Postnatal Coronary Morphogenesis and Growth

  • Robert J. Tomanek


The early postnatal stage of development is characterized by a rapid growth of the myocardium, which occurs by increases in both cardiomyocyte volume and number. This marked and rapid myocardial growth requires a rapid and substantial expansion of the coronary vasculature. In this regard, it has been documented that in the rat heart, approximately 50 % of the capillary bed present in the adult is formed during the first 3 or 4 weeks of life [1]. Many studies have addressed capillary growth using quantitative methods to assess various capillary parameters. These approaches are explained in the following section.


Left Ventricle Right Ventricle Capillary Density Postnatal Life Early Postnatal Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Endothelial cell


Fibroblast growth factor


Left ventricle


Length density (length/mm3)


Numerical density (number/mm2)


Right ventricle


Surface density (surface area/mm3)


Transforming growth factor β


Vascular endothelial factor


Volume density (volume/mm3)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Robert J. Tomanek
    • 1
  1. 1.Carver College of Medicine Cardiovascular CenterUniversity of IowaIowa CityUSA

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