(4 suppl):2–6

    CAS  Google Scholar 

  • Kanth BS, Kumar AS, Shinde DB, Babu KH, Raju TV, Kumar CG et al (2011) New bioactive macrocyclic diterpenoids from Jatropha multifida. Bioorg Med Chem Lett 21:6808–6810

    Article  CAS  PubMed  Google Scholar 

  • Kaou AM, Mahiou-Leddet V, Hutter S, Aïnouddine S, Hassani S, Yahaya I et al (2008) Antimalarial activity of crude extracts from nine African medicinal plants. J Ethnopharmacol 116(1):74–83

    Article  PubMed  Google Scholar 

  • Kayode J (2008) Checklist and status of plant species used as spices in Kaduna State of Nigeria. Res J Bot 3(1):35–40

    Article  Google Scholar 

  • Khafagy SM, Mohamed YA, Abdel Salam NA, Mahmoud ZF (1977) Phytochemical study of Jatropha curcas. Planta Med 31(3):273–277

    Article  CAS  PubMed  Google Scholar 

  • Kirtikar KR, Das Basu B (1918) Indian medical plants. Sudhindra Nath Basu, Allahabad

    Google Scholar 

  • Kong LY, Jin DZ, Min ZD (1993) The diterpenoids from Jatropha curcas. World Phytomed 8(6):243–245

    Google Scholar 

  • Kong LY, Min ZD, Shi J, Feng R (1996) Chemical constituents from roots of Jatropha curcas. Acta Bot Sin 38:2

    Google Scholar 

  • Kosasi S, Van der Sluis WG, Boelens R, Hart LT, Labadie RP (1989) Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida L. (Euphorbiaceae). FEBS Lett 256(1–2):91–96

    Article  CAS  Google Scholar 

  • Kroes B, Leeflang BR, Labadie RP (1996) Podacycline A and B, two cyclic peptides in the latex of Jatropha podagrica. Phytochemistry 42(1):129–133

    Article  PubMed  Google Scholar 

  • Kumar A, Sharma S (2008) An evaluation of multipurpose oil seed crop for industrial uses (Jatropha curcas L.): a review. Ind Crops Prod 28(1):1–10

    Article  CAS  Google Scholar 

  • Kupchan SM, Sigel CW, Matz MJ, Renauld JAS, Haltiwan RC, Bryan RF (1970) Jatrophone, a novel macrocyclic diterpenoid tumor Inhibitor from Jatropha gossypiifolia. J Am Chem Soc 92(14):4476–4478

    Article  CAS  Google Scholar 

  • Laibach F (1943) Arabidopsis thaliana (L.) Heynh. als Objekt für genetische und entwicklungsphysiologische Untersuchungen. In: Mez C (ed) Botanisches Archiv: Zeitschrift für die gesamte Botanik. Verlag des Repertoriums, Berlin-Dahlem, pp 439–455, German

    Google Scholar 

  • Lakshmi M, Venkata R (1975) Occurrence of vitexin in J. heterophylla. Curr Sci 44(19):721

    CAS  Google Scholar 

  • Lans C (2007) Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. J Ethnobiol Ethnomed 3:3

    Article  PubMed  PubMed Central  Google Scholar 

  • Lans C, Harper T, Georges K, Bridgewater E (2001) Medicinal and ethnoveterinary remedies of hunters in Trinidad. BMC Complement Altern Med 1:10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li CY, Devappa RK, Liu JX, Lv JM, Makkar HPS, Becker K (2010) Toxicity of Jatropha curcas phorbol esters in mice. Food Chem Toxicol 48(2):620–625

    Article  CAS  PubMed  Google Scholar 

  • Liberalino A, Bambirra E (1988) Jatropha curcas L. seeds: chemical analysis and toxicity. Arquivos Biol Technol 31(4):539–550

    CAS  Google Scholar 

  • Lillehau JR, Kleppe K, Siegel CW, Kupchan SM (1973) Reaction of biological thiols with tumor inhibitor Jatrophone – inhibition of RNA polymerase. Biochim Biophys Acta 327(1):92–100

