Antibodies as Cancer Immunotherapy

  • Devalingam Mahalingam
  • Tyler J. Curiel


Infused antibodies are the most successful immune-based agents to treat certain cancers. However, their modes of action are not always dependent on immune mechanisms aside from antigen-specific targeting. Immune mechanisms include direct and indirect cytotoxicity while nonimmune mechanisms include the targeting of toxins, such as drugs or irradiation sources, directly to the tumor, the subject of  Chap. 12. Therapeutic antibodies can be chimeric or humanized (part human and part animal, usually mouse), but fully human antibodies are in trials or have been FDA approved. This chapter will summarize the current FDA-approved antibodies to treat cancer, and highlight promising antibodies in development.


Epidermal Growth Factor Receptor Human Epidermal Growth Factor Receptor Chronic Lymphocytic Leukemia Metastatic Colorectal Cancer KRAS Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Thanks to our colleagues for many informative discussions. This work was supported by CA105207, CA054174, FD003118, the Fanny Rippel Foundation, the Voelcker Trust, the Hayes Endowment, The Holly Beach Public Library Association, The Owens Foundation, The Hogg Foundation and UTHSCSA endowments.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Cancer Therapy & Research CenterUniversity of Texas Health Science Center, Adult Cancer Program, STRF MC8252San AntonioUSA

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