Transcriptional Regulation of ncx1 Gene in the Brain

  • Valeria Valsecchi
  • Giuseppe Pignataro
  • Rossana Sirabella
  • Carmela Matrone
  • Francesca Boscia
  • Antonella Scorziello
  • Maria Josè Sisalli
  • Elga Esposito
  • Nicola Zambrano
  • Mauro Cataldi
  • Gianfranco Di Renzo
  • Lucio AnnunziatoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 961)


The ubiquitous sodium–calcium exchanger isoform 1 (NCX1) is a ­bidirectional transporter that plays a relevant role under physiological and pathophysiological conditions including brain ischemia by regulating intraneuronal Ca2+ and Na+ homeostasis. Although changes in ncx1 protein and transcript expression have been detected during stroke, its transcriptional regulation is still largely unexplored. Here, we reviewed our recent findings on several transcription factors including cAMP response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and hypoxia-inducible factor-1 (HIF-1) in the control of the ncx1 gene expression in neuronal cells.


ncx1 HIF-1 Ischemic preconditioning Hypoxia Transcriptional regulation 



This work was supported by COFIN2008, Ricerca-Sanitaria RF-FSL352059 Ricerca finalizzata 2006, Ricerca-Oncologica 2006, Progetto-Strategico 2007, Progetto Ordinario 2007, Ricerca finalizzata 2009, Ricerca-Sanitaria Progetto Ordinario by Ministero della Salute 2008, and MIUR, Progetto Operativo Nazionale (PON) 01602 all to LA.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Valeria Valsecchi
    • 1
  • Giuseppe Pignataro
    • 1
  • Rossana Sirabella
    • 2
  • Carmela Matrone
    • 1
  • Francesca Boscia
    • 1
  • Antonella Scorziello
    • 1
  • Maria Josè Sisalli
    • 1
  • Elga Esposito
    • 1
  • Nicola Zambrano
    • 3
  • Mauro Cataldi
    • 1
  • Gianfranco Di Renzo
    • 1
  • Lucio Annunziato
    • 1
    Email author
  1. 1.Division of Pharmacology, Department of Neuroscience, School of Medicine“Federico II” University of NaplesNaplesItaly
  2. 2.Fondazione IRCCS SDNNaplesItaly
  3. 3.Department of Biochemistry and Medical Biotechnology“Federico II” University of NaplesNaplesItaly

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