    Article  PubMed  Google Scholar 

  • Lin J, Chen Y, Xu Y, Yan F, Tang L, Chen F (2003a) Cloning and expression of curcin, a ribosome-inactivating protein from the seeds of Jatropha curcas. Acta Bot Sin 45(7):858–863

    CAS  Google Scholar 

  • Lin J, Yan F, Tang L, Chen F (2003b) Antitumor effects of curcin from seeds of Jatropha curcas. Acta Pharmacol Sin 24(3):241–246

    CAS  PubMed  Google Scholar 

  • Liu SY, Sporer F, Wink M, Jourdane J, Henning R, Li YL, Ruppel A (1997) Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae), and phorbol esters in Jatropha curcas (Euphorbiaceae) with molluscicidal activity against the schistosome vector snails Oncomelania, Biomphalaria and Bulinus. Trop Med Int Health 2(2):179–188

    Article  CAS  PubMed  Google Scholar 

  • Makkar HPS, Becker K (1998) Jatropha curcas toxicity: identification of toxic principle(s). In: Garland T, Barr A (eds) Toxic plants and other natural toxicants. DBV Graz, Graz, pp 554–558

    Google Scholar 

  • Makkar HPS, Becker K, Sporer F, Wink M (1997) Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas. J Agric Food Chem 45(8):3152–3157

    Article  CAS  Google Scholar 

  • Makkar HPS, Aderibigbe AO, Becker K (1998) Comparative evaluation of non-toxic and toxic varieties of Jatropha curcas for chemical composition, digestibility, protein degradability and toxic factors. Food Chem 62(2):207–215

    Article  CAS  Google Scholar 

  • Mampane K, Joubert P, Hay I (1987) Jatropha curcas: use as a traditional Tswana medicine and its role as a cause of acute poisoning. Phytother Res 1(1):50–51

    Article  Google Scholar 

  • Marquez B, Neuville L, Moreau N, Genet J, dos Santos AF, de Andrade MCC et al (2005) Multidrug resistance reversal agent from Jatropha elliptica. Phytochemistry 66(15):1804–1811

    Article  CAS  PubMed  Google Scholar 

  • Martini LH, Souza CR, Marques PB, Calixto JB, Yunes RA, Souza DO (2000) Compounds extracted from Phyllantus and Jatropha elliptica inhibit the binding of [3 H]glutamate and [3 H]GMP-PNP in rat cerebral cortex membrane. Neurochem Res 25(2):211–215

    Article  CAS  PubMed  Google Scholar 

  • Matsuse IT, Lim YA, Hattori M, Correa M, Gupta MP (1999) A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes. J Ethnopharmacol 64(1):15–22

    Article  CAS  PubMed  Google Scholar 

  • Menezes FV, Carneiro EM, Delattre E, Boschero AC (1992) Inhibition of insulin release by Jatrophone. Braz J Med Biol Res 25(3):305–307

    CAS  PubMed  Google Scholar 

  • Mensah JK, Okoli RI, Ohaju-Obodo JO, Eifediyi K (2008) Phytochemical, nutritional and medical properties of some leafy vegetables consumed by Edo people of Nigeria. Afr J Biotechnol 7(14):2304–2309

    CAS  Google Scholar 

  • Mongkolvisut W, Sutthivaiyakit S, Leutbecher H, Mika S, Klaiber I, Möller W et al (2006) Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima. J Nat Prod 69(10):1435–1441

    Article  CAS  PubMed  Google Scholar 

  • Monteiro MVB, Bevilaqua CML, Morais SM, Machado LKA, Camurca-Vasconcelos ALF, Campello CC et al (2011) Anthelmintic activity of Jatropha curcas L. seeds on Haemonchus contortus. Vet Parasitol 182(2–4):259–263

    Article  PubMed  Google Scholar 

  • Muangman S, Thippornwong M, Tohtong R (2005) Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas. In Vivo 19:265–268

    CAS  PubMed  Google Scholar 

  • Mujumdar AM, Misar AV (2004) Anti-inflammatory activity of Jatropha curcas roots in mice and rats. J Ethnopharmacol 90(1):11–15

