Abstract
As robot-assisted radical cystectomy (RARC) is emerging as a viable surgical technique for bladder cancer, it is imperative to evaluate oncologic outcomes as it compares to the gold standard of open radical cystectomy (ORC). For cancer-specific survival and recurrence-free survival, long-term data is lacking; however, medium-term data shows similar cancer-specific survival and overall survival with median follow-up as far out as 3 years. With regards to surrogates for oncologic efficacy, namely surgical margin status and lymph node yield, we present collective data from several large RARC series showing comparable rates of positive surgical margins and similar lymph node yields. We also examine several head to head comparisons of RARC compared to open radical cystectomy, which show similar oncologic outcomes. As long term data matures and more randomized controlled studies directly comparing RARC to ORC come to fruition, we will have more data potentially confirming that RARC provides equivalent oncologic outcomes to ORC.
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References
Dotan ZA, Kavanagh K, Yossepowitch O, Kaag M, Olgac S, Donat M, et al. Positive surgical margins in soft tissue following radical cystectomy for bladder cancer and cancer specific survival. J Urol. 2007;178(6):2308–12. discussion 13.
Pruthi RS, Nielsen ME, Nix J, Smith A, Schultz H, Wallen EM. Robotic radical cystectomy for bladder cancer: surgical and pathological outcomes in 100 consecutive cases. J Urol. 2010;183(2):510–4.
Mmeje CO, Nunez-Nateras R, Pruthi RS, Nielsen ME, Wallen EM, Humphreys MR, Castle EP. Robotic radical cystectomy: medium-term oncologic follow-up. J Clin Oncol. 2011;29 Suppl 7:abstr 288.
Novara G, Svatek RS, Karakiewicz PI, Skinner E, Ficarra V, Fradet Y, et al. Soft tissue surgical margin status is a powerful predictor of outcomes after radical cystectomy: a multicenter study of more than 4,400 patients. J Urol. 2010;183(6):2165–70.
Herr H, Lee C, Chang S, Lerner S. Standardization of radical cystectomy and pelvic lymph node dissection for bladder cancer: a collaborative group report. J Urol. 2004;171(5):1823–8. discussion 7–8.
Guru KA, Sternberg K, Wilding GE, Tan W, Butt ZM, Mohler JL, et al. The lymph node yield during robot-assisted radical cystectomy. BJU Int. 2008;102(2):231–4. discussion 4.
Kang SG, Kang SH, Lee YG, Rha KH, Jeong BC, Ko YH, et al. Robot-assisted radical cystectomy and pelvic lymph node dissection: a multi-institutional study from Korea. J Endourol. 2010;24(9):1435–40.
Hellenthal NJ, Hussain A, Andrews PE, Carpentier P, Castle E, Dasgupta P, et al. Surgical margin status after robot assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. J Urol. 2010;184(1):87–91.
Richards KA, Kader K, Pettus JA, Smith JJ, Hemal AK. Does initial learning curve compromise outcomes for robot-assisted radical cystectomy? A critical evaluation of the first 60 cases while establishing a robotics program. J Endourol. 2011;25(9):1553–8.
Leissner J, Ghoneim MA, Abol-Enein H, Thuroff JW, Franzaring L, Fisch M, et al. Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol. 2004;171(1):139–44.
Leissner J, Hohenfellner R, Thuroff JW, Wolf HK. Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int. 2000;85(7):817–23.
Herr HW, Bochner BH, Dalbagni G, Donat SM, Reuter VE, Bajorin DF. Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol. 2002;167(3):1295–8.
Poulsen AL, Horn T, Steven K. Radical cystectomy: extending the limits of pelvic lymph node dissection improves survival for patients with bladder cancer confined to the bladder wall. J Urol. 1998;160(6 Pt 1):2015–9. discussion 20.
Bochner BH, Herr HW, Reuter VE. Impact of separate versus en bloc pelvic lymph node dissection on the number of lymph nodes retrieved in cystectomy specimens. J Urol. 2001;166(6):2295–6.
Styn NR, Montgomery JS, Wood DP, Hafez KS, Lee CT, Tallman C, et al. Matched comparison of robotic-assisted and open radical cystectomy. Urology. 2012;79(6):1303–9.
Nix J, Smith A, Kurpad R, Nielsen ME, Wallen EM, Pruthi RS. Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer: perioperative and pathologic results. Eur Urol. 2010;57(2):196–201.
Parekh DJ, Messer J, FItzgerald J, Ercole B, Svatek R. Perioperative outcomes and oncologic efficacy from a pilot prospective randomized clinical trial of open versus robotic assisted radical cystectomy. J Urol. 2013;189(2):474–9.
Davis JW, Gaston K, Anderson R, Dinney CP, Grossman HB, Munsell MF, et al. Robot assisted extended pelvic lymphadenectomy at radical cystectomy: lymph node yield compared with second look open dissection. J Urol. 2011;185(1):79–83.
Pruthi RS, Smith A, Wallen EM. Evaluating the learning curve for robot-assisted laparoscopic radical cystectomy. J Endourol. 2008;22(11):2469–74.
Hayn MH, Hussain A, Mansour AM, Andrews PE, Carpentier P, Castle E, et al. The learning curve of robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. Eur Urol. 2010;58(2):197–202.
Ghoneim MA, Abdel-Latif M, el-Mekresh M, Abol-Enein H, Mosbah A, Ashamallah A, et al. Radical cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5 years later. J Urol. 2008;180(1):121–7.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, et al. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol. 2001;19(3):666–75.
Hayn MH, Hellenthal NJ, Seixas-Mikelus SA, Mansour AM, Stegemann A, Hussain A, et al. Is patient outcome compromised during the initial experience with robot-assisted radical cystectomy? Results of 164 consecutive cases. BJU Int. 2011;108(6):882–7.
Guillotreau J, Miocinovic R, Game X, Forest S, Malavaud B, Kaouk J, et al. Outcomes of laparoscopic and robotic radical cystectomy in the elderly patients. Urology. 2012;79(3):585–90.
Coward RM, Smith A, Raynor M, Nielsen M, Wallen EM, Pruthi RS. Feasibility and outcomes of robotic-assisted laparoscopic radical cystectomy for bladder cancer in older patients. Urology. 2011;77(5):1111–4.
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Parekh, D., Ransford, G.A., Kallingal, G.S. (2014). Oncologic Outcomes. In: Castle, E., Pruthi, R. (eds) Robotic Surgery of the Bladder. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4906-5_14
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DOI: https://doi.org/10.1007/978-1-4614-4906-5_14
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