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Sodium Fluxes and Astroglial Function

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Book cover Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 961))

Abstract

Astrocytes exhibit their excitability based on variations in cytosolic Ca2+ levels, which leads to variety of signalling events. Only recently, however, intracellular fluctuations of more abundant cation Na+ are brought in the limelight of glial signalling. Indeed, astrocytes possess several plasmalemmal molecular entities that allow rapid transport of Na+ across the plasma membrane: (1) ionotropic receptors, (2) canonical transient receptor potential cation channels, (3) neurotransmitter transporters and (4) sodium-calcium exchanger. Concerted action of these molecules in controlling cytosolic Na+ may complement Ca2+ signalling to provide basis for complex bidirectional astrocyte-neurone communication at the tripartite synapse.

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Authors and Affiliations

  1. Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK

    Alexei Verkhratsky

  2. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

    Alexei Verkhratsky & Vladimir Parpura

  3. Department of Neurosciences, University of the Basque Country UPV/EHU, Leioa, Spain

    Alexei Verkhratsky & Vladimir Parpura

  4. Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

    Mami Noda

  5. Department of Neurobiology, Center for Glial Biology in Medicine, Civitan International Research Center, Atomic Force Microscopy & Nanotechnology Laboratories, and Evelyn F. McKnight Brain Institute, University of Alabama, Birmingham, USA

    Vladimir Parpura

  6. Department of Biotechnology, University of Rijeka, Rijeka, Croatia

    Vladimir Parpura

  7. Institute of Physiology and Pathophysiology, Universal Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany

    Sergei Kirischuk

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  2. Mami Noda
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  3. Vladimir Parpura
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  4. Sergei Kirischuk
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Corresponding author

Correspondence to Alexei Verkhratsky .

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  1. Dipto. Neuroscienze e di, Università di Napoli Fac. Medicina e Chirurgia, Napoli, Italy

    Lucio Annunziato

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Verkhratsky, A., Noda, M., Parpura, V., Kirischuk, S. (2013). Sodium Fluxes and Astroglial Function. In: Annunziato, L. (eds) Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications. Advances in Experimental Medicine and Biology, vol 961. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4756-6_25

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