    Article  CAS  PubMed  Google Scholar 

  • Mujumdar AM, Upadhye AS, Misar AV (2000) Studies on antidiarrhoeal activity of Jatropha curcas root extract in albino mice. J Ethnopharmacol 70(2):183–187

    Article  CAS  PubMed  Google Scholar 

  • Naengchomnong W, Thebtaranonth Y, Wiriyachitra P, Okamoto KT, Clardy J (1986) Isolation and structure determination of four novel diterpenes from Jatropha curcas. Tetrahedron Lett 27(22):2439–2442

    Article  CAS  Google Scholar 

  • Nath LK, Dutta SK (1991) Extraction and purification of curcain, a protease from the latex of Jatropha curcas Linn. J Pharm Pharmacol 43(2):111–114

    Article  CAS  PubMed  Google Scholar 

  • Nithiyanantham S, Siddhuraju P, Francis G (2012) Potential of Jatropha curcas as a biofuel animal feed and health products. J Am Oil Chem Soc. doi:10.1007/s11746-012-2012-3

    Google Scholar 

  • Nwosu MO, Okafor JI (1995) Preliminary studies of the antifungal activities of some medicinal plants against Basidiobolus and some other pathogenic fungi. Mycoses 38(5–6):191–195

    Article  CAS  PubMed  Google Scholar 

  • Oduola T, Adeosun GO, Oduola TA, Avwioro GO, Oyeniyi MA (2005a) Mechanism of action of Jatropha gossypiifolia stem latex as a haemostatic agent. Eur J Gen Med 2(4):140–143

    Google Scholar 

  • Oduola T, Avwioro GO, Ayanniyi T (2005b) Suitability of the leaf extract of Jatropha gossypiifolia as an anticoagulant for biochemical and haematological analyses. Afr J Biotechnol 4(7):679–681

    Article  Google Scholar 

  • Oduola T, Popoola GB, Avwioro GO, Oduola TA, Ademousun AA, Lawal MO (2007) Use of Jatropha gossypiifolia stem latex as a haemostatic agent: how safe is it. J Med Plants Res 1(1):14–17

    Google Scholar 

  • Ojewole J (1983) Antibronchoconstrictor and antiarrhythmic effects of chemical compounds from Nigerian medicinal plants. Fitoterapia 54(4):153–161

    CAS  Google Scholar 

  • Ojewole JA, Odebiyi OO (1980) Neuromuscular and cardiovascular actions of tetramethylpyrazine from the stem of Jatropha podagrica. Planta Med 38(4):332–338

    Article  CAS  PubMed  Google Scholar 

  • Okuyama E, Okamoto Y, Yamazaki M, Satake M (1996) Pharmacologically active components of a Peruvian medicinal plant, huanarpo (Jatropha cilliata). Chem Pharm Bull 44(2):333–336

    Article  CAS  PubMed  Google Scholar 

  • Orhue E, Idu M, Ataman J (2008) Haematological and histopathological studies of Jatropha tanjorensis (JL Ellis and Soroja) leaves in rabbits. Asian J Biol Sci 1:84–89

    Article  Google Scholar 

  • Ornoregie ES, Osagie AU (2007) Phytochemical screening and anti-anaemic effect of Jatropha tanjorensis leaf in protein malnourished rats. Plant Arch 7(2):509–516

    Google Scholar 

  • Osoniyi O, Onajobi F (2003) Coagulant and anticoagulant activities in Jatropha curcas latex. J Ethnopharmacol 89(1):101–105

    Article  PubMed  Google Scholar 

  • Padhy S (2006) Review on ethnomedicines for diarrhoea diseases from Orissa: prevalence versus culture. J Hum Ecol 20(1):59–64

    Google Scholar 

  • Parthasarathy MR, Saradhi KP (1984) A coumarino-lignan from Jatropha glandulifera. Phytochemistry 23(4):867–869

    Article  CAS  Google Scholar 

  • Pertino M, Schmeda-Hirschmann G, Rodríguez JA, Theoduloz C (2007a) Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives. Planta Med 73(10):1095–1100

