Psychoneuromicrobiology: Cytomegalovirus Infection as a Putative Link Between Stress, Aging, and Immunity

  • Jos A. Bosch
  • Jerrald L. Rector
  • James E. Turner
  • Natalie E. Riddell
  • Briain o‘Hartaigh
  • Vikki E. Burns


Epidemiological evidence demonstrates increased morbidity and mortality in populations exposed to adverse psychosocial factors such as low socio-economic status and protracted psychological distress (Cohen and Herbert, Annu Rev Psychol 47:113–142, 1996; House et al., Science 241:540–545, 1988; Marmot, Lancet 365(9464):1099–1104, 2005; Schneiderman et al., Annu Rev Clin Psychol 1:607–628, 2005). While the data are clear, the precise mechanisms underlying these associations are yet to be determined (Antoni et al., Nat Rev Cancer 6(3):240–248, 2006; Cacioppo and Hawkley, Perspect Biol Med 46(3 Suppl):S39–52, 2003; Glaser and Kiecolt-Glaser, Nat Rev Immunol 5(3):243–251, 2005; McEwen, N Engl J Med 338(3):171–179, 1998; Uchino et al., Psychol Bull 119(3):488–531, 1996). We, and others, have argued that since increasing age is a major risk factor for a wide range of chronic diseases, the aging process itself may be an important target for such mechanistic research (Bosch et al., Brain Behav Immun 23(4):527–534, 2009; Nilsson, Med Hypotheses 47(1):39–42, 1996).


Cytomegalovirus CMV T cell immunity Stress Psychoneuroimmunology Psychosocial Aging 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jos A. Bosch
    • 1
    • 2
    • 3
  • Jerrald L. Rector
    • 2
  • James E. Turner
    • 4
  • Natalie E. Riddell
    • 5
  • Briain o‘Hartaigh
    • 2
  • Vikki E. Burns
    • 2
  1. 1.Department of Clinical PsychologyUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.School of Sport and Exercise SciencesUniversity of BirminghamBirminghamUK
  3. 3.Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH)University of HeidelbergMannheimGermany
  4. 4.CRUK Institute of Cancer StudiesUniversity of BirminghamBirminghamUK
  5. 5.School of Infection and ImmunityUniversity College LondonLondonUK

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