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Microdialysis in Ocular Drug Development

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Microdialysis in Drug Development

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 4))

Abstract

Development of novel treatments for ocular diseases demands a complete understanding of ocular drug pharmacokinetics. Microdialysis is a continuous sampling technique that has been frequently applied for assessing ocular pharmacokinetic parameters. This sampling technique has gained considerable attention in ocular pharmacokinetics since it considerably reduces the requirement of large number of animals needed to obtain a complete pharmacokinetic profile. Remarkable progress has been made in ocular anterior and posterior segment microdialysis in recent years. These developments have simplified sampling of ocular fluids such as vitreous and aqueous humor. In this book chapter, the principle and application of microdialysis in measuring drug disposition in various segments of the eye will be discussed. This chapter will also highlight on recent progress on the development of various animal models and probe designs in ocular microdialysis.

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Acknowledgments

Research performed in Dr. Ashim K. Mitra’s laboratory was supported by National Institute of Health (NIH) Grants R01EY09171 and R01 EY 10659.

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Authors and Affiliations

  1. Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO, 64108, USA

    Mitesh R. Patel, Nanda K. Mandava & Ashim K. Mitra

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  1. Mitesh R. Patel
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  2. Nanda K. Mandava
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  3. Ashim K. Mitra
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Correspondence to Ashim K. Mitra .

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  1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Markus Müller

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Patel, M.R., Mandava, N.K., Mitra, A.K. (2013). Microdialysis in Ocular Drug Development. In: Müller, M. (eds) Microdialysis in Drug Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4815-0_11

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