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Adoptive T Cell Transfer

  • Donald R. Shaffer
  • Conrad Russell Y. Cruz
  • Cliona M. Rooney
Chapter

Abstract

The clinical use of adoptively-transferred T or NK lymphocytes with anti-tumor activity is gaining in popularity as reports of success accumulate. High specific activity with minimal off target effects contribute to a class of therapy with minimal toxicity that is transformative for cancer patients, who with their physicians have come to accept severe short and long term toxicities as the cost of a frequently small hope of cure or extension of life. However, the successes of cell therapies are as yet in the minority and scientists are developing and testing strategies to improve the function and persistence of adoptively transferred lymphocytes in the face of multiple, potent immune evasion strategies used by tumors and their accessory cells to coexist with an intact immune response. These strategies include combination with chemotherapies and/or radiation and genetic modifications that improve T cell function and tumor targeting. However many of these strategies come with a price and re-introduce toxicities including death in rare cases. This chapter will outline the development of tumor-specific lymphocyte therapies, highlighting successes and difficulties and discussing potential ways forward in this exciting field.

Keywords

Natural Killer Cell Human Leukocyte Antigen Nasopharyngeal Carcinoma Graft Versus Host Disease Chimeric Antigen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Donald R. Shaffer
    • 1
  • Conrad Russell Y. Cruz
    • 1
  • Cliona M. Rooney
    • 1
  1. 1.Department of Pediatrics-Hematology and OncologyBaylor College of MedicineHoustonUSA

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