    Article  CAS  PubMed  Google Scholar 

  • Pertino M, Schmeda-Hirschmann G, Rodríguez JA, Theoduloz C (2007b) Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug “yagua rova” (Jatropha isabelli). J Ethnopharmacol 111(3):553–559

    Article  CAS  PubMed  Google Scholar 

  • Pertino M, Schmeda-Hirschmann G, Santos LS, Rodríguez JA, Theoduloz C (2007c) Biotransformation of jatrophone by Aspergillus niger ATCC 16404. Z Naturforsch B 62(2):275–279

    Article  CAS  Google Scholar 

  • Platt A, Horton M, Huang YS, Li Y, Anastasio AE, Mulyati NW et al (2010) The scale of population structure in Arabidopsis thaliana. PLoS Genet 6(2):e1000843

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pradhan S, Naik SN, Khan MA, Sahoo PK (2012) Experimental assessment of toxic phytochemicals in Jatropha curcas: oil, cake, bio-diesel and glycerol. J Sci Food Agric 92(3):511–519

    Article  CAS  PubMed  Google Scholar 

  • Prasad L, Pradhan S, Das LM, Naik SN (2012) Experimental assessment of toxic phorbol ester in oil, biodiesel and seed cake of Jatropha curcas and use of biodiesel in diesel engine. Appl Energy 93:245–250

    Article  CAS  Google Scholar 

  • Rahmani M, Ismail HM, Yin LT (1990) Jatrofolon A dan Jatrofatrion: Dua diterpena dari Jatropha gossypiifolia. Pertanika 13(3):405–408

    Google Scholar 

  • Rajasekaran P, Tishya S (2012) Antimicrobial activity of Jatropha glandulifera against some pathogenic microorganisms. Adv BioTech 11(9):40–42

    Google Scholar 

  • Ravindranath N, Venkataiah B, Ramesh C, Jayaprakash P, Das B (2003a) Jatrophenone, a novel macrocyclic bioactive diterpene from Jatropha gossypiifolia. Chem Pharm Bull 51(7):870–871

    Article  CAS  PubMed  Google Scholar 

  • Ravindranath N, Venkataiah B, Ramesh C, Jayaprakash P, Das B (2003b) Studies in phytochemicals. Part 40. Jatrophenone, a novel macrocyclic bioactive diterpene from Jatropha gossypiifolia. Chem Inform 34(49). doi:10.1002/chin.200349166

    Google Scholar 

  • Ravindranath N, Ravinder Reddy M, Ramesh C, Ramu R, Prabhakar A, Jagadeesh B et al (2004a) New lathyrane and podocarpane diterpenoids from Jatropha curcas. Chem Pharm Bull 52(5):608–611

    Article  CAS  PubMed  Google Scholar 

  • Ravindranath N, Ravinder Reddy M, Mahender G, Ramu R, Kumar KR, Das B (2004b) Deoxypreussomerins from Jatropha curcas: are they also plant metabolites? Phytochemistry 65(16):2387–2390

    Article  CAS  PubMed  Google Scholar 

  • Rensink WA, Buell CR (2004) Arabidopsis to rice. Applying knowledge from a weed to enhance our understanding of a crop species. Plant Physiol 135(2):622–629

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roach JS, Devappa RK, Makkar HPS, Becker K (2012) Isolation, stability and bioactivity of Jatropha curcas phorbol esters. Fitoterapia 83(3):586–592

    Article  CAS  PubMed  Google Scholar 

  • Rug M, Sporer F, Wink M, Liu S, Henning R (1997) Molluscicidal properties of J. curcas against vector snails of the human parasites Schistosoma mansoni and S. japonicum. In: Gubitz GM, Mittelbach M, Trab M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 227–232

    Google Scholar 

  • Sankara Subramanian S, Nagarajan S, Sulochana N (1971) Flavonoids of the leaves of Jatropha gossypiifolia. Phytochemistry 10(7):1690

