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Immunosenescence pp 221–239Cite as

The Role of Stress and Adrenal Hormones in Immunosenescence

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Abstract

Ageing is a continuous and slow process that compromises the normal functioning of various organs and systems in both qualitative and quantitative terms. During recent years, a growing body of studies has demonstrated that ageing remodels immune functions, a process known as immunosenescence. The clinical consequences of immunosenescence may include increased susceptibility to infectious diseases, neoplasias, metabolic diseases, osteoporosis and autoimmune diseases (Castle, Clin Infect Dis 31(2):578–585 2000; Pawelec et al., Crit Rev Oncol Hematol 75(2):165–172, 2010). This increased morbidity is not evenly distributed and seems to be influenced by other immune-modulating factors, including genetic background and chronic stress exposure (Bauer, Stress 8(1):69–83, 2005). Indeed, psychological stress appears to be an important factor leading to earlier onset of many age-related diseases (McEwen, New Engl J Med 338:171–179, 1998). Therefore, a better understanding of how stress is likely to promote ‘biological ageing’ may lead to clinical interventions or policies with a broad public health impact.

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Acknowledgements

This study was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Brazil).

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Authors and Affiliations

  1. Institute of Biomedical Research and Faculty of Biosciences, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga 6690, 2º andar., P.O. Box 1429, 90.610-000, Porto Alegre, RS, Brazil

    Moisés Evandro Bauer

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  1. Moisés Evandro Bauer
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Correspondence to Moisés Evandro Bauer .

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Editors and Affiliations

  1. University of Amsterdam, Oudezijds Achterburgwal 237, Amsterdam, 1012 DL, Netherlands

    Jos A. Bosch

  2. University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom

    Anna C. Phillips

  3. University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom

    Janet M. Lord

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Bauer, M.E. (2013). The Role of Stress and Adrenal Hormones in Immunosenescence. In: Bosch, J., Phillips, A., Lord, J. (eds) Immunosenescence. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4776-4_13

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