    Article  Google Scholar 

  • Sant’Ana AEG, Lima R, Cavalcante S (1993) Fitoconstituintes químicos isolados de Jatropha elliptica. Atribuição dos deslocamentos químicos dos átomos de carbono e hidrogênio dos diterpenos Jatrofolonas A e B. Quim Nova 16(2):95–100, Portuguese

    Google Scholar 

  • Sato S, Hirakawa H, Isobe S, Fukai E, Watanabe A, Kato M et al (2011) Sequence analysis of the genome of an oil-bearing tree, Jatropha curcas L. DNA Res 18(1):65–76

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Scavone O, Panizza S, Cristodoulou M (1980) Plantas medicinais importadas sucedaneas que ocorrem no Brasil, de acordo com o seu uso medicinal. In: XXXI Congresso Nacional de Botanica. Sociedade Botanica do Brasil, Itabuna -Ilhéus, pp 18–19. Portuguese

    Google Scholar 

  • Schmeda-Hirschmann G (1993) Magic and medicinal plants of the Ayoreos of the Chaco Boreal (Paraguay). J Ethnopharmacol 39(2):105–111

    Article  CAS  PubMed  Google Scholar 

  • Schmeda-Hirschmann G, Tsichritzis F, Jakupovic J (1992) Diterpenes and a lignan from Jatropha grossidentata. Phytochemistry 31(5):1731–1735

    Article  CAS  Google Scholar 

  • Schmeda-Hirschmann G, Razmilic I, Sauvain M, Moretti C, Munoz V, Ruiz E et al (1996) Antiprotozoal activity of jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii. Phytother Res 10(5):375–378

    Article  CAS  Google Scholar 

  • Sherchan D, Thapa Y, Khadka R, Tiwari T (1989). Effect of green manure on rice production. PAC occasional paper, Pakhribas Agricultural Centre, 2:12

    Google Scholar 

  • Silva AM, Brum RL, Calixto JB (1995) The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors. Life Sci 57(9):863–871

    Article  CAS  PubMed  Google Scholar 

  • Silva G, Faroni L, Sousa A, Freitas R (2012) Bioactivity of Jatropha curcas L. to insect pests of stored products. J Stored Prod Res 48:111–113

    Article  Google Scholar 

  • Solsoloy AD (1995) Pesticidal efficacy of the formulated physic nut, Jatropha curcas L. oil on pests of selected field crops. Phil J Sci 124(1):59–74

    Google Scholar 

  • Staubmann R, Schubert-Zsilavecz M, Hiermann A (1997) The anti-inflammatory effect of J curcas leaves. In: Gubitz GM, Mittelbach M, Trabi M (eds) Biofuels and industrial products from Jatropha curcas. DBV Graz, Graz, pp 60–64

    Google Scholar 

  • Staubmann R, Schubert-Zsilavecz M, Hiermann A (1999) A complex of 5-hydroxypyrrolidin-2-one and pyrimidine-2, 4-dione isolated from Jatropha curcas. Phytochemistry 50(2):337–338

    Article  CAS  Google Scholar 

  • Subramanian SS, Nagarajan S, Sulochana N (1971) Flavonoids of some Euphorbiaceous plants. Phytochemistry 10(10):2548–2549

    Article  CAS  Google Scholar 

  • Sutthivaiyakit S, Mongkolvisut W, Ponsitipiboon P, Prabpai S, Kongsaeree P, Ruchirawat S et al (2003) A novel 8,9-seco-rhamnofolane and a new rhamnofolane endoperoxide from Jatropha integerrima roots. Tetrahedron Lett 44(18):3637–3640

    Article  CAS  Google Scholar 

  • Sutthivaiyakit S, Mongkolvisut W, Prabpai S, Kongsaeree P (2009) Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima. J Nat Prod 72(11):2024–2027

    Article  CAS  PubMed  Google Scholar 

  • Taylor MD, Smith AB III, Furst GT, Gunasekara SP, Bevelle CA, Cordell GA et al (1983) New anti-leukemic Jatrophone derivatives from Jatropha gossypiifolia – structural and stereochemical assignment through nuclear magnetic resonance spectroscopy. J Am Chem Soc 105(10):3177–3183

    Article  CAS  Google Scholar 

  • Thomas R, Sah NK, Sharma PB (2008) Therapeutic biology of Jatropha curcas: a mini review. Curr Pharm Biotechnol 9(4):315–324

    Article  CAS  PubMed  Google Scholar 

  • Tinto WF, John LMD, Reynolds WF, McLean S (1992) Triterpenoids of Jatropha gossypiifolia. J Nat Prod 55(6):807–809

    Article  CAS  Google Scholar 

  • Torrance SJ, Wiedhopf RM, Cole JR (1977) Antitumor agents from Jatropha macrorhiza (Euphorbiaceae). 3. acetylaleuritolic acid. J Pharm Sci 66(9):1348–1349

    Article  CAS  PubMed  Google Scholar 

  • van Andel T, Behari-Ramdas J, Havinga R, Groenendijk S (2008) The medicinal plant trade in Suriname. Ethnobot Res Appl 5:351–372

    Google Scholar 

  • van den Berg AJJ, Horsten SFAJ, Kettenes-van den Bosch JJ, Kroes BH, Labadie RP (1995) Multifidin – a cyanoglucoside in the latex of Jatropha multifida. Phytochemistry 40(2):597–598

    Article  Google Scholar 

  • Van der Sluis WG, Labadie RP (1989) Multifidol and multifidol glucoside from the latex of Jatropha multifida. Phytochemistry 28(9):2439–2441

    Article  Google Scholar 

  • Verma M, Pradhan S, Sharma S, Naik SN, Prasad R (2011) Efficacy of karanjin and phorbol ester fraction against termites (Odontotermes obesus). Int Biodeter Biodegrad 65(6):877–882

    Article  CAS  Google Scholar 

  • Viswanathan M, Ramesh N, Ahilan A, Lakshmanaperumalsamy P (2004) Phytochemical constituents and antimicrobial activity from the stems of Jatropha maheshwarii. Med Chem Res 13(6–7):361–368

    Article  CAS  Google Scholar 

  • Wang XC, Zheng ZP, Gan XW, Hu LH (2009) Jatrophalactam, a novel diterpenoid lactam isolated from Jatropha curcas. Org Lett 11(23):5522–5524

    Article  CAS  PubMed  Google Scholar 

  • Watson WH, Zabel V, Dominguez XA (1982) Riolozatrione. Acta Crystallogr B 38:689–691

    Article  Google Scholar 

  • Winkler E, Foidl N, Gübitz GM, Staubmann R, Steiner W (1997) Enzyme-supported oil extraction from Jatropha curcas seeds. Appl Biochem Biotechnol 63–65:449–456

    Article  PubMed  Google Scholar 

  • Zhang XP, Zhang ML, Su XH, Huo CH, Gu YC, Shi QW (2009) Chemical constituents of the plants from genus Jatropha. Chem Biodivers 6(12):2166–2183

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fundação Oswaldo Cruz (FIOCRUZ), Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Rio de Janeiro, RJ, Brazil

    Quézia de Sant’Anna, Julyana Rosa Machado, Raquel Pantoja Rodrigues, Marcela Oliveira Nogueira & Jochen Junker

Authors
  1. Quézia de Sant’Anna
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julyana Rosa Machado
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Raquel Pantoja Rodrigues
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marcela Oliveira Nogueira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jochen Junker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jochen Junker .

Editor information

Editors and Affiliations

  1. Department of Botany, University of Warangal, Warangal, India

    Bir Bahadur

  2. Crop Improvement Section, Principal Scientist, Directorate of Oilseeds Research, Hyderabad, 500 030, India

    Mulpuri Sujatha

  3. , Dept. of Functional Genomics and Biology, Fiocruz/IOC, Av.Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, Brazil

    Nicolas Carels

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

de Sant’Anna, Q., Machado, J.R., Rodrigues, R.P., Nogueira, M.O., Junker, J. (2013). Toward the Metabolomics of Jatropha curcas . In: Bahadur, B., Sujatha, M., Carels, N. (eds) Jatropha, Challenges for a New Energy Crop. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4915-7_31

Download citation

Publish with us

Policies and ethics

Search

